Sequence variations of full-length hepatitis B virus genomes in Chinese patients with HBsAg-negative hepatitis B infection

The underlying mechanism of HBsAg-negative hepatitis B virus (HBV) infection is notoriously difficult to elucidate because of the extremely low DNA levels which define the condition. We used a highly efficient amplification method to overcome this obstacle and achieved our aim which was to identify...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e99028-e99028
Hauptverfasser:	Huang, Fung-Yu, Wong, Danny Ka-Ho, Seto, Wai-Kay, Zhang, An-Ye, Lee, Cheuk-Kwong, Lin, Che-Kit, Fung, James, Lai, Ching-Lung, Yuen, Man-Fung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino acids Amplification Antigens Biology and Life Sciences Biopsy Blood transfusions China Defects Deoxyribonucleic acid DNA DNA Mutational Analysis DNA sequencing DNA, Viral - chemistry DNA, Viral - metabolism Female Gene expression Gene sequencing Genetic Variation Genome, Viral Genomes Genomics Genotype Genotype & phenotype Health aspects Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis B Surface Antigens - genetics Hepatitis B virus Hepatitis B virus - classification Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - virology Hepatology Hospitals Humans Infection Infections Laboratories Liver Liver - pathology Liver - virology Liver cancer Male Medicine Medicine and Health Sciences Middle Aged Missense mutation Mutation Nucleic Acid Conformation Patients Phylogeny Promoter Regions, Genetic Proteins Regulatory sequences RNA RNA, Viral - chemistry Sequence Analysis, DNA Splicing Transcription Viruses
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