Network analyses reveal pervasive functional regulation between proteases in the human protease web

Proteolytic processing is an irreversible posttranslational modification affecting a large portion of the proteome. Protease-cleaved mediators frequently exhibit altered activity, and biological pathways are often regulated by proteolytic processing. Many of these mechanisms have not been appreciate...

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Veröffentlicht in:	PLoS biology 2014-05, Vol.12 (5), p.e1001869-e1001869
Hauptverfasser:	Fortelny, Nikolaus, Cox, Jennifer H, Kappelhoff, Reinhild, Starr, Amanda E, Lange, Philipp F, Pavlidis, Paul, Overall, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin - metabolism Animals Biology and Life Sciences Cancer Computer and Information Sciences Enzymes Gene Expression Regulation Gene Regulatory Networks Humans Leukocyte Elastase - genetics Leukocyte Elastase - metabolism Mass spectrometry Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 8 - metabolism Medical research Mice Molecular weight Neutrophils - cytology Neutrophils - enzymology Physiological aspects Proteases Protein Interaction Mapping Protein research Proteins Proteolysis Proteome - genetics Proteome - metabolism Proteomics Regulation Research and Analysis Methods
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