Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes

The effective integrated organization of processes in cardiac cells is achieved, in part, by the functional compartmentation of energy transfer processes. Earlier, using permeabilized cardiomyocytes, we demonstrated the existence of tight coupling between some of cardiomyocyte ATPases and glycolysis...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99413
Hauptverfasser:	Sepp, Mervi, Sokolova, Niina, Jugai, Svetlana, Mandel, Merle, Peterson, Pearu, Vendelin, Marko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animal models Animals ATP Bioenergetics Biological Transport, Active Biology Biology and Life Sciences Ca2+-transporting ATPase Calcium Calcium (reticular) Cardiac muscle Cardiomyocytes Cell Compartmentation Cell Membrane - enzymology Cell Membrane Permeability Compartmentation Coupling Cybernetics Data processing Electron transport Energy consumption Energy transfer Enzymes Experiments Female Glycolysis Heart Heart diseases Ischemia Kinases Kinetics L-Lactate Dehydrogenase - metabolism Laboratories Male Mathematical models Metabolism Mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism Models, Cardiovascular Myocytes, Cardiac - metabolism Na+/K+-exchanging ATPase Oligomycins - pharmacology Ouabain Ouabain - pharmacology Oxygen Consumption - drug effects Physical Sciences Plasma membranes Pyruvate kinase Pyruvate Kinase - metabolism Pyruvic acid Rats Rats, Wistar Regulation Research and Analysis Methods Respiration Restrictions Rodents Sarcoplasmic reticulum Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology Series (mathematics) Sodium Cyanide - pharmacology Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - physiology Studies Substrates Thapsigargin - pharmacology
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