Factors influencing the measurement of lysosomal enzymes activity in human cerebrospinal fluid

Measurements of the activities of lysosomal enzymes in cerebrospinal fluid have recently been proposed as putative biomarkers for Parkinson's disease and other synucleinopathies. To define the operating procedures useful for ensuring the reliability of these measurements, we analyzed several pr...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101453-e101453
Hauptverfasser:	Persichetti, Emanuele, Chiasserini, Davide, Parnetti, Lucilla, Eusebi, Paolo, Paciotti, Silvia, De Carlo, Claudia, Codini, Michela, Tambasco, Nicola, Rossi, Aroldo, El-Agnaf, Omar M A, El Agnaf, Omar M, Calabresi, Paolo, Beccari, Tommaso
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha-L-Fucosidase - cerebrospinal fluid alpha-Mannosidase - cerebrospinal fluid Alzheimer's disease Analysis beta-Galactosidase - cerebrospinal fluid beta-N-Acetylhexosaminidases - cerebrospinal fluid Biochemistry Biology and Life Sciences Biomarkers Biomarkers - cerebrospinal fluid Cathepsin D Cathepsin D - cerebrospinal fluid Cathepsin E Cathepsin E - cerebrospinal fluid Cathepsins Cerebrospinal fluid Dementia Enzymes Female Freeze thaw cycles Freeze-thawing Galactosidase Glucosylceramidase Glucosylceramidase - cerebrospinal fluid Glucuronidase - cerebrospinal fluid Humans Hydrolases - cerebrospinal fluid Laboratories Lysosomal enzymes Lysosomes - enzymology Male Mannosidase Mannosidases - cerebrospinal fluid Mathematical analysis Measurement Medical diagnosis Medicine Medicine and health sciences Middle Aged Movement disorders Mutation Neurodegenerative diseases Neurological disorders Neurology Parkinson Disease - diagnosis Parkinson Disease - enzymology Parkinson's disease Pharmaceutical sciences Reliability analysis Reliability aspects Reproducibility of Results Storage conditions β-Galactosidase
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