Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1

We have previously shown that celecoxib in combination with an antibiotic, increase the bacterial sensitivity to antibiotics. However, the underlying molecular mechanism remained elusive. Efficacy of the combinatorial treatment of celecoxib and ampicillin in vitro was evaluated on macrophage-phagocy...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99285-e99285
Hauptverfasser:	Annamanedi, Madhavi, Kalle, Arunasree M
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin Animal sciences Animals Anti-Bacterial Agents - administration & dosage Antibiotics Apoptosis Arthritis Bacteria Biology and Life Sciences Catalase Celecoxib Cell activation Combinatorial analysis Cyclooxygenase-2 Cytokines Diabetes Drug resistance Enzyme-linked immunosorbent assay Flow cytometry Gene expression Humans Inflammation Inflammation - drug therapy Inflammation - genetics Inhibition Interleukin 6 JNK protein Life sciences Macrophages Macrophages - drug effects Macrophages - microbiology Macrophages - pathology Medicine and Health Sciences Mice NF-κB protein Nitric oxide Nitric Oxide - metabolism Oxidative stress Oxidative Stress - genetics Peroxidase Phosphorylation Proteins Pyrazoles - administration & dosage Signal transduction Signal Transduction - drug effects Signaling SIRT1 protein Sirtuin 1 - biosynthesis Sirtuin 1 - metabolism Staphylococcal Infections - drug therapy Staphylococcal Infections - genetics Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Statistical analysis Sulfonamides - administration & dosage TLR2 protein Toll-like receptors Transcription
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