Dengue type four viruses with E-Glu345Lys adaptive mutation from MRC-5 cells induce low viremia but elicit potent neutralizing antibodies in rhesus monkeys

Knowledge of virulence and immunogenicity is important for development of live-attenuated dengue vaccines. We previously reported that an infectious clone-derived dengue type 4 virus (DENV-4) passaged in MRC-5 cells acquired a Glu345Lys (E-E345K) substitution in the E protein domain III (E-DIII). Th...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e100130
Hauptverfasser:	Lin, Hsiao-Han, Lee, Hsiang-Chi, Li, Xiao-Feng, Tsai, Meng-Ju, Hsiao, Hung-Ju, Peng, Jia-Guan, Sue, Shih-Che, Qin, Cheng-Feng, Wu, Suh-Chin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Anticoagulants Biology and Life Sciences Cell Line Cercopithecus aethiops Dengue Dengue - immunology Dengue - mortality Dengue - virology Dengue fever Dengue virus Dengue Virus - genetics Dengue Virus - immunology Disease Models, Animal DNA Mutational Analysis E protein Heparin Heparin - metabolism Heparin - pharmacology Immunization Immunogenicity Infectious diseases Infectivity Macaca mulatta Mice Monkeys Mutants Mutation Neutralizing Protein Binding Proteins Site-directed mutagenesis Vaccine development Vaccines Vector-borne diseases Vero Cells Viral diseases Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Viremia Virulence Virus Replication - drug effects Viruses
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