Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus
To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D), which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE). Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong...
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| Veröffentlicht in: | PloS one 2014-06, Vol.9 (6), p.e98883-e98883 |
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| creator | Wang, Su-li Wu, Bin Zhu, Li-an Leng, Lin Bucala, Richard Lu, Liang-jing |
| description | To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D), which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE).
Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL), LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI), and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects.
240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44-0.7) apart from intimate relationships (r = 0.25) and body image (r = 0.18). There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = -0.589) and SDI (r = -0.509). When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631-0.812). EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI). There was no floor effect in EQ-5D but the ceiling effect remains strong (34%).
Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice. |
| doi_str_mv | 10.1371/journal.pone.0098883 |
| format | Article |
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Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL), LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI), and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects.
240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44-0.7) apart from intimate relationships (r = 0.25) and body image (r = 0.18). There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = -0.589) and SDI (r = -0.509). When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631-0.812). EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI). There was no floor effect in EQ-5D but the ceiling effect remains strong (34%).
Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098883</identifier><identifier>PMID: 24892282</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Arthritis ; Autoimmune diseases ; Biology and Life Sciences ; Body image ; Care and treatment ; China - epidemiology ; Chronic conditions ; Consent ; Correlation ; Criteria ; Cross-Sectional Studies ; Damage assessment ; Disease ; Equivalence ; FDA approval ; Female ; Hospitals ; Humans ; Lupus ; Lupus Erythematosus, Systemic - epidemiology ; Male ; Medical schools ; Medicine ; Medicine and Health Sciences ; Pain ; Patients ; Public Health Surveillance ; Quality of Life ; Quality-Adjusted Life Years ; Research and Analysis Methods ; Rheumatology ; Systematic review ; Systemic lupus erythematosus ; Validity ; Valuation ; Young Adult</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e98883-e98883</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Wang et al 2014 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4f0e2d79a02ed01ea54de6baa27294f1a09930abc8a052c65eaa027f98d9f0b83</citedby><cites>FETCH-LOGICAL-c692t-4f0e2d79a02ed01ea54de6baa27294f1a09930abc8a052c65eaa027f98d9f0b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043925/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043925/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24892282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Su-li</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Zhu, Li-an</creatorcontrib><creatorcontrib>Leng, Lin</creatorcontrib><creatorcontrib>Bucala, Richard</creatorcontrib><creatorcontrib>Lu, Liang-jing</creatorcontrib><title>Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D), which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE).
Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL), LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI), and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects.
240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44-0.7) apart from intimate relationships (r = 0.25) and body image (r = 0.18). There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = -0.589) and SDI (r = -0.509). When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631-0.812). EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI). There was no floor effect in EQ-5D but the ceiling effect remains strong (34%).
Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice.</description><subject>Adult</subject><subject>Arthritis</subject><subject>Autoimmune diseases</subject><subject>Biology and Life Sciences</subject><subject>Body image</subject><subject>Care and treatment</subject><subject>China - epidemiology</subject><subject>Chronic conditions</subject><subject>Consent</subject><subject>Correlation</subject><subject>Criteria</subject><subject>Cross-Sectional Studies</subject><subject>Damage assessment</subject><subject>Disease</subject><subject>Equivalence</subject><subject>FDA approval</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Pain</subject><subject>Patients</subject><subject>Public Health Surveillance</subject><subject>Quality of Life</subject><subject>Quality-Adjusted Life Years</subject><subject>Research and Analysis Methods</subject><subject>Rheumatology</subject><subject>Systematic review</subject><subject>Systemic lupus erythematosus</subject><subject>Validity</subject><subject>Valuation</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk19v0zAUxSMEYqPwDRBYQkLw0OLYTmq_IE1lQKVJE39frRvHbj25cbGdQb897ppNDdoDykMS53eOc4_vLYrnJZ6VdF6-u_J96MDNtr7TM4wF55w-KE5LQcm0Jpg-PHo-KZ7EeIVxRXldPy5OCOOCEE5OC1j4LqbQq4Sga5EKNulgfYeuwdnWph3yBqW1Rud98OiLd9PqA7Id2kKyuksR_bZpjeIuJr2xCrl-20ekwy5LNpB87OPT4pEBF_Wz4T4pfnw8_774PL24_LRcnF1MVS1ImjKDNWnnAjDRLS41VKzVdQNA5kQwUwIWgmJoFAdcEVVXGjI6N4K3wuCG00nx8uC7dT7KIZ0oy4qW-2wYy8TyQLQeruQ22A2EnfRg5c2CDysJIVnltGStgZqDKk1Ts6bCnDclYfld06YxtMle74fd-majW5WzCOBGpuMvnV3Llb-WDDMqSJUN3gwGwf_qdUxyY6PSzkGnfX_z37nums5pRl_9g95f3UCtIBdgO-PzvmpvKs9YWYuai9wPk2J2D5Wvdn9-uZWMzesjwduRIDNJ_0kr6GOUy29f_5-9_DlmXx-xaw0uraN3fcrNF8cgO4Aq-BiDNnchl1juJ-E2DbmfBDlMQpa9OD6gO9Ft69O_w7cFPg</recordid><startdate>20140603</startdate><enddate>20140603</enddate><creator>Wang, Su-li</creator><creator>Wu, Bin</creator><creator>Zhu, Li-an</creator><creator>Leng, Lin</creator><creator>Bucala, Richard</creator><creator>Lu, Liang-jing</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140603</creationdate><title>Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus</title><author>Wang, Su-li ; Wu, Bin ; Zhu, Li-an ; Leng, Lin ; Bucala, Richard ; Lu, Liang-jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4f0e2d79a02ed01ea54de6baa27294f1a09930abc8a052c65eaa027f98d9f0b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Biology and Life Sciences</topic><topic>Body image</topic><topic>Care and treatment</topic><topic>China - epidemiology</topic><topic>Chronic conditions</topic><topic>Consent</topic><topic>Correlation</topic><topic>Criteria</topic><topic>Cross-Sectional Studies</topic><topic>Damage assessment</topic><topic>Disease</topic><topic>Equivalence</topic><topic>FDA approval</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Pain</topic><topic>Patients</topic><topic>Public Health Surveillance</topic><topic>Quality of Life</topic><topic>Quality-Adjusted Life Years</topic><topic>Research and Analysis Methods</topic><topic>Rheumatology</topic><topic>Systematic review</topic><topic>Systemic lupus erythematosus</topic><topic>Validity</topic><topic>Valuation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Su-li</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Zhu, Li-an</creatorcontrib><creatorcontrib>Leng, Lin</creatorcontrib><creatorcontrib>Bucala, Richard</creatorcontrib><creatorcontrib>Lu, Liang-jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Su-li</au><au>Wu, Bin</au><au>Zhu, Li-an</au><au>Leng, Lin</au><au>Bucala, Richard</au><au>Lu, Liang-jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-06-03</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e98883</spage><epage>e98883</epage><pages>e98883-e98883</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D), which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE).
Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL), LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI), and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects.
240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44-0.7) apart from intimate relationships (r = 0.25) and body image (r = 0.18). There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = -0.589) and SDI (r = -0.509). When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631-0.812). EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI). There was no floor effect in EQ-5D but the ceiling effect remains strong (34%).
Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24892282</pmid><doi>10.1371/journal.pone.0098883</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Arthritis Autoimmune diseases Biology and Life Sciences Body image Care and treatment China - epidemiology Chronic conditions Consent Correlation Criteria Cross-Sectional Studies Damage assessment Disease Equivalence FDA approval Female Hospitals Humans Lupus Lupus Erythematosus, Systemic - epidemiology Male Medical schools Medicine Medicine and Health Sciences Pain Patients Public Health Surveillance Quality of Life Quality-Adjusted Life Years Research and Analysis Methods Rheumatology Systematic review Systemic lupus erythematosus Validity Valuation Young Adult |
| title | Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus |
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