Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression

Most cancer patients die with metastatic disease, thus, good models that recapitulate the natural process of metastasis including a dormancy period with micrometastatic cells would be beneficial in developing treatment strategies. Herein we report a model of natural metastasis that balances time to...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98624-e98624
Hauptverfasser:	Bailey-Downs, Lora C, Thorpe, Jessica E, Disch, Bryan C, Bastian, Anja, Hauser, Paul J, Farasyn, Taleah, Berry, William L, Hurst, Robert E, Ihnat, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal models Animals Anthracyclines Biology and Life Sciences Brain Brain cancer Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer therapies Cell Line, Tumor Chemical properties Chemotherapy Disease Progression Dormancy Doxorubicin Doxorubicin - pharmacology Drug development Female Immunosuppressive agents Implantation Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - secondary Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Medicine Medicine and Health Sciences Metastases Metastasis Mice Mice, Inbred BALB C Neoplasm Metastasis - drug therapy Neoplasm Metastasis - pathology Neoplasm Micrometastasis - drug therapy Neoplasm Micrometastasis - pathology Pharmaceutical sciences Pharmacy Research and Analysis Methods Titration Tumorigenesis Tumors Urology
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