Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms
Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affect...
Gespeichert in:
| Veröffentlicht in: | PloS one 2014-06, Vol.9 (6), p.e101372-e101372 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e101372 |
|---|---|
| container_issue | 6 |
| container_start_page | e101372 |
| container_title | PloS one |
| container_volume | 9 |
| creator | Bodnar, Michael Hovington, Cindy L Buchy, Lisa Malla, Ashok K Joober, Ridha Lepage, Martin |
| description | Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affective first-episode of psychosis (FEP) patients to advance our understanding of the pathophysiology of primary negative symptoms.
This study included 62 non-affective FEP patients and 60 non-clinical controls; 16 patients were identified with PNS (i.e., at least 1 primary negative symptom at moderate or greater severity sustained for at least 6 consecutive months). Using cortical thickness analyses, we explored for differences between PNS and non-PNS patients as well as between each patient group and healthy controls; cut-off threshold was set at p |
| doi_str_mv | 10.1371/journal.pone.0101372 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1541796406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A417148726</galeid><doaj_id>oai_doaj_org_article_ff65949704b845ff9d47ad3999a0ef0d</doaj_id><sourcerecordid>A417148726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-897c7ba90afa344e28ea0f8762cd40611bfeed448925ac9d849f6b609e3f974b3</originalsourceid><addsrcrecordid>eNptUstu1DAUjRCIPuAPEFhiUxYZ7Nh5eFOpGhUoqgSLsrYc53rGo8QOtqdovoGfxplJqw6qvLB1fM65D50se0fwgtCafN64rbeyX4zOwgITnMDiRXZKOC3yqsD05ZP3SXYWwgbjkjZV9To7KRivednQ0-zv0vlolOxRXBtrjV0hY1GEYXTe5aP0BmL63GytisZZdHH38_uniWKdzaXWkOB7QNr4EHMYTXAdIKfRGHZq7YIJaJTRgI0B_TFxjUbwCYwJQBZWci8Ou2GMbghvslda9gHezvd59uvL9d3yW3774-vN8uo2VyWnMW94repWciy1pIxB0YDEuqmrQnUMV4S0GqBjrOFFKRXvGsZ11VaYA9W8Zi09zz4cfMfeBTHvMQhSMlLzKlkkxs2B0Tm5EaM3g_Q74aQRe8D5lZDT2noQWlclT-vErG1YqTXvWC07yjmXGDTuktflXG3bDtCpNLqX_ZHp8Y81a7Fy94LhuqKUJIOL2cC731sIUQwmKOh7acFt930XFFOMcaJ-_I_6_HQzayXTAMZql-qqyVRcJRJhTV1MrMUzrHQ6GIxKodMm4UcCdhAo70LwoB9nJFhMkX1oRkyRFXNkk-z90_08ih4ySv8BLdzr_g</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1541796406</pqid></control><display><type>article</type><title>Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Bodnar, Michael ; Hovington, Cindy L ; Buchy, Lisa ; Malla, Ashok K ; Joober, Ridha ; Lepage, Martin</creator><creatorcontrib>Bodnar, Michael ; Hovington, Cindy L ; Buchy, Lisa ; Malla, Ashok K ; Joober, Ridha ; Lepage, Martin</creatorcontrib><description>Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affective first-episode of psychosis (FEP) patients to advance our understanding of the pathophysiology of primary negative symptoms.
This study included 62 non-affective FEP patients and 60 non-clinical controls; 16 patients were identified with PNS (i.e., at least 1 primary negative symptom at moderate or greater severity sustained for at least 6 consecutive months). Using cortical thickness analyses, we explored for differences between PNS and non-PNS patients as well as between each patient group and healthy controls; cut-off threshold was set at p<0.01, corrected for multiple comparisons.
A thinner cortex prominently in the right superior temporal gyrus extending into the temporo-parietal junction (TPJ), right parahippocampal gyrus, and left orbital frontal gyrus was identified in PNS patients vs. non-PNS patients. Compared with healthy controls, PNS patients showed a thinner cortex prominently in the right superior temporal gyrus, right parahippocampal gyrus, and right cingulate; non-PNS patients showed a thinner cortex prominently in the parahippocampal gyrus bi-laterally.
