A meta-analysis of red yeast rice: an effective and relatively safe alternative approach for dyslipidemia
To explore whether red yeast rice is a safe and effective alternative approach for dyslipidemia. Pubmed, the Cochrane Library, EBSCO host, Chinese VIP Information (VIP), China National Knowledge Infrastructure (CNKI), Wanfang Databases were searched for appropriate articles. Randomized trials of RYR...
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| creator | Li, Yinhua Jiang, Long Jia, Zhangrong Xin, Wei Yang, Shiwei Yang, Qiu Wang, Luya |
| description | To explore whether red yeast rice is a safe and effective alternative approach for dyslipidemia.
Pubmed, the Cochrane Library, EBSCO host, Chinese VIP Information (VIP), China National Knowledge Infrastructure (CNKI), Wanfang Databases were searched for appropriate articles. Randomized trials of RYR (not including Xuezhikang and Zhibituo) and placebo as control in patients with dyslipidemia were considered. Two authors read all papers and independently extracted all relevant information. The primary outcomes were serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The secondary outcomes were increased levels of alanine transaminase, aspartate aminotransferase, creatine kinase, creatinine and fasting blood glucose.
A total of 13 randomized, placebo-controlled trials containing 804 participants were analyzed. Red yeast rice exhibited significant lowering effects on serum TC [WMD = -0.97 (95% CI: -1.13, -0.80) mmol/L, P |
| doi_str_mv | 10.1371/journal.pone.0098611 |
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Pubmed, the Cochrane Library, EBSCO host, Chinese VIP Information (VIP), China National Knowledge Infrastructure (CNKI), Wanfang Databases were searched for appropriate articles. Randomized trials of RYR (not including Xuezhikang and Zhibituo) and placebo as control in patients with dyslipidemia were considered. Two authors read all papers and independently extracted all relevant information. The primary outcomes were serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The secondary outcomes were increased levels of alanine transaminase, aspartate aminotransferase, creatine kinase, creatinine and fasting blood glucose.
A total of 13 randomized, placebo-controlled trials containing 804 participants were analyzed. Red yeast rice exhibited significant lowering effects on serum TC [WMD = -0.97 (95% CI: -1.13, -0.80) mmol/L, P<0.001], TG [WMD = -0.23 (95% CI: -0.31, -0.14) mmol/L, P<0.001], and LDL-C [WMD = -0.87 (95% CI: -1.03, -0.71) mmol/L, P<0.001] but no significant increasing effect on HDL-C [WMD = 0.08 (95% CI: -0.02, 0.19) mmol/L, P = 0.11] compared with placebo. No serious side effects were reported in all trials.
The meta-analysis suggests that red yeast rice is an effective and relatively safe approach for dyslipidemia. However, further long-term, rigorously designed randomized controlled trials are still warranted before red yeast rice could be recommended to patients with dyslipidemia, especially as an alternative to statins.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098611</identifier><identifier>PMID: 24897342</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alanine ; Alanine transaminase ; Analysis ; Antilipemic agents ; Arteriosclerosis ; Aspartate ; Aspartate aminotransferase ; Biological Products - administration & dosage ; Biological Products - adverse effects ; Biological Products - therapeutic use ; Biology and Life Sciences ; Blood glucose ; Cardiovascular disease ; Cholesterol ; Clinical trials ; Complementary Therapies ; Creatine ; Creatine kinase ; Creatinine ; Diabetes ; Dietary supplements ; Dyslipidemia ; Dyslipidemias - blood ; Dyslipidemias - drug therapy ; Heart ; Herbal medicine ; High density lipoprotein ; Hospitals ; Humans ; Lipids ; Lipids - blood ; Liver Function Tests ; Low density lipoprotein ; Low density lipoproteins ; Medicine and Health Sciences ; Meta-analysis ; Metabolic disorders ; Monascus purpureus ; Mortality ; Oryza ; Patients ; Physical Sciences ; Preventive medicine ; Publication Bias ; Randomization ; Randomized Controlled Trials as Topic ; Research and Analysis Methods ; Rice ; Ryanodine receptors ; Side effects ; Statins ; Studies ; Transaminase ; Treatment Outcome ; Triglycerides ; Vasoactive intestinal peptide ; Weapons of mass destruction ; Yeast</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e98611</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Li et al 2014 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-1d5ac0b840e19cd6d37ff4d0d185f3f2715e48e8b7de09dae42aa40fa114f64b3</citedby><cites>FETCH-LOGICAL-c692t-1d5ac0b840e19cd6d37ff4d0d185f3f2715e48e8b7de09dae42aa40fa114f64b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045580/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045580/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24897342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Calabresi, Laura</contributor><creatorcontrib>Li, Yinhua</creatorcontrib><creatorcontrib>Jiang, Long</creatorcontrib><creatorcontrib>Jia, Zhangrong</creatorcontrib><creatorcontrib>Xin, Wei</creatorcontrib><creatorcontrib>Yang, Shiwei</creatorcontrib><creatorcontrib>Yang, Qiu</creatorcontrib><creatorcontrib>Wang, Luya</creatorcontrib><title>A meta-analysis of red yeast rice: an effective and relatively safe alternative approach for dyslipidemia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To explore whether red yeast rice is a safe and effective alternative approach for dyslipidemia.
