Left ventricular myocardial function in hemodialysis and nondialysis uremia patients: a three-dimensional speckle-tracking echocardiography study
Several studies have demonstrated that uremic patients who have preserved left ventricular ejection fraction (LVEF) could still have the potential for systolic dysfunction. The aim of this study was to assess the differences between the left ventricular (LV) myocardial function in hemodialysis and n...
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| description | Several studies have demonstrated that uremic patients who have preserved left ventricular ejection fraction (LVEF) could still have the potential for systolic dysfunction. The aim of this study was to assess the differences between the left ventricular (LV) myocardial function in hemodialysis and nondialysis uremic patients based on three-dimensional speckle-tracking echocardiography.
The study population consisted of 35 maintenance hemodialysis patients (the hemodialysis group), 30 uremic patients who were hospitalized for the creation of a primary arteriovenous fistula (the nondialysis group), and 32 healthy volunteers. All of the patients had normal left ventricular ejection fractions (i.e., 55% or greater). Three-dimensional speckle tracking echocardiography was performed to assess the left ventricle's global three-dimensional strain, regional longitudinal strain, circumferential strain, and radial strain.
The left ventricular regional longitudinal strain, radial strain, circumferential strain, and global three-dimensional strain were significantly decreased in the nondialysis patients compared with the other two groups (all, P |
| doi_str_mv | 10.1371/journal.pone.0100265 |
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The study population consisted of 35 maintenance hemodialysis patients (the hemodialysis group), 30 uremic patients who were hospitalized for the creation of a primary arteriovenous fistula (the nondialysis group), and 32 healthy volunteers. All of the patients had normal left ventricular ejection fractions (i.e., 55% or greater). Three-dimensional speckle tracking echocardiography was performed to assess the left ventricle's global three-dimensional strain, regional longitudinal strain, circumferential strain, and radial strain.
The left ventricular regional longitudinal strain, radial strain, circumferential strain, and global three-dimensional strain were significantly decreased in the nondialysis patients compared with the other two groups (all, P<0.001). However, the three-dimensional strain and the regional longitudinal strain were lower in the hemodialysis patients than in the controls (P<0.01). In the hemodialysis patients and the control group, the longitudinal strain, circumferential strain, and radial strain were higher at the apical level than they were at the basal level and midlevels. A multivariate linear regression analysis showed that the blood urea nitrogen and creatinine levels were independently associated with the values of the global three-dimensional strain (β = -0.217, P = 0.000; β = -0.243, P = 0.011, respectively) and the longitudinal strain (β = -0.154, P = 0.032; β = -0.188, P = 0.029, respectively).
Three-dimensional speckle-tracking echocardiography may detect myocardial dysfunction in patients with uremia who have preserved LVEF. The global three-dimensional strain and the regional longitudinal strain appear to be superior in hemodialysis patients compared with nondialysis patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0100265</identifier><identifier>PMID: 24959903</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Cardiomyopathy ; Cardiovascular disease ; Case-Control Studies ; Circumferences ; Clinical medicine ; Creatinine ; Dialysis ; Drug dosages ; Echocardiography ; Echocardiography, Three-Dimensional ; Female ; Fistulae ; Heart ; Hemodialysis ; Hospitals ; Humans ; Kidney diseases ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; NMR ; Nuclear magnetic resonance ; Patients ; Population studies ; Regression analysis ; Renal Dialysis ; Reproducibility of Results ; Stroke Volume ; Studies ; Tracking ; Urea ; Uremia ; Uremia - complications ; Uremia - diagnosis ; Uremia - therapy ; Ventricle ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e100265-e100265</ispartof><rights>2014 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Chen et al 2014 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-1f18ed4f13916a70df6dfbf5eff697cc52879c79cb0cb3296870ca84a7f9e7993</citedby><cites>FETCH-LOGICAL-c526t-1f18ed4f13916a70df6dfbf5eff697cc52879c79cb0cb3296870ca84a7f9e7993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069011/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069011/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24959903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen, Xiongwen</contributor><creatorcontrib>Chen, Ran</creatorcontrib><creatorcontrib>Wu, Xia</creatorcontrib><creatorcontrib>Shen, Li-Jun</creatorcontrib><creatorcontrib>Wang, Bei</creatorcontrib><creatorcontrib>Ma, Ming-Ming</creatorcontrib><creatorcontrib>Yang, Yuan</creatorcontrib><creatorcontrib>Zhao, Bo-Wen</creatorcontrib><title>Left ventricular myocardial function in hemodialysis and nondialysis uremia patients: a three-dimensional speckle-tracking echocardiography study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Several studies have demonstrated that uremic patients who have preserved left ventricular ejection fraction (LVEF) could still have the potential for systolic dysfunction. The aim of this study was to assess the differences between the left ventricular (LV) myocardial function in hemodialysis and nondialysis uremic patients based on three-dimensional speckle-tracking echocardiography.