Cortical thinning in the early stages of non-affective psychosis is present in the frontal and temporo-parietal regions in patients with PNS. With these brain regions strongly related to social cognitive functioning, our finding suggests a potential link between primary negative symptoms and social cognitive deficits through common brain etiologies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0101372</identifier><identifier>PMID: 24979583</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Antipsychotics ; Biology and Life Sciences ; Brain ; Cognitive ability ; Cortex ; Cortex (cingulate) ; Cortex (frontal) ; Cortex (parietal) ; Cortex (temporal) ; Development and progression ; Early intervention ; Emotional behavior ; Etiology ; Female ; Frontal gyrus ; Health aspects ; Humans ; Illnesses ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medicine and Health Sciences ; Mental disorders ; Mental health ; Morphometry ; Neurology ; Neurosurgery ; Parahippocampal gyrus ; Parietal Lobe - pathology ; Parietal Lobe - physiopathology ; Patients ; Prevention ; Psychiatry ; Psychosis ; Psychotic Disorders - diagnosis ; Psychotic Disorders - pathology ; Psychotropic drugs ; Schizophrenia ; Studies ; Superior temporal gyrus ; Temporal gyrus ; Temporal lobe ; Temporal Lobe - pathology ; Temporal Lobe - physiopathology ; Thinning</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e101372-e101372</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Bodnar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Bodnar et al 2014 Bodnar et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-897c7ba90afa344e28ea0f8762cd40611bfeed448925ac9d849f6b609e3f974b3</citedby><cites>FETCH-LOGICAL-c593t-897c7ba90afa344e28ea0f8762cd40611bfeed448925ac9d849f6b609e3f974b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076331/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076331/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24979583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bodnar, Michael</creatorcontrib><creatorcontrib>Hovington, Cindy L</creatorcontrib><creatorcontrib>Buchy, Lisa</creatorcontrib><creatorcontrib>Malla, Ashok K</creatorcontrib><creatorcontrib>Joober, Ridha</creatorcontrib><creatorcontrib>Lepage, Martin</creatorcontrib><title>Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affective first-episode of psychosis (FEP) patients to advance our understanding of the pathophysiology of primary negative symptoms.
This study included 62 non-affective FEP patients and 60 non-clinical controls; 16 patients were identified with PNS (i.e., at least 1 primary negative symptom at moderate or greater severity sustained for at least 6 consecutive months). Using cortical thickness analyses, we explored for differences between PNS and non-PNS patients as well as between each patient group and healthy controls; cut-off threshold was set at p<0.01, corrected for multiple comparisons.
A thinner cortex prominently in the right superior temporal gyrus extending into the temporo-parietal junction (TPJ), right parahippocampal gyrus, and left orbital frontal gyrus was identified in PNS patients vs. non-PNS patients. Compared with healthy controls, PNS patients showed a thinner cortex prominently in the right superior temporal gyrus, right parahippocampal gyrus, and right cingulate; non-PNS patients showed a thinner cortex prominently in the parahippocampal gyrus bi-laterally.
Cortical thinning in the early stages of non-affective psychosis is present in the frontal and temporo-parietal regions in patients with PNS. With these brain regions strongly related to social cognitive functioning, our finding suggests a potential link between primary negative symptoms and social cognitive deficits through common brain etiologies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antipsychotics</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Cognitive ability</subject><subject>Cortex</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Cortex (parietal)</subject><subject>Cortex (temporal)</subject><subject>Development and progression</subject><subject>Early intervention</subject><subject>Emotional behavior</subject><subject>Etiology</subject><subject>Female</subject><subject>Frontal gyrus</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Morphometry</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Parahippocampal gyrus</subject><subject>Parietal Lobe - pathology</subject><subject>Parietal Lobe - physiopathology</subject><subject>Patients</subject><subject>Prevention</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - pathology</subject><subject>Psychotropic drugs</subject><subject>Schizophrenia</subject><subject>Studies</subject><subject>Superior temporal gyrus</subject><subject>Temporal gyrus</subject><subject>Temporal lobe</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - physiopathology</subject><subject>Thinning</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUstu1DAUjRCIPuAPEFhiUxYZ7Nh5eFOpGhUoqgSLsrYc53rGo8QOtqdovoGfxplJqw6qvLB1fM65D50se0fwgtCafN64rbeyX4zOwgITnMDiRXZKOC3yqsD05ZP3SXYWwgbjkjZV9To7KRivednQ0-zv0vlolOxRXBtrjV0hY1GEYXTe5aP0BmL63GytisZZdHH38_uniWKdzaXWkOB7QNr4EHMYTXAdIKfRGHZq7YIJaJTRgI0B_TFxjUbwCYwJQBZWci8Ou2GMbghvslda9gHezvd59uvL9d3yW3774-vN8uo2VyWnMW94repWciy1pIxB0YDEuqmrQnUMV4S0GqBjrOFFKRXvGsZ11VaYA9W8Zi09zz4cfMfeBTHvMQhSMlLzKlkkxs2B0Tm5EaM3g_Q74aQRe8D5lZDT2noQWlclT-vErG1YqTXvWC07yjmXGDTuktflXG3bDtCpNLqX_ZHp8Y81a7Fy94LhuqKUJIOL2cC731sIUQwmKOh7acFt930XFFOMcaJ-_I_6_HQzayXTAMZql-qqyVRcJRJhTV1MrMUzrHQ6GIxKodMm4UcCdhAo70LwoB9nJFhMkX1oRkyRFXNkk-z90_08ih4ySv8BLdzr_g</recordid><startdate>20140630</startdate><enddate>20140630</enddate><creator>Bodnar, Michael</creator><creator>Hovington, Cindy