Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster

Peroxisomes are ubiquitous organelles that perform lipid and reactive oxygen species metabolism. Defects in peroxisome biogenesis cause peroxisome biogenesis disorders (PBDs). The most severe PBD, Zellweger syndrome, is characterized in part by neuronal dysfunction, craniofacial malformations, and l...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e100213-e100213
Hauptverfasser:	Faust, Joseph E, Manisundaram, Arvind, Ivanova, Pavlina T, Milne, Stephen B, Summerville, James B, Brown, H Alex, Wangler, Michael, Stern, Michael, McNew, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biochemistry Biology Biology and Life Sciences Biosynthesis Budding Clonal deletion Defects Deletion mutant Developmental stages Disruption Drosophila Drosophila melanogaster Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Energy metabolism Enzymes Etiology Gene expression Gene Knockdown Techniques Hypotonia Insects Larvae Lipid Metabolism Lipids Localization Medicine Membrane proteins Metabolism Muscle function Muscles Muscles - physiology Mutants Mutation Mutation - genetics Organ Specificity Organelles Oxidation Oxygen Peroxin Peroxisomal membrane protein Peroxisomes Peroxisomes - metabolism Pharmacology Physiology Proteins Pupa - physiology Pupariation Reactive oxygen species RNA Interference Rodents
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