A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells

Dendritic cells (DCs) are critical for regulating CD4 and CD8 T cell immunity, controlling Th1, Th2, and Th17 commitment, generating inducible Tregs, and mediating tolerance. It is believed that distinct DC subsets have evolved to control these different immune outcomes. However, how DC subsets moun...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e100613
Hauptverfasser:	Hancock, David G, Shklovskaya, Elena, Guy, Thomas V, Falsafi, Reza, Fjell, Chris D, Ritchie, William, Hancock, Robert E W, Fazekas de St Groth, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioinformatics Biology Biology and Life Sciences Cancer CD11b antigen CD11b Antigen - biosynthesis CD11b Antigen - immunology CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Computer and Information Sciences Cytokines Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dermatology Discipline Gene expression Gene Expression Regulation - drug effects Gene regulation Genomes Helper cells Immune Tolerance Immunity Immunity - drug effects Immunological tolerance Immunophenotyping Inflammation Kinases Lipopolysaccharides Lipopolysaccharides - administration & dosage Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Medicine Mice Modulators Network analysis Network hubs Ribonucleic acid RNA Rodents Signal transduction Signaling Spleen Stimulation Subpopulations Systems Biology T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - immunology Th1 Cells - drug effects Th1 Cells - immunology TLR4 protein Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - immunology Toll-like receptors Transcription factors Tumor necrosis factor-TNF
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