Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2

AKT plays an important role in the control of cell proliferation and survival. Aberrant activation of AKT frequently occurs in human cancers making it an attractive drug targets and leading to the synthesis of numerous AKT inhibitors as therapeutic candidates. Less is known regarding proteins that c...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e101070-e101070
Hauptverfasser:	Hsieh, Tze-chen, Lin, Chia-Yi, Bennett, Dylan John, Wu, Erxi, Wu, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Affinity Affinity chromatography AKT protein AKT1 protein Apoptosis Asparagine Binding Biochemistry Biology and Life Sciences Cancer Carrier Proteins - metabolism Cell Line Cell proliferation Cell survival Chemical properties Chromatography Clonal deletion Enzyme Activation Enzymes Gene Expression Gene Knockdown Techniques Health aspects Histidine Homology Humans Hydrogen Bonding Inhibition Kinases Modelling Models, Molecular Molecular biology Molecular modelling mRNA Phosphorylation Pleckstrin Prostate Protein Binding Protein Conformation Protein Stability Protein Transport Proteins Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Quinone Quinone Reductases - chemistry Quinone Reductases - genetics Quinone Reductases - metabolism Quinones Reductase Resveratrol RNA RNA Stability Stilbenes - chemistry Stilbenes - metabolism Tumors
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