Cryptorchidism and infertility in rats with targeted disruption of the Adamts16 locus

A Disintegrin And Metalloproteinase with ThromboSpondin motifs16 (ADAMTS-16) is a member of a family of metalloproteinases. Using a novel zinc-finger nuclease based gene-edited rat model harboring a targeted mutation of the Adamts16 locus, we previously reported this gene to be linked to blood press...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e100967-e100967
Hauptverfasser:	Abdul-Majeed, Shakila, Mell, Blair, Nauli, Surya M, Joe, Bina
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities ADAM protein ADAM Proteins - genetics Alcohol Animals Antigens Biology and Life Sciences Blood pressure Cryptorchidism Cryptorchidism - enzymology Cryptorchidism - genetics Cryptorchidism - pathology Ethanol Extracellular matrix Gene expression Genetic Loci Genetic modification Genitourinary system Genomics Germ cells Hypertension Infertility Infertility, Male - enzymology Infertility, Male - genetics Infertility, Male - pathology Kidney - abnormalities Life sciences Loci Male Male sterility Males Medicine and Health Sciences Mutation Nuclease Pharmacology Physiology Precision medicine Proteins Rats Rodents Spermatogenesis Sterility Testes Thrombospondin Tubules Undescended testes Urogenital system Vacuoles Zinc Zinc finger proteins
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