Evaluation and validation of a method for determining platelet catecholamine in patients with obstructive sleep apnea and arterial hypertension
Measurements of plasma and urinary catecholamine are susceptible to confounding factors that influence the results, complicating the interpretation of sympathetic nervous system (SNS) activity in the Obstructive sleep apnea (OSA) and arterial hypertension (HYP) conditions. In this study, we validate...
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| Veröffentlicht in: | PloS one 2014-06, Vol.9 (6), p.e98407-e98407 |
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| description | Measurements of plasma and urinary catecholamine are susceptible to confounding factors that influence the results, complicating the interpretation of sympathetic nervous system (SNS) activity in the Obstructive sleep apnea (OSA) and arterial hypertension (HYP) conditions.
In this study, we validated a test for platelet catecholamine and compared the catecholamine levels (adrenaline and noradrenaline) in urine, plasma and platelets in patients with OSA and HYP compared with controls.
In the validation, 30 healthy, nonsmoking volunteers who were not currently undergoing treatment or medication were selected as the control group. One hundred fifty-four individuals (114 OSA, 40 non-OSA) were consecutively selected from the outpatient clinic of the Sleep Institute and underwent clinical, polysomnographic and laboratory evaluation, including the urinary, plasma and platelet levels of adrenaline (AD) and noradrenaline (NA). Patients were then allocated to groups according to the presence of OSA and/or hypertension.
A logistic regression model, controlled for age and BMI, showed that urinary AD and urinary NA were risk factors in the OSA+HYP group and the HYP group; however, the model showed higher levels of platelet NA for OSA without HYP. After 1 year of CPAP (continuous upper airway pressure) treatment, patients (n = 9) presented lower levels of urinary NA (p = 0.04) and platelet NA (p = 0.05).
Urinary NA and AD levels were significantly associated with the condition of hypertension with and without OSA, whereas platelet NA with OSA without comorbidity. These findings suggest that platelet catecholamine levels might reflect nocturnal sympathetic activation in OSA patients without hypertension. |
| doi_str_mv | 10.1371/journal.pone.0098407 |
| format | Article |
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In this study, we validated a test for platelet catecholamine and compared the catecholamine levels (adrenaline and noradrenaline) in urine, plasma and platelets in patients with OSA and HYP compared with controls.
In the validation, 30 healthy, nonsmoking volunteers who were not currently undergoing treatment or medication were selected as the control group. One hundred fifty-four individuals (114 OSA, 40 non-OSA) were consecutively selected from the outpatient clinic of the Sleep Institute and underwent clinical, polysomnographic and laboratory evaluation, including the urinary, plasma and platelet levels of adrenaline (AD) and noradrenaline (NA). Patients were then allocated to groups according to the presence of OSA and/or hypertension.
A logistic regression model, controlled for age and BMI, showed that urinary AD and urinary NA were risk factors in the OSA+HYP group and the HYP group; however, the model showed higher levels of platelet NA for OSA without HYP. After 1 year of CPAP (continuous upper airway pressure) treatment, patients (n = 9) presented lower levels of urinary NA (p = 0.04) and platelet NA (p = 0.05).
Urinary NA and AD levels were significantly associated with the condition of hypertension with and without OSA, whereas platelet NA with OSA without comorbidity. These findings suggest that platelet catecholamine levels might reflect nocturnal sympathetic activation in OSA patients without hypertension.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098407</identifier><identifier>PMID: 24911183</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Apnea ; Biology and Life Sciences ; Blood Chemical Analysis - methods ; Blood platelets ; Blood Platelets - chemistry ; Body mass ; Care and treatment ; Catecholamine ; Catecholamines ; Catecholamines - blood ; Comparative analysis ; Continuous Positive Airway Pressure ; Control methods ; Disease ; Drugs ; Epinephrine ; Evaluation ; Experiments ; Female ; Humans ; Hypertension ; Hypertension - complications ; Logistic Models ; Male ; Medicine and Health Sciences ; Methods ; Middle Aged ; Noradrenaline ; Norepinephrine ; Patients ; Physical Sciences ; Platelets ; Psychobiology ; Regression models ; Respiratory tract ; Risk analysis ; Risk factors ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - therapy ; Sleep disorders ; Studies ; Sympathetic nervous system ; Urine ; Young Adult</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e98407-e98407</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Feres et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Feres et al 2014 Feres et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e527e5d11cc5f1e31e69e940deb13917ae1b77efff9cf5a50f4d2e533dc729963</citedby><cites>FETCH-LOGICAL-c692t-e527e5d11cc5f1e31e69e940deb13917ae1b77efff9cf5a50f4d2e533dc729963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049580/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049580/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24911183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Najbauer, Joseph</contributor><creatorcontrib>Feres, Marcia C</creatorcontrib><creatorcontrib>Cintra, Fatima D</creatorcontrib><creatorcontrib>Rizzi, Camila F</creatorcontrib><creatorcontrib>Mello-Fujita, Luciane</creatorcontrib><creatorcontrib>Lino de Souza, Altay A</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Poyares, Dalva</creatorcontrib><title>Evaluation and validation of a method for determining platelet catecholamine in patients with obstructive sleep apnea and arterial hypertension</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Measurements of plasma and urinary catecholamine are susceptible to confounding factors that influence the results, complicating the interpretation of sympathetic nervous system (SNS) activity in the Obstructive sleep apnea (OSA) and arterial hypertension (HYP) conditions.