Pubmed, the Cochrane Library, EBSCO host, Chinese VIP Information (VIP), China National Knowledge Infrastructure (CNKI), Wanfang Databases were searched for appropriate articles. Randomized trials of RYR (not including Xuezhikang and Zhibituo) and placebo as control in patients with dyslipidemia were considered. Two authors read all papers and independently extracted all relevant information. The primary outcomes were serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The secondary outcomes were increased levels of alanine transaminase, aspartate aminotransferase, creatine kinase, creatinine and fasting blood glucose.
A total of 13 randomized, placebo-controlled trials containing 804 participants were analyzed. Red yeast rice exhibited significant lowering effects on serum TC [WMD = -0.97 (95% CI: -1.13, -0.80) mmol/L, P<0.001], TG [WMD = -0.23 (95% CI: -0.31, -0.14) mmol/L, P<0.001], and LDL-C [WMD = -0.87 (95% CI: -1.03, -0.71) mmol/L, P<0.001] but no significant increasing effect on HDL-C [WMD = 0.08 (95% CI: -0.02, 0.19) mmol/L, P = 0.11] compared with placebo. No serious side effects were reported in all trials.
The meta-analysis suggests that red yeast rice is an effective and relatively safe approach for dyslipidemia. However, further long-term, rigorously designed randomized controlled trials are still warranted before red yeast rice could be recommended to patients with dyslipidemia, especially as an alternative to statins.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Analysis</subject><subject>Antilipemic agents</subject><subject>Arteriosclerosis</subject><subject>Aspartate</subject><subject>Aspartate aminotransferase</subject><subject>Biological Products - administration & dosage</subject><subject>Biological Products - adverse effects</subject><subject>Biological Products - therapeutic use</subject><subject>Biology and Life Sciences</subject><subject>Blood glucose</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Complementary Therapies</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Dietary supplements</subject><subject>Dyslipidemia</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - drug therapy</subject><subject>Heart</subject><subject>Herbal medicine</subject><subject>High density lipoprotein</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Liver Function Tests</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metabolic disorders</subject><subject>Monascus purpureus</subject><subject>Mortality</subject><subject>Oryza</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Preventive medicine</subject><subject>Publication Bias</subject><subject>Randomization</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Research and Analysis Methods</subject><subject>Rice</subject><subject>Ryanodine receptors</subject><subject>Side effects</subject><subject>Statins</subject><subject>Studies</subject><subject>Transaminase</subject><subject>Treatment Outcome</subject><subject>Triglycerides</subject><subject>Vasoactive intestinal peptide</subject><subject>Weapons of mass destruction</subject><subject>Yeast</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluL2zAQhU1p6V7af1BaQ6HQh6SSJdtyHwph6SWwsNDbq5hIo0TBsVxJWZp_v3LjXWJooejB0ug7R8P4ZNkLSuaU1fTd1u19B-28dx3OCWlERemj7Jw2rJhVBWGPT_Zn2UUIW0JKJqrqaXZWcNHUjBfnmV3kO4wwg2R1CDbkzuQedX5ACDH3VuH7HLocjUEV7S2mg05AC8OhPeQBTKq1EVMvx_u-9w7UJjfO5_oQWttbjTsLz7InBtqAz8fvZfbj08fvV19m1zefl1eL65mqmiLOqC5BkZXgBGmjdKVZbQzXRFNRGmaKmpbIBYpVrZE0GpAXAJwYoJSbiq_YZfbq6Nu3LshxSkHSkhVVycuSJGJ5JLSDrey93YE_SAdW_ik4v5bgo1UtylqQShEuCGjNkTAhoExvEIOUmmSWvD6Mr-1XO9QKu-ihnZhObzq7kWt3KzlJcjE083o08O7XHkP8R8sjtYbUle2MS2ZqZ4OSC06rpi55XSdq_hcqreEHqJQTY1N9Ing7ESQm4u-4hn0Icvnt6_-zNz-n7JsTdoMpIJvg2n20rgtTkB9B5V0IHs3D5CiRQ8zvpyGHmMsx5kn28nTqD6L7XLM7ozD42Q</recordid><startdate>20140604</startdate><enddate>20140604</enddate><creator>Li, 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meta-analysis of red yeast rice: an effective and relatively safe alternative approach for dyslipidemia</title><author>Li, Yinhua ; Jiang, Long ; Jia, Zhangrong ; Xin, Wei ; Yang, Shiwei ; Yang, Qiu ; Wang, Luya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-1d5ac0b840e19cd6d37ff4d0d185f3f2715e48e8b7de09dae42aa40fa114f64b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Analysis</topic><topic>Antilipemic agents</topic><topic>Arteriosclerosis</topic><topic>Aspartate</topic><topic>Aspartate aminotransferase</topic><topic>Biological Products - administration & dosage</topic><topic>Biological Products - adverse effects</topic><topic>Biological Products - therapeutic use</topic><topic>Biology and Life Sciences</topic><topic>Blood glucose</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Clinical trials</topic><topic>Complementary Therapies</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Dietary supplements</topic><topic>Dyslipidemia</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - drug therapy</topic><topic>Heart</topic><topic>Herbal medicine</topic><topic>High density lipoprotein</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Liver