Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblasts

Autophagy is an intrinsic host defense system that recognizes and eliminates invading bacterial pathogens. We have identified microtubule-associated protein 1 light chain 3 (LC3), a hallmark of autophagy, as a binding partner of phospholipase C-related catalytically inactive protein (PRIP) that was...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98285-e98285
Hauptverfasser:	Harada-Hada, Kae, Harada, Kana, Kato, Fuminori, Hisatsune, Junzo, Tanida, Isei, Ogawa, Michinaga, Asano, Satoshi, Sugai, Motoyuki, Hirata, Masato, Kanematsu, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Adapter proteins Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Autophagy Bacteriology Biochemistry Biology and Life Sciences Biosynthesis Cell death Cells, Cultured Embryo fibroblasts Embryos Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Health aspects Health sciences Image analysis Image processing Immune system Immunity, Innate Infection Infectious diseases Innate immunity Kinases Lysosomes Mammals Mice Mice, Knockout Microtubule-associated protein 1 Microtubule-Associated Proteins - metabolism Pathogens Phagocytes Phagocytosis Phagosomes Phagosomes - metabolism Phagosomes - microbiology Pharmacology Phosphatase Phospholipase Phospholipase C Phospholipases Plasmids Protein binding Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - physiology Staphylococcus aureus infections Staphylococcus infections Vacuoles
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