Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense cause sleeping sickness in humans. T. b. b...

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Veröffentlicht in:	PLoS pathogens 2014-05, Vol.10 (5), p.e1004130
Hauptverfasser:	Alsford, Sam, Currier, Rachel B, Guerra-Assunção, José Afonso, Clark, Taane G, Horn, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins Biology and Life Sciences Blood Proteins - physiology Cathepsin L - genetics Cathepsin L - metabolism Cells, Cultured Cloning Cysteine Diseases Gene expression Genetic aspects Genomes Haptoglobin Health aspects Host-Pathogen Interactions - genetics Humans Immunity, Innate Livestock Medicine and Health Sciences Organisms, Genetically Modified Parasites Physiological aspects Proteins Proteolysis RNA Trypanocidal Agents - blood Trypanosoma brucei Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - metabolism Trypanosomiasis, African - blood Trypanosomiasis, African - immunology
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