Dormancy of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia

A hypoxic microenvironment in tumors has been recognized as a cause of malignancy or resistance to various cancer therapies. In contrast to recent progress in understanding the acute response of cancer cells to hypoxia, the characteristics of tumor cells in chronic hypoxia remain elusive. We have id...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e98858-e98858
Hauptverfasser:	Endo, Hiroko, Okuyama, Hiroaki, Ohue, Masayuki, Inoue, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis ATP Biochemistry Biotechnology Cancer Cancer cells Cell culture Cell cycle Cell death Cell growth Cell Hypoxia Cell Line, Tumor Cell proliferation Cell Survival Chemotherapy Chronic illnesses Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Dormancy Down-Regulation Drug Resistance, Neoplasm Energy demand Energy Metabolism Enzyme Activation Gene expression Health aspects Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Intercellular Signaling Peptides and Proteins - deficiency Intracellular Space - metabolism Kinases Malignancy Medicine and Health Sciences Metabolism Oxygen Pancreatic cancer Pancreatic Neoplasms - pathology Phosphorylation Protein synthesis Proteins Proto-Oncogene Proteins c-akt - metabolism Radiation therapy Regulatory mechanisms (biology) Rodents Signal Transduction Studies Time Factors Tumor cell lines Tumor cells Tumor Microenvironment Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!