Function Tests</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Medicine and Health Sciences</topic><topic>Meta-analysis</topic><topic>Metabolic disorders</topic><topic>Monascus purpureus</topic><topic>Mortality</topic><topic>Oryza</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Preventive medicine</topic><topic>Publication Bias</topic><topic>Randomization</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Research and Analysis Methods</topic><topic>Rice</topic><topic>Ryanodine receptors</topic><topic>Side effects</topic><topic>Statins</topic><topic>Studies</topic><topic>Transaminase</topic><topic>Treatment Outcome</topic><topic>Triglycerides</topic><topic>Vasoactive intestinal peptide</topic><topic>Weapons of mass destruction</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yinhua</creatorcontrib><creatorcontrib>Jiang, Long</creatorcontrib><creatorcontrib>Jia, Zhangrong</creatorcontrib><creatorcontrib>Xin, Wei</creatorcontrib><creatorcontrib>Yang, Shiwei</creatorcontrib><creatorcontrib>Yang, Qiu</creatorcontrib><creatorcontrib>Wang, Luya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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One</addtitle><date>2014-06-04</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e98611</spage><pages>e98611-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To explore whether red yeast rice is a safe and effective alternative approach for dyslipidemia.
Pubmed, the Cochrane Library, EBSCO host, Chinese VIP Information (VIP), China National Knowledge Infrastructure (CNKI), Wanfang Databases were searched for appropriate articles. Randomized trials of RYR (not including Xuezhikang and Zhibituo) and placebo as control in patients with dyslipidemia were considered. Two authors read all papers and independently extracted all relevant information. The primary outcomes were serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The secondary outcomes were increased levels of alanine transaminase, aspartate aminotransferase, creatine kinase, creatinine and fasting blood glucose.
A total of 13 randomized, placebo-controlled trials containing 804 participants were analyzed. Red yeast rice exhibited significant lowering effects on serum TC [WMD = -0.97 (95% CI: -1.13, -0.80) mmol/L, P<0.001], TG [WMD = -0.23 (95% CI: -0.31, -0.14) mmol/L, P<0.001], and LDL-C [WMD = -0.87 (95% CI: -1.03, -0.71) mmol/L, P<0.001] but no significant increasing effect on HDL-C [WMD = 0.08 (95% CI: -0.02, 0.19) mmol/L, P = 0.11] compared with placebo. No serious side effects were reported in all trials.
The meta-analysis suggests that red yeast rice is an effective and relatively safe approach for dyslipidemia. However, further long-term, rigorously designed randomized controlled trials are still warranted before red yeast rice could be recommended to patients with dyslipidemia, especially as an alternative to statins.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24897342</pmid><doi>10.1371/journal.pone.0098611</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-06, Vol.9 (6), p.e98611 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1532654550 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alanine Alanine transaminase Analysis Antilipemic agents Arteriosclerosis Aspartate Aspartate aminotransferase Biological Products - administration & dosage Biological Products - adverse effects Biological Products - therapeutic use Biology and Life Sciences Blood glucose Cardiovascular disease Cholesterol Clinical trials Complementary Therapies Creatine Creatine kinase Creatinine Diabetes Dietary supplements Dyslipidemia Dyslipidemias - blood Dyslipidemias - drug therapy Heart Herbal medicine High density lipoprotein Hospitals Humans Lipids Lipids - blood Liver Function Tests Low density lipoprotein Low density lipoproteins Medicine and Health Sciences Meta-analysis Metabolic disorders Monascus purpureus Mortality Oryza Patients Physical Sciences Preventive medicine Publication Bias Randomization Randomized Controlled Trials as Topic Research and Analysis Methods Rice Ryanodine receptors Side effects Statins Studies Transaminase Treatment Outcome Triglycerides Vasoactive intestinal peptide Weapons of mass destruction Yeast |
| title | A meta-analysis of red yeast rice: an effective and relatively safe alternative approach for dyslipidemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T17%3A53%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20meta-analysis%20of%20red%20yeast%20rice:%20an%20effective%20and%20relatively%20safe%20alternative%20approach%20for%20dyslipidemia&rft.jtitle=PloS%20one&rft.au=Li,%20Yinhua&rft.date=2014-06-04&rft.volume=9&rft.issue=6&rft.spage=e98611&rft.pages=e98611-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0098611&rft_dat=%3Cgale_plos_%3EA416975477%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1532654550&rft_id=info:pmid/24897342&rft_galeid=A416975477&rft_doaj_id=oai_doaj_org_article_7806c0480add4e0388a54b30fe11f455&rfr_iscdi=true |