Regulation of HIV-Gag expression and targeting to the endolysosomal/secretory pathway by the luminal domain of lysosomal-associated membrane protein (LAMP-1) enhance Gag-specific immune response

We have previously demonstrated that a DNA vaccine encoding HIV-p55gag in association with the lysosomal associated membrane protein-1 (LAMP-1) elicited a greater Gag-specific immune response, in comparison to a DNA encoding the native gag. In vitro studies have also demonstrated that LAMP/Gag was h...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99887-e99887
Hauptverfasser:	Godinho, Rodrigo Maciel da Costa, Matassoli, Flavio Lemos, Lucas, Carolina Gonçalves de Oliveira, Rigato, Paula Ordonhez, Gonçalves, Jorge Luiz Santos, Sato, Maria Notomi, Maciel, Jr, Milton, Peçanha, Ligia Maria Torres, August, J Thomas, Marques, Jr, Ernesto Torres de Azevedo, de Arruda, Luciana Barros
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS vaccines Analysis Animals Antibody response Antigen presentation B cells Biology and Life Sciences CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen Compartments Cytotoxicity Dendritic cells Deoxyribonucleic acid DNA DNA vaccines Endosomes - metabolism Exosomes - metabolism Female gag Gene Products, Human Immunodeficiency Virus - genetics gag Gene Products, Human Immunodeficiency Virus - immunology gag Gene Products, Human Immunodeficiency Virus - metabolism Gene expression Gene sequencing HEK293 Cells HIV Human immunodeficiency virus Humans Immune response Immune system Immunity Immunization Immunology Infections Infectious diseases LAMP-1 protein Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Lysosomal-Associated Membrane Protein 1 - chemistry Lysosomal-Associated Membrane Protein 1 - metabolism Lysosomes Lysosomes - metabolism Medicine and health sciences Membrane proteins Mice, Inbred BALB C mRNA Nucleotide sequence Pharmacology Plasmids Priming Protein expression Protein Structure, Tertiary Protein transport Proteins Proteolysis RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Secretory Pathway Structure-Activity Relationship T cells Traffic Transcription, Genetic Vaccines Viral infections
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