Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice
Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care. Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Ox...
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| description | Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care. Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Oxt knockout (Oxt -/-) mice, forebrain conditional Oxtr knockout (Oxtr FB/FB) mice, and total body Oxtr knockout (Oxtr -/-) mice. Since Oxtr -/- mice are unable to lactate, maternal behavior has only been examined in virgin females, or in dams within a few hours of parturition, and there have been no studies that have examined their anxiety-like and depression-like behavior following parturition. To improve our understanding of how the absence of Oxt signaling affects maternal behavior, mood and anxiety, we designed a study using Oxtr -/- mice that separated nursing behavior from other aspects of maternal care, such as licking and grooming by thelectomizing (i.e. removing the nipples) of Oxtr +/+ mice and sham-thelectomizing Oxtr -/- mice, and pairing both genotypes with a wet nurse. We then measured pup abandonment, maternal behavior, and postpartum anxiety-like and depression-like behaviors. We hypothesized that genetic disruption of the Oxtr would impact maternal care, mood and anxiety. Specifically, we predicted that Oxtr -/- dams would have impaired maternal care and increased anxiety-like and depression-like behaviors in the postpartum period. We found that Oxtr -/- dams had significantly higher levels of pup abandonment compared to controls, which is consistent with previous work in Oxtr FB/FB mice. Interestingly, Oxtr -/- dams that initiated maternal care did not differ from wildtype controls in measures of maternal behavior. We also did not find any evidence of altered anxiety-like or depressive-like behavior in the postpartum period of Oxtr -/- dams. Thus, our data suggest that Oxt lowers the threshold for the initiation of maternal behavior. |
| doi_str_mv | 10.1371/journal.pone.0098839 |
| format | Article |
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Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Oxt knockout (Oxt -/-) mice, forebrain conditional Oxtr knockout (Oxtr FB/FB) mice, and total body Oxtr knockout (Oxtr -/-) mice. Since Oxtr -/- mice are unable to lactate, maternal behavior has only been examined in virgin females, or in dams within a few hours of parturition, and there have been no studies that have examined their anxiety-like and depression-like behavior following parturition. To improve our understanding of how the absence of Oxt signaling affects maternal behavior, mood and anxiety, we designed a study using Oxtr -/- mice that separated nursing behavior from other aspects of maternal care, such as licking and grooming by thelectomizing (i.e. removing the nipples) of Oxtr +/+ mice and sham-thelectomizing Oxtr -/- mice, and pairing both genotypes with a wet nurse. We then measured pup abandonment, maternal behavior, and postpartum anxiety-like and depression-like behaviors. We hypothesized that genetic disruption of the Oxtr would impact maternal care, mood and anxiety. Specifically, we predicted that Oxtr -/- dams would have impaired maternal care and increased anxiety-like and depression-like behaviors in the postpartum period. We found that Oxtr -/- dams had significantly higher levels of pup abandonment compared to controls, which is consistent with previous work in Oxtr FB/FB mice. Interestingly, Oxtr -/- dams that initiated maternal care did not differ from wildtype controls in measures of maternal behavior. We also did not find any evidence of altered anxiety-like or depressive-like behavior in the postpartum period of Oxtr -/- dams. Thus, our data suggest that Oxt lowers the threshold for the initiation of maternal behavior.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098839</identifier><identifier>PMID: 24892749</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abandonment ; Analysis ; Animal behavior ; Animal models ; Animals ; Anxiety ; Anxiety - genetics ; Anxiety - physiopathology ; Behavior ; Behavior, Animal - physiology ; Biology and Life Sciences ; Dams ; Depression (Mood disorder) ; Female ; Females ; Forebrain ; Gene expression ; Genotypes ; Grooming ; Laboratories ; Lactic acid ; Maternal behavior ; Maternal Behavior - physiology ; Medicine and Health Sciences ; Mental depression ; Mice ; Mice, Knockout ; Mood ; Neuropeptides ; Nipples ; Nurses ; Nursing ; Oxytocin ; Parturition ; Physiological aspects ; Pituitary hormones ; Postpartum ; Postpartum depression ; Postpartum period ; Receptors, Oxytocin - deficiency ; Receptors, Oxytocin - genetics ; Rodents ; Signaling ; Studies</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e98839-e98839</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Rich et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Rich et al 2014 Rich et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-507bd04a9005bf96fd026047a552444ff78454a1e67dc7e44cc3ceae738e62cf3</citedby><cites>FETCH-LOGICAL-c758t-507bd04a9005bf96fd026047a552444ff78454a1e67dc7e44cc3ceae738e62cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044031/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044031/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24892749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schmidt, Ulrike</contributor><creatorcontrib>Rich, Megan E</creatorcontrib><creatorcontrib>deCárdenas, Emily J</creatorcontrib><creatorcontrib>Lee, Heon-Jin</creatorcontrib><creatorcontrib>Caldwell, Heather K</creatorcontrib><title>Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care. Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Oxt knockout (Oxt -/-) mice, forebrain conditional Oxtr knockout (Oxtr FB/FB) mice, and total body Oxtr knockout (Oxtr -/-) mice. Since Oxtr -/- mice are unable to lactate, maternal behavior has only been examined in virgin females, or in dams within a few hours of parturition, and there have been no studies that have examined their anxiety-like and depression-like behavior following parturition. To improve our understanding of how the absence of Oxt signaling affects maternal behavior, mood and anxiety, we designed a study using Oxtr -/- mice that separated nursing behavior from other aspects of maternal care, such as licking and grooming by thelectomizing (i.e. removing the nipples) of Oxtr +/+ mice and sham-thelectomizing Oxtr -/- mice, and pairing both genotypes with a wet nurse. We then measured pup abandonment, maternal behavior, and postpartum anxiety-like and depression-like behaviors. We hypothesized that genetic disruption of the Oxtr would impact maternal care, mood and anxiety. Specifically, we predicted that Oxtr -/- dams would have impaired maternal care and increased anxiety-like and depression-like behaviors in the postpartum period. We found that Oxtr -/- dams had significantly higher levels of pup abandonment compared to controls, which is consistent with previous work in Oxtr FB/FB mice. Interestingly, Oxtr -/- dams that initiated maternal care did not differ from wildtype controls in measures of maternal behavior. We also did not find any evidence of altered anxiety-like or depressive-like behavior in the postpartum period of Oxtr -/- dams. Thus, our data suggest that Oxt lowers the threshold for the initiation of maternal behavior.</description><subject>Abandonment</subject><subject>Analysis</subject><subject>Animal behavior</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety - physiopathology</subject><subject>Behavior</subject><subject>Behavior, Animal - physiology</subject><subject>Biology and Life Sciences</subject><subject>Dams</subject><subject>Depression (Mood disorder)</subject><subject>Female</subject><subject>Females</subject><subject>Forebrain</subject><subject>Gene expression</subject><subject>Genotypes</subject><subject>Grooming</subject><subject>Laboratories</subject><subject>Lactic acid</subject><subject>Maternal behavior</subject><subject>Maternal Behavior - physiology</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mood</subject><subject>Neuropeptides</subject><subject>Nipples</subject><subject>Nurses</subject><subject>Nursing</subject><subject>Oxytocin</subject><subject>Parturition</subject><subject>Physiological aspects</subject><subject>Pituitary hormones</subject><subject>Postpartum</subject><subject>Postpartum depression</subject><subject>Postpartum period</subject><subject>Receptors, Oxytocin - deficiency</subject><subject>Receptors, Oxytocin - genetics</subject><subject>Rodents</subject><subject>Signaling</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl9v0zAUxSMEYmPwDRBUQkLw0GLHTmy_IE0TfypNmgSMV-vWuWndJXGxnWn79jhrNjVoDygPtm5-91z7-GTZa0oWlAn6aet630Gz2LkOF4QoKZl6kh1TxfJ5mRP29GB_lL0IYUtIwWRZPs-Oci5VLrg6zi6X7Q6sb7GLYWa7WdxgWmy0EK3rZq6etRBxGDRb4QaurfMD5m5uozNp49HgLqbiVefMlevjrLUGX2bPamgCvhrXk-zy65dfZ9_n5xfflmen53MjChnnBRGrinBQ6WSrWpV1RfKScAFFkXPO61pIXnCgWIrKCOTcGGYQUDCJZW5qdpK93evuGhf06EjQtGBUSSFKkYjlnqgcbPXO2xb8rXZg9V3B-bUGH61pUAOsCmAoq0owzggqVShDZSXzSiXf8qT1eZzWr1qsTPLMQzMRnf7p7Eav3bXmhHPCaBL4MAp496fHEHVrg8GmgQ5df3fuXHFB6IC--wd9_HYjtYZ0AdvVLs01g6g-5bRUpVRCJWrxCJW-CtNjpfjUNtUnDR8nDYmJeBPX0Ieglz9__D978XvKvj9gNwhN3ATX9EPUwhTke9B4F4LH-sFkSvSQ_ns39JB-PaY_tb05fKCHpvu4s785FP_k</recordid><startdate>20140603</startdate><enddate>20140603</enddate><creator>Rich, Megan