Purification and characterization of a novel and robust L-asparaginase having low-glutaminase activity from Bacillus licheniformis: in vitro evaluation of anti-cancerous properties

L-asparaginase having low glutaminase has been a key therapeutic agent in the treatment of acute lymphpoblastic leukemia (A.L.L). In the present study, an extracellular L-asparaginase with low glutaminase activity, produced by Bacillus licheniformis was purified to homogeneity. Protein was found to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99037
Hauptverfasser:	Mahajan, Richi V, Kumar, Vinod, Rajendran, Vinoth, Saran, Saurabh, Ghosh, Prahlad C, Saxena, Rajendra Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Asparaginase Asparaginase - chemistry Asparaginase - isolation & purification Asparaginase - metabolism Asparaginase - pharmacology Asparagine Bacillus - chemistry Bacillus - enzymology Bacillus licheniformis Biochemistry Biology and Life Sciences Biotechnology Blood banks Cations Cell Line, Tumor Cellulose Chemical compounds Chemical properties CHO Cells Cricetulus Cytotoxicity Divalent cations E coli Enzyme Stability Enzymes Erythrocytes Escherichia coli Fluorescence Glutaminase Glutaminase - chemistry Glutaminase - isolation & purification Glutaminase - metabolism Glutaminase - pharmacology Health aspects Homogeneity Humans L-asparaginase Leukemia Neoplasms - drug therapy pH effects Pharmacology Proteins Reagents Red blood cells Spectroscopy Substrate Specificity Substrates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!