Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum

Ca2+-dependent activator protein for secretion 2 (CAPS2) is a protein that is essential for enhanced release of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) from cerebellar granule cells. We previously identified dex3, a rare alternative splice variant of CAPS2, which is overre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99524-e99524
Hauptverfasser:	Sadakata, Tetsushi, Kakegawa, Wataru, Shinoda, Yo, Hosono, Mayu, Katoh-Semba, Ritsuko, Sekine, Yukiko, Sato, Yumi, Saruta, Chihiro, Ishizaki, Yasuki, Yuzaki, Michisuke, Kojima, Masami, Furuichi, Teiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Animals Animals, Newborn Anxiety Autism Axons Axons - metabolism Biology and Life Sciences Brain Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Calcium Calcium-Binding Proteins - metabolism Cell proliferation Cells, Cultured Cerebellar Cortex - metabolism Cerebellum Cerebellum - growth & development Cerebellum - metabolism Cerebellum - physiology Cerebellum - ultrastructure Cognition Dendritic branching Granular materials Granule cells Immunoglobulins Immunohistochemistry Localization Male Mice Mice, Inbred C57BL Nerve Fibers - metabolism Nerve Tissue Proteins - metabolism Neuronal Plasticity Neurosciences Neurotrophin 3 Neurotrophin 3 - metabolism Paired-pulse facilitation Phosphorylation Physiology Protein Isoforms - metabolism Protein Transport Proteins Purkinje cells Purkinje Cells - metabolism Purkinje Cells - pathology Rodents Science Secretion Signal transduction Social behavior Social interactions Subcellular Fractions - metabolism Synapses Synaptic Vesicles - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!