Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma

We sought to identify a secreted biomarker for β-catenin activation commonly seen in hepatocellular carcinoma (HCC). By examination of our previously published genearray of hepatocyte-specific β-catenin knockout (KO) livers, we identified secreted factors whose expression may be β-catenin-dependent....

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e98817-e98817
Hauptverfasser:	Okabe, Hirohisa, Delgado, Evan, Lee, Jung Min, Yang, Jing, Kinoshita, Hiroki, Hayashi, Hiromitsu, Tsung, Allan, Behari, Jaideep, Beppu, Toru, Baba, Hideo, Monga, Satdarshan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals beta Catenin - genetics beta Catenin - metabolism Bioindicators Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Comparative analysis Hepatocellular carcinoma Humans Inflammation Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kinases Leukocytes Life sciences Liver Liver cancer Liver cirrhosis Liver diseases Liver Neoplasms - genetics Liver Neoplasms - metabolism Medical research Medicine and Health Sciences Mice Mice, Knockout Mutation Pathogenesis Pathology Patients Proteins Rodents Secretion Serum levels Surgery Transplants & implants Tumors β-Catenin
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