In this study, we validated a test for platelet catecholamine and compared the catecholamine levels (adrenaline and noradrenaline) in urine, plasma and platelets in patients with OSA and HYP compared with controls.
In the validation, 30 healthy, nonsmoking volunteers who were not currently undergoing treatment or medication were selected as the control group. One hundred fifty-four individuals (114 OSA, 40 non-OSA) were consecutively selected from the outpatient clinic of the Sleep Institute and underwent clinical, polysomnographic and laboratory evaluation, including the urinary, plasma and platelet levels of adrenaline (AD) and noradrenaline (NA). Patients were then allocated to groups according to the presence of OSA and/or hypertension.
A logistic regression model, controlled for age and BMI, showed that urinary AD and urinary NA were risk factors in the OSA+HYP group and the HYP group; however, the model showed higher levels of platelet NA for OSA without HYP. After 1 year of CPAP (continuous upper airway pressure) treatment, patients (n = 9) presented lower levels of urinary NA (p = 0.04) and platelet NA (p = 0.05).
Urinary NA and AD levels were significantly associated with the condition of hypertension with and without OSA, whereas platelet NA with OSA without comorbidity. These findings suggest that platelet catecholamine levels might reflect nocturnal sympathetic activation in OSA patients without hypertension.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Apnea</subject><subject>Biology and Life Sciences</subject><subject>Blood Chemical Analysis - methods</subject><subject>Blood platelets</subject><subject>Blood Platelets - chemistry</subject><subject>Body mass</subject><subject>Care and treatment</subject><subject>Catecholamine</subject><subject>Catecholamines</subject><subject>Catecholamines - blood</subject><subject>Comparative analysis</subject><subject>Continuous Positive Airway Pressure</subject><subject>Control methods</subject><subject>Disease</subject><subject>Drugs</subject><subject>Epinephrine</subject><subject>Evaluation</subject><subject>Experiments</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Noradrenaline</subject><subject>Norepinephrine</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Platelets</subject><subject>Psychobiology</subject><subject>Regression models</subject><subject>Respiratory tract</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><subject>Studies</subject><subject>Sympathetic nervous system</subject><subject>Urine</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbF39B6IBQfRi12SSzGxuhFKqFgoFv25DJjnZSckm00mm2l_hXzbb3Zau9ELmIl_PeU_OOzlV9ZLgBaEt-XARpzEovxhigAXGYslw-6g6JILW86bG9PG9-UH1LKULjDldNs3T6qBmghCypIfVn5Mr5SeVXQxIBYPKypntMlqk0BpyHw2ycUQGMoxrF1xYocGrDB4y0mXUffSqHAByAQ0lGEJO6JfLPYpdyuOks7sClDzAgNQQQN2kUmPRc8qj_nqAMg-pZH1ePbHKJ3ixG2fVj08n34-_zM_OP58eH53NdSPqPAdet8ANIVpzS4ASaAQIhg10hArSKiBd24K1VmjLFceWmRo4pUa3tRANnVWvt7qDj0nuvEyScMooaTgXhTjdEiaqCzmMbq3GaxmVkzcbcVzJUoHTHqQ1Xa2FqttOsXIH1gFnSxCaUsW4Ka7Pqo-7bFO3BqOLQaPye6L7J8H1chWvJMNM8CUuAu92AmO8nCBluXZJg_cqQJy2924F5g0r6Jt_0Ier21ErVQpwwcaSV29E5REjy4aympJCLR6gymdg7XR5eNaV_b2A93sBhcnwO6_UlJI8_fb1_9nzn_vs23tsD8rnPkU_bR5q2gfZFtRjTGkEe2cywXLTN7duyE3fyF3flLBX93_QXdBto9C_K98Whg</recordid><startdate>20140609</startdate><enddate>20140609</enddate><creator>Feres, Marcia C</creator><creator>Cintra, Fatima D</creator><creator>Rizzi, Camila F</creator><creator>Mello-Fujita, Luciane</creator><creator>Lino de Souza, Altay A</creator><creator>Tufik, Sergio</creator><creator>Poyares, Dalva</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140609</creationdate><title>Evaluation and validation of a method for determining platelet catecholamine in patients with obstructive sleep apnea and arterial hypertension</title><author>Feres, Marcia C ; Cintra, Fatima D ; Rizzi, Camila F ; Mello-Fujita, Luciane ; Lino de Souza, Altay A ; Tufik, Sergio ; Poyares, Dalva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e527e5d11cc5f1e31e69e940deb13917ae1b77efff9cf5a50f4d2e533dc729963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Apnea</topic><topic>Biology and Life Sciences</topic><topic>Blood Chemical Analysis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feres, Marcia