E</creator><creator>deCárdenas, Emily J</creator><creator>Lee, Heon-Jin</creator><creator>Caldwell, Heather K</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140603</creationdate><title>Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice</title><author>Rich, Megan E ; deCárdenas, Emily J ; Lee, Heon-Jin ; Caldwell, Heather K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-507bd04a9005bf96fd026047a552444ff78454a1e67dc7e44cc3ceae738e62cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abandonment</topic><topic>Analysis</topic><topic>Animal behavior</topic><topic>Animal models</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rich, Megan E</au><au>deCárdenas, Emily J</au><au>Lee, Heon-Jin</au><au>Caldwell, Heather K</au><au>Schmidt, Ulrike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-06-03</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e98839</spage><epage>e98839</epage><pages>e98839-e98839</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Oxytocin (Oxt) acting through its single receptor subtype, the Oxtr, is important for the coordination of physiology and behavior associated with parturition and maternal care. Knockout mouse models have been helpful in exploring the contributions of Oxt to maternal behavior, including total body Oxt knockout (Oxt -/-) mice, forebrain conditional Oxtr knockout (Oxtr FB/FB) mice, and total body Oxtr knockout (Oxtr -/-) mice. Since Oxtr -/- mice are unable to lactate, maternal behavior has only been examined in virgin females, or in dams within a few hours of parturition, and there have been no studies that have examined their anxiety-like and depression-like behavior following parturition. To improve our understanding of how the absence of Oxt signaling affects maternal behavior, mood and anxiety, we designed a study using Oxtr -/- mice that separated nursing behavior from other aspects of maternal care, such as licking and grooming by thelectomizing (i.e. removing the nipples) of Oxtr +/+ mice and sham-thelectomizing Oxtr -/- mice, and pairing both genotypes with a wet nurse. We then measured pup abandonment, maternal behavior, and postpartum anxiety-like and depression-like behaviors. We hypothesized that genetic disruption of the Oxtr would impact maternal care, mood and anxiety. Specifically, we predicted that Oxtr -/- dams would have impaired maternal care and increased anxiety-like and depression-like behaviors in the postpartum period. We found that Oxtr -/- dams had significantly higher levels of pup abandonment compared to controls, which is consistent with previous work in Oxtr FB/FB mice. Interestingly, Oxtr -/- dams that initiated maternal care did not differ from wildtype controls in measures of maternal behavior. We also did not find any evidence of altered anxiety-like or depressive-like behavior in the postpartum period of Oxtr -/- dams. Thus, our data suggest that Oxt lowers the threshold for the initiation of maternal behavior.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24892749</pmid><doi>10.1371/journal.pone.0098839</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abandonment Analysis Animal behavior Animal models Animals Anxiety Anxiety - genetics Anxiety - physiopathology Behavior Behavior, Animal - physiology Biology and Life Sciences Dams Depression (Mood disorder) Female Females Forebrain Gene expression Genotypes Grooming Laboratories Lactic acid Maternal behavior Maternal Behavior - physiology Medicine and Health Sciences Mental depression Mice Mice, Knockout Mood Neuropeptides Nipples Nurses Nursing Oxytocin Parturition Physiological aspects Pituitary hormones Postpartum Postpartum depression Postpartum period Receptors, Oxytocin - deficiency Receptors, Oxytocin - genetics Rodents Signaling Studies |
| title | Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T20%3A32%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impairments%20in%20the%20initiation%20of%20maternal%20behavior%20in%20oxytocin%20receptor%20knockout%20mice&rft.jtitle=PloS%20one&rft.au=Rich,%20Megan%20E&rft.date=2014-06-03&rft.volume=9&rft.issue=6&rft.spage=e98839&rft.epage=e98839&rft.pages=e98839-e98839&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0098839&rft_dat=%3Cgale_plos_%3EA416968979%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1531987767&rft_id=info:pmid/24892749&rft_galeid=A416968979&rft_doaj_id=oai_doaj_org_article_aab5a3e8dd73430e9959c18d82d93862&rfr_iscdi=true |