L</creator><creator>Buchy, Lisa</creator><creator>Malla, Ashok K</creator><creator>Joober, Ridha</creator><creator>Lepage, Martin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140630</creationdate><title>Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms</title><author>Bodnar, Michael ; Hovington, Cindy L ; Buchy, Lisa ; Malla, Ashok K ; Joober, Ridha ; Lepage, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-897c7ba90afa344e28ea0f8762cd40611bfeed448925ac9d849f6b609e3f974b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antipsychotics</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Cognitive ability</topic><topic>Cortex</topic><topic>Cortex (cingulate)</topic><topic>Cortex (frontal)</topic><topic>Cortex (parietal)</topic><topic>Cortex (temporal)</topic><topic>Development and progression</topic><topic>Early intervention</topic><topic>Emotional behavior</topic><topic>Etiology</topic><topic>Female</topic><topic>Frontal gyrus</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Morphometry</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Parahippocampal gyrus</topic><topic>Parietal Lobe - pathology</topic><topic>Parietal Lobe - physiopathology</topic><topic>Patients</topic><topic>Prevention</topic><topic>Psychiatry</topic><topic>Psychosis</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - pathology</topic><topic>Psychotropic drugs</topic><topic>Schizophrenia</topic><topic>Studies</topic><topic>Superior temporal gyrus</topic><topic>Temporal gyrus</topic><topic>Temporal lobe</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - physiopathology</topic><topic>Thinning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bodnar, Michael</creatorcontrib><creatorcontrib>Hovington, Cindy L</creatorcontrib><creatorcontrib>Buchy, Lisa</creatorcontrib><creatorcontrib>Malla, Ashok K</creatorcontrib><creatorcontrib>Joober, Ridha</creatorcontrib><creatorcontrib>Lepage, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bodnar, Michael</au><au>Hovington, Cindy L</au><au>Buchy, Lisa</au><au>Malla, Ashok K</au><au>Joober, Ridha</au><au>Lepage, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-06-30</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e101372</spage><epage>e101372</epage><pages>e101372-e101372</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affective first-episode of psychosis (FEP) patients to advance our understanding of the pathophysiology of primary negative symptoms.
This study included 62 non-affective FEP patients and 60 non-clinical controls; 16 patients were identified with PNS (i.e., at least 1 primary negative symptom at moderate or greater severity sustained for at least 6 consecutive months). Using cortical thickness analyses, we explored for differences between PNS and non-PNS patients as well as between each patient group and healthy controls; cut-off threshold was set at p<0.01, corrected for multiple comparisons.
A thinner cortex prominently in the right superior temporal gyrus extending into the temporo-parietal junction (TPJ), right parahippocampal gyrus, and left orbital frontal gyrus was identified in PNS patients vs. non-PNS patients. Compared with healthy controls, PNS patients showed a thinner cortex prominently in the right superior temporal gyrus, right parahippocampal gyrus, and right cingulate; non-PNS patients showed a thinner cortex prominently in the parahippocampal gyrus bi-laterally.
Cortical thinning in the early stages of non-affective psychosis is present in the frontal and temporo-parietal regions in patients with PNS. With these brain regions strongly related to social cognitive functioning, our finding suggests a potential link between primary negative symptoms and social cognitive deficits through common brain etiologies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24979583</pmid><doi>10.1371/journal.pone.0101372</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-06, Vol.9 (6), p.e101372-e101372 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1541796406 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Antipsychotics Biology and Life Sciences Brain Cognitive ability Cortex Cortex (cingulate) Cortex (frontal) Cortex (parietal) Cortex (temporal) Development and progression Early intervention Emotional behavior Etiology Female Frontal gyrus Health aspects Humans Illnesses Magnetic Resonance Imaging Male Medical imaging Medicine and Health Sciences Mental disorders Mental health Morphometry Neurology Neurosurgery Parahippocampal gyrus Parietal Lobe - pathology Parietal Lobe - physiopathology Patients Prevention Psychiatry Psychosis Psychotic Disorders - diagnosis Psychotic Disorders - pathology Psychotropic drugs Schizophrenia Studies Superior temporal gyrus Temporal gyrus Temporal lobe Temporal Lobe - pathology Temporal Lobe - physiopathology Thinning |
| title | Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T10%3A30%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cortical%20thinning%20in%20temporo-parietal%20junction%20(TPJ)%20in%20non-affective%20first-episode%20of%20psychosis%20patients%20with%20persistent%20negative%20symptoms&rft.jtitle=PloS%20one&rft.au=Bodnar,%20Michael&rft.date=2014-06-30&rft.volume=9&rft.issue=6&rft.spage=e101372&rft.epage=e101372&rft.pages=e101372-e101372&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0101372&rft_dat=%3Cgale_plos_%3EA417148726%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1541796406&rft_id=info:pmid/24979583&rft_galeid=A417148726&rft_doaj_id=oai_doaj_org_article_ff65949704b845ff9d47ad3999a0ef0d&rfr_iscdi=true |