C</au><au>Cintra, Fatima D</au><au>Rizzi, Camila F</au><au>Mello-Fujita, Luciane</au><au>Lino de Souza, Altay A</au><au>Tufik, Sergio</au><au>Poyares, Dalva</au><au>Najbauer, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation and validation of a method for determining platelet catecholamine in patients with obstructive sleep apnea and arterial hypertension</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-06-09</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e98407</spage><epage>e98407</epage><pages>e98407-e98407</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Measurements of plasma and urinary catecholamine are susceptible to confounding factors that influence the results, complicating the interpretation of sympathetic nervous system (SNS) activity in the Obstructive sleep apnea (OSA) and arterial hypertension (HYP) conditions.
In this study, we validated a test for platelet catecholamine and compared the catecholamine levels (adrenaline and noradrenaline) in urine, plasma and platelets in patients with OSA and HYP compared with controls.
In the validation, 30 healthy, nonsmoking volunteers who were not currently undergoing treatment or medication were selected as the control group. One hundred fifty-four individuals (114 OSA, 40 non-OSA) were consecutively selected from the outpatient clinic of the Sleep Institute and underwent clinical, polysomnographic and laboratory evaluation, including the urinary, plasma and platelet levels of adrenaline (AD) and noradrenaline (NA). Patients were then allocated to groups according to the presence of OSA and/or hypertension.
A logistic regression model, controlled for age and BMI, showed that urinary AD and urinary NA were risk factors in the OSA+HYP group and the HYP group; however, the model showed higher levels of platelet NA for OSA without HYP. After 1 year of CPAP (continuous upper airway pressure) treatment, patients (n = 9) presented lower levels of urinary NA (p = 0.04) and platelet NA (p = 0.05).
Urinary NA and AD levels were significantly associated with the condition of hypertension with and without OSA, whereas platelet NA with OSA without comorbidity. These findings suggest that platelet catecholamine levels might reflect nocturnal sympathetic activation in OSA patients without hypertension.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24911183</pmid><doi>10.1371/journal.pone.0098407</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-06, Vol.9 (6), p.e98407-e98407 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1534316559 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Apnea Biology and Life Sciences Blood Chemical Analysis - methods Blood platelets Blood Platelets - chemistry Body mass Care and treatment Catecholamine Catecholamines Catecholamines - blood Comparative analysis Continuous Positive Airway Pressure Control methods Disease Drugs Epinephrine Evaluation Experiments Female Humans Hypertension Hypertension - complications Logistic Models Male Medicine and Health Sciences Methods Middle Aged Noradrenaline Norepinephrine Patients Physical Sciences Platelets Psychobiology Regression models Respiratory tract Risk analysis Risk factors Sleep Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - therapy Sleep disorders Studies Sympathetic nervous system Urine Young Adult |
| title | Evaluation and validation of a method for determining platelet catecholamine in patients with obstructive sleep apnea and arterial hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T09%3A58%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20and%20validation%20of%20a%20method%20for%20determining%20platelet%20catecholamine%20in%20patients%20with%20obstructive%20sleep%20apnea%20and%20arterial%20hypertension&rft.jtitle=PloS%20one&rft.au=Feres,%20Marcia%20C&rft.date=2014-06-09&rft.volume=9&rft.issue=6&rft.spage=e98407&rft.epage=e98407&rft.pages=e98407-e98407&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0098407&rft_dat=%3Cgale_plos_%3EA418634231%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1534316559&rft_id=info:pmid/24911183&rft_galeid=A418634231&rft_doaj_id=oai_doaj_org_article_fdb2c9a27ba440d4be548e9c33a45d05&rfr_iscdi=true |