Correlation analysis of EV71 detection and case severity in hand, foot, and mouth disease in the Hunan Province of China
An increase in the incidence of hand, foot and mouth disease (HFMD) cases has been observed in the Hunan province of mainland China since 2009 with a particularly higher level of severe cases in 2010-2012. Intestinal viruses of the picornaviridae family are responsible for the human syndrome associa...
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| creator | Gao, Li-Dong Hu, Shi-Xiong Zhang, Hong Luo, Kai-Wei Liu, Yun-Zhi Xu, Qiao-Hua Huang, Wei Deng, Zhi-Hong Zhou, Shuai-Feng Liu, Fu-Qiang Zhang, Fan Chen, Yu |
| description | An increase in the incidence of hand, foot and mouth disease (HFMD) cases has been observed in the Hunan province of mainland China since 2009 with a particularly higher level of severe cases in 2010-2012. Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71) and Coxsackievirus A16 (Cox A16) being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively). For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression. |
| doi_str_mv | 10.1371/journal.pone.0100003 |
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Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71) and Coxsackievirus A16 (Cox A16) being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively). For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0100003</identifier><identifier>PMID: 24941257</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>China - epidemiology ; Correlation ; Correlation analysis ; Disease control ; Disease Outbreaks ; Disease prevention ; Enterovirus ; Enterovirus A, Human - isolation & purification ; Enterovirus A, Human - pathogenicity ; Enterovirus A, Human - physiology ; Enterovirus Infections - epidemiology ; Enterovirus Infections - mortality ; Enterovirus Infections - pathology ; Enterovirus Infections - virology ; Enteroviruses ; Epidemiology ; Etiology ; Hand, Foot and Mouth Disease - epidemiology ; Hand, Foot and Mouth Disease - mortality ; Hand, Foot and Mouth Disease - pathology ; Hand, Foot and Mouth Disease - virology ; Hand-foot-and-mouth disease ; Health surveillance ; Human behavior ; Humans ; Incidence ; Infections ; Intestine ; Medical diagnosis ; Medical laboratories ; Medicine and Health Sciences ; Morbidity ; Mortality ; Outbreaks ; Pathogens ; Public health ; Risk factors ; Severity of Illness Index ; Survival Analysis ; Viruses</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e100003-e100003</ispartof><rights>2014 Gao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71) and Coxsackievirus A16 (Cox A16) being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively). For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression.</description><subject>China - epidemiology</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Disease control</subject><subject>Disease Outbreaks</subject><subject>Disease prevention</subject><subject>Enterovirus</subject><subject>Enterovirus A, Human - isolation & purification</subject><subject>Enterovirus A, Human - pathogenicity</subject><subject>Enterovirus A, Human - physiology</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - mortality</subject><subject>Enterovirus Infections - pathology</subject><subject>Enterovirus Infections - virology</subject><subject>Enteroviruses</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Hand, 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analysis of EV71 detection and case severity in hand, foot, and mouth disease in the Hunan Province of China</title><author>Gao, Li-Dong ; Hu, Shi-Xiong ; Zhang, Hong ; Luo, Kai-Wei ; Liu, Yun-Zhi ; Xu, Qiao-Hua ; Huang, Wei ; Deng, Zhi-Hong ; Zhou, Shuai-Feng ; Liu, Fu-Qiang ; Zhang, Fan ; Chen, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-19501ad95aae923aae271d807ac12bff0cc7b2a9d9b5f4a4aad1a71b965851963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>China - epidemiology</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Disease control</topic><topic>Disease Outbreaks</topic><topic>Disease prevention</topic><topic>Enterovirus</topic><topic>Enterovirus A, Human - isolation & purification</topic><topic>Enterovirus A, Human - pathogenicity</topic><topic>Enterovirus A, Human - physiology</topic><topic>Enterovirus Infections - 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One</addtitle><date>2014-06-18</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e100003</spage><epage>e100003</epage><pages>e100003-e100003</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>An increase in the incidence of hand, foot and mouth disease (HFMD) cases has been observed in the Hunan province of mainland China since 2009 with a particularly higher level of severe cases in 2010-2012. Intestinal viruses of the picornaviridae family are responsible for the human syndrome associated with HFMD with enterovirus 71 (EV71) and Coxsackievirus A16 (Cox A16) being the most common causative strains. HFMD cases associated with EV71 are generally more severe with an increased association of morbidity and mortality. In this study, the etiology surveillance data of HFMD cases in Hunan province from March 2010 to October 2012 were analyzed to determine if there is a statistically relevant linear correlation exists between the detection rate of EV71 in mild cases and the proportion of severe cases among all HFMD patients. As the cases progressed from mild to severe to fatal, the likelihood of EV71 detection increased (25.78%, 52.20% and 84.18%, respectively). For all cases in the timeframe evaluated in this study, the presence of virus was detected in 63.21% of cases; among cases showing positivity for virus, EV71 infection accounted for 50.14%. These results provide evidence to support the observed higher morbidity and mortality associated with this outbreak and emphasizes the importance of early detection in order to implement necessary prevention measures to mitigate disease progression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24941257</pmid><doi>10.1371/journal.pone.0100003</doi><oa>free_for_read</oa></addata></record> |
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| subjects | China - epidemiology Correlation Correlation analysis Disease control Disease Outbreaks Disease prevention Enterovirus Enterovirus A, Human - isolation & purification Enterovirus A, Human - pathogenicity Enterovirus A, Human - physiology Enterovirus Infections - epidemiology Enterovirus Infections - mortality Enterovirus Infections - pathology Enterovirus Infections - virology Enteroviruses Epidemiology Etiology Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - mortality Hand, Foot and Mouth Disease - pathology Hand, Foot and Mouth Disease - virology Hand-foot-and-mouth disease Health surveillance Human behavior Humans Incidence Infections Intestine Medical diagnosis Medical laboratories Medicine and Health Sciences Morbidity Mortality Outbreaks Pathogens Public health Risk factors Severity of Illness Index Survival Analysis Viruses |
| title | Correlation analysis of EV71 detection and case severity in hand, foot, and mouth disease in the Hunan Province of China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A37%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20analysis%20of%20EV71%20detection%20and%20case%20severity%20in%20hand,%20foot,%20and%20mouth%20disease%20in%20the%20Hunan%20Province%20of%20China&rft.jtitle=PloS%20one&rft.au=Gao,%20Li-Dong&rft.date=2014-06-18&rft.volume=9&rft.issue=6&rft.spage=e100003&rft.epage=e100003&rft.pages=e100003-e100003&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0100003&rft_dat=%3Cproquest_plos_%3E1539471373%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1537332866&rft_id=info:pmid/24941257&rft_doaj_id=oai_doaj_org_article_033ee3ddeca44ca189dba44b383c5b72&rfr_iscdi=true |