Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma

Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is important for local tumour control, however, radioresistance remains a substant...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e100738
Hauptverfasser:	Lynam-Lennon, Niamh, Maher, Stephen G, Maguire, Aoife, Phelan, James, Muldoon, Cian, Reynolds, John V, O'Sullivan, Jacintha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Aged Alterations Analysis Bioenergetics Biology and Life Sciences Cancer therapies Cell cycle Cell Line, Tumor Chemoradiotherapy Chemoradiotherapy, Adjuvant Deoxyribonucleic acid DNA Electron transport Energy Energy metabolism Energy Metabolism - drug effects Energy Metabolism - radiation effects Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagus Female Gene amplification Gene expression Genetic aspects Genomes Glucose metabolism Glycolysis Humans Kinases Male Medical prognosis Medicine and Health Sciences Metabolism Middle Aged Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - radiation effects Mitochondrial DNA Mitochondrial Size - drug effects Mitochondrial Size - radiation effects Mutagenesis - drug effects Mutagenesis - radiation effects Mutation Oxidative metabolism Oxidative phosphorylation Oxidative stress Pathology Phosphorylation Pretreatment Radiation Radiation therapy Radiation Tolerance - drug effects Radioresistance Surgery Treatment Outcome Tumors
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