Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown

In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much train...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98439-e98439
Hauptverfasser:	Centanni, Tracy M, Chen, Fuyi, Booker, Anne M, Engineer, Crystal T, Sloan, Andrew M, Rennaker, Robert L, LoTurco, Joseph J, Kilgard, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics Animals Background noise Behavior Behavioral plasticity Biology and life sciences Cell Adhesion Molecules - deficiency Cell Adhesion Molecules - genetics Consonants (speech) Cortex Discrimination, Psychological - physiology Dyslexia Dyslexia - genetics Female Frequency dependence Gene expression Genes Genetic engineering Hypotheses Information processing Latency Male Medicine and Health Sciences Nervous system Neural plasticity Neurobiology Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurons Neuroplasticity Neurosciences Phonemes Phonetics Phonology Physiology Plasticity Proteins Psychotherapy Rats Rats, Wistar Research and Analysis Methods RNA Interference RNA-mediated interference Rodents Social Sciences Sound Sound processing Speech Speech perception Speech Perception - genetics Speech Perception - physiology Speech sounds Studies Time Factors Training Trends Variability
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