Nrf2 signaling contributes to the neuroprotective effects of urate against 6-OHDA toxicity

Mounting evidence shows that urate may become a biomarker of Parkinson's disease (PD) diagnosis and prognosis and a neuroprotectant candidate for PD therapy. However, the cellular and molecular mechanisms underlying its neuroprotective actions remain poorly understood. In this study, we showed...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e100286
Hauptverfasser:	Zhang, Ning, Shu, Hai-Yang, Huang, Tingting, Zhang, Qi-Lin, Li, Da, Zhang, Guan-Qun, Peng, Xiao-Yan, Liu, Chun-Feng, Luo, Wei-Feng, Hu, Li-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Active Transport, Cell Nucleus Antioxidants Augmentation Biology and Life Sciences Biomarkers Catalysis Cell culture Cell Line Cell Line, Tumor Damage accumulation Degradation Dopamine Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Enzymes Gene expression Gene Expression Regulation - drug effects Gene Knockdown Techniques Glutamate-cysteine ligase Glutathione Heme Heme oxygenase (decyclizing) Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - toxicity Immunoglobulins Kinases Laboratories Medicine and Health Sciences Models, Biological Molecular modelling Movement disorders Neurodegenerative diseases Neurology Neurons Neuroprotection Neuroprotective agents Neuroprotective Agents - pharmacology Neurosciences Neurotoxicity NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nuclear transport Oxidopamine - toxicity Oxygenase Parkinson's disease Parkinsons disease Pretreatment Protein Transport - drug effects Proteins Proteolysis - drug effects RNA Interference Rodents Signal Transduction Signaling siRNA Studies Toxicity Transcription Transcription factors Transcription, Genetic Translocation Ubiquitination Ubiquitination - drug effects Uric acid Uric Acid - pharmacology
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