The study population consisted of 35 maintenance hemodialysis patients (the hemodialysis group), 30 uremic patients who were hospitalized for the creation of a primary arteriovenous fistula (the nondialysis group), and 32 healthy volunteers. All of the patients had normal left ventricular ejection fractions (i.e., 55% or greater). Three-dimensional speckle tracking echocardiography was performed to assess the left ventricle's global three-dimensional strain, regional longitudinal strain, circumferential strain, and radial strain.
The left ventricular regional longitudinal strain, radial strain, circumferential strain, and global three-dimensional strain were significantly decreased in the nondialysis patients compared with the other two groups (all, P<0.001). However, the three-dimensional strain and the regional longitudinal strain were lower in the hemodialysis patients than in the controls (P<0.01). In the hemodialysis patients and the control group, the longitudinal strain, circumferential strain, and radial strain were higher at the apical level than they were at the basal level and midlevels. A multivariate linear regression analysis showed that the blood urea nitrogen and creatinine levels were independently associated with the values of the global three-dimensional strain (β = -0.217, P = 0.000; β = -0.243, P = 0.011, respectively) and the longitudinal strain (β = -0.154, P = 0.032; β = -0.188, P = 0.029, respectively).
Three-dimensional speckle-tracking echocardiography may detect myocardial dysfunction in patients with uremia who have preserved LVEF. The global three-dimensional strain and the regional longitudinal strain appear to be superior in hemodialysis patients compared with nondialysis patients.</description><subject>Biology and Life Sciences</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Circumferences</subject><subject>Clinical medicine</subject><subject>Creatinine</subject><subject>Dialysis</subject><subject>Drug dosages</subject><subject>Echocardiography</subject><subject>Echocardiography, Three-Dimensional</subject><subject>Female</subject><subject>Fistulae</subject><subject>Heart</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Renal Dialysis</subject><subject>Reproducibility of Results</subject><subject>Stroke Volume</subject><subject>Studies</subject><subject>Tracking</subject><subject>Urea</subject><subject>Uremia</subject><subject>Uremia - complications</subject><subject>Uremia - diagnosis</subject><subject>Uremia - therapy</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkttu1DAQhiMEoqXwBggsccNNFh8SO-aiEqo4VKrEDVxbs85419vEDnZSaR-DNyZht6sWIVmyPf7nmxnrL4rXjK6YUOzDLk4pQLcaYsAVZZRyWT8pzpkWvJSciqcPzmfFi5x3lNaikfJ5ccYrXWtNxXnx-wbdSO4wjMnbqYNE-n20kFoPHXFTsKOPgfhAttjHJbjPPhMILQkxnO5Twt4DGWD0Myl_JEDGbUIsW99jyDNipuUB7W2H5ZjA3vqwIWi3h1Jxk2DY7kkep3b_snjmoMv46rhfFD-_fP5x9a28-f71-urTTWlrLseSOdZgWzkmNJOgaOtk69auRuekVnYWNUrbea2pXQuuZaOohaYC5TQqrcVF8fbAHbqYzfE3s2G10Kpmspaz4vqgaCPszJB8D2lvInjzNxDTxkAave3QCMZqqSXlXEDVWL5WVluhOFYVp0DZzLo8VpvWPbZ2-XDoHkEfvwS_NZt4ZyoqNWUL4P0RkOKvCfNoep8tdh0EjNPSd0UVE0wufb_7R_r_6aqDyqaYc0J3aoZRszjsPsssDjNHh81pbx4Ockq6t5T4A48s0xI</recordid><startdate>20140624</startdate><enddate>20140624</enddate><creator>Chen, Ran</creator><creator>Wu, Xia</creator><creator>Shen, Li-Jun</creator><creator>Wang, Bei</creator><creator>Ma, Ming-Ming</creator><creator>Yang, Yuan</creator><creator>Zhao, Bo-Wen</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140624</creationdate><title>Left ventricular myocardial function in hemodialysis and nondialysis uremia patients: a three-dimensional speckle-tracking echocardiography study</title><author>Chen, Ran ; Wu, Xia ; Shen, Li-Jun ; Wang, Bei ; Ma, Ming-Ming ; Yang, Yuan ; Zhao, Bo-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-1f18ed4f13916a70df6dfbf5eff697cc52879c79cb0cb3296870ca84a7f9e7993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biology and Life Sciences</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Circumferences</topic><topic>Clinical medicine</topic><topic>Creatinine</topic><topic>Dialysis</topic><topic>Drug dosages</topic><topic>Echocardiography</topic><topic>Echocardiography, Three-Dimensional</topic><topic>Female</topic><topic>Fistulae</topic><topic>Heart</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Renal