Induction of neutralizing antibody response against four dengue viruses in mice by intramuscular electroporation of tetravalent DNA vaccines

DNA vaccine against dengue is an interesting strategy for a prime/boost approach. This study evaluated neutralizing antibody (NAb) induction of a dengue tetravalent DNA (TDNA) vaccine candidate administered by intramuscular-electroporation (IM-EP) and the benefit of homologous TDNA boosting in mice....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e92643-e92643
Hauptverfasser:	Prompetchara, Eakachai, Ketloy, Chutitorn, Keelapang, Poonsook, Sittisombut, Nopporn, Ruxrungtham, Kiat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - immunology Antibody Formation - immunology Antibody response Biology and Life Sciences Cell culture Cell Line Cloning Dengue Dengue - immunology Dengue - prevention & control Dengue - virology Dengue fever Dengue Vaccines - immunology Dengue Virus - immunology Deoxyribonucleic acid DNA DNA vaccines Electroporation Genetic research Homology Humans Immunization Immunization, Secondary Infections Influenza Injection Injections, Intramuscular Kinetics Laboratory animals Measles Medicine Medicine and Health Sciences Mice Mice, Inbred ICR Military personnel Neutralization Neutralizing Primates Protein expression Proteins Research and Analysis Methods Serotypes Vaccines Vaccines, DNA - immunology Vector-borne diseases Viral diseases Viral Proteins - metabolism Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!