Mutant ubiquitin UBB+1 induces mitochondrial fusion by destabilizing mitochondrial fission-specific proteins and confers resistance to oxidative stress-induced cell death in astrocytic cells

Mutant ubiquitin UBB+1 is observed in a variety of aging-related neurodegenerative diseases and acts as a potent inhibitor of the ubiquitin proteasome system (UPS). In the present study, we investigated the relationship between impaired UPS (using ectopic expression of UBB+1) and mitochondrial dynam...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99937-e99937
Hauptverfasser:	Yim, Nambin, Ryu, Seung-Wook, Han, Eun Chun, Yoon, Jonghee, Choi, Kyungsun, Choi, Chulhee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Apoptosis Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biology and Life Sciences Cell death Cell Death - drug effects Cell Line Central nervous system Disease Ectopic expression Elongation Engineering Fission Fluorescence Fluorescence recovery after photobleaching Gene expression Glial cells Humans Hydrogen peroxide Immunocytochemistry Immunoglobulins Laboratories Lactacystin Medicine and Health Sciences Mitochondria Mitochondrial Dynamics - drug effects Mutant Proteins - metabolism Neurodegenerative diseases Neurological diseases Oxidation resistance Oxidative stress Oxidative Stress - drug effects Photobleaching Protease inhibitors Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors - pharmacology Proteasomes Proteinase inhibitors Proteins Recovery (Medical) Rodents Ubiquitin Ubiquitin - metabolism
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