Dialysis</topic><topic>Reproducibility of Results</topic><topic>Stroke Volume</topic><topic>Studies</topic><topic>Tracking</topic><topic>Urea</topic><topic>Uremia</topic><topic>Uremia - complications</topic><topic>Uremia - diagnosis</topic><topic>Uremia - therapy</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ran</creatorcontrib><creatorcontrib>Wu, Xia</creatorcontrib><creatorcontrib>Shen, Li-Jun</creatorcontrib><creatorcontrib>Wang, Bei</creatorcontrib><creatorcontrib>Ma, Ming-Ming</creatorcontrib><creatorcontrib>Yang, Yuan</creatorcontrib><creatorcontrib>Zhao, Bo-Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ran</au><au>Wu, Xia</au><au>Shen, Li-Jun</au><au>Wang, Bei</au><au>Ma, Ming-Ming</au><au>Yang, Yuan</au><au>Zhao, Bo-Wen</au><au>Chen, Xiongwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left ventricular myocardial function in hemodialysis and nondialysis uremia patients: a three-dimensional speckle-tracking echocardiography study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-06-24</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e100265</spage><epage>e100265</epage><pages>e100265-e100265</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Several studies have demonstrated that uremic patients who have preserved left ventricular ejection fraction (LVEF) could still have the potential for systolic dysfunction. The aim of this study was to assess the differences between the left ventricular (LV) myocardial function in hemodialysis and nondialysis uremic patients based on three-dimensional speckle-tracking echocardiography.
The study population consisted of 35 maintenance hemodialysis patients (the hemodialysis group), 30 uremic patients who were hospitalized for the creation of a primary arteriovenous fistula (the nondialysis group), and 32 healthy volunteers. All of the patients had normal left ventricular ejection fractions (i.e., 55% or greater). Three-dimensional speckle tracking echocardiography was performed to assess the left ventricle's global three-dimensional strain, regional longitudinal strain, circumferential strain, and radial strain.
The left ventricular regional longitudinal strain, radial strain, circumferential strain, and global three-dimensional strain were significantly decreased in the nondialysis patients compared with the other two groups (all, P<0.001). However, the three-dimensional strain and the regional longitudinal strain were lower in the hemodialysis patients than in the controls (P<0.01). In the hemodialysis patients and the control group, the longitudinal strain, circumferential strain, and radial strain were higher at the apical level than they were at the basal level and midlevels. A multivariate linear regression analysis showed that the blood urea nitrogen and creatinine levels were independently associated with the values of the global three-dimensional strain (β = -0.217, P = 0.000; β = -0.243, P = 0.011, respectively) and the longitudinal strain (β = -0.154, P = 0.032; β = -0.188, P = 0.029, respectively).
Three-dimensional speckle-tracking echocardiography may detect myocardial dysfunction in patients with uremia who have preserved LVEF. The global three-dimensional strain and the regional longitudinal strain appear to be superior in hemodialysis patients compared with nondialysis patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24959903</pmid><doi>10.1371/journal.pone.0100265</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Cardiomyopathy Cardiovascular disease Case-Control Studies Circumferences Clinical medicine Creatinine Dialysis Drug dosages Echocardiography Echocardiography, Three-Dimensional Female Fistulae Heart Hemodialysis Hospitals Humans Kidney diseases Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Mortality NMR Nuclear magnetic resonance Patients Population studies Regression analysis Renal Dialysis Reproducibility of Results Stroke Volume Studies Tracking Urea Uremia Uremia - complications Uremia - diagnosis Uremia - therapy Ventricle Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology |
| title | Left ventricular myocardial function in hemodialysis and nondialysis uremia patients: a three-dimensional speckle-tracking echocardiography study |
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