A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants

Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing agents trigger necrosis and proteolysis of in...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e95032-e95032
Hauptverfasser:	Brojatsch, Jürgen, Lima, Heriberto, Kar, Alak K, Jacobson, Lee S, Muehlbauer, Stefan M, Chandran, Kartik, Diaz-Griffero, Felipe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adjuvants Adjuvants, Pharmaceutic - pharmacology Aldehydes Aldehydes - pharmacology Alum Aluminum sulfate Animals Antigens, Bacterial - pharmacology Apoptosis Bacterial Toxins - pharmacology Biochemistry Biology and Life Sciences Cathepsin B Cathepsin B - antagonists & inhibitors Cathepsin B - metabolism Cathepsin C - antagonists & inhibitors Cathepsin C - metabolism Cathepsins Cell cycle Cell death Cytotoxicity Dipeptides - pharmacology Dipeptidyl-peptidase I Emergency medical care Gangrene Immune response Immune system Immunology Inducers Inflammation Inflammation - metabolism Inflammation - pathology Inhibitors Leupeptins - pharmacology Lysosomes - drug effects Lysosomes - metabolism Lysosomes - ultrastructure Medicine Medicine and Health Sciences Mice, Inbred BALB C Mice, Inbred C57BL Mortality Necrosis Peptides - pharmacology Protease inhibitors Proteasome inhibitors Proteasome Inhibitors - pharmacology Proteins Proteolysis Proteolysis - drug effects Research and Analysis Methods Rodents Rupture Rupturing Toxicity
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