CBX7 modulates the expression of genes critical for cancer progression

We have previously shown that the expression of CBX7 is drastically decreased in several human carcinomas and that its expression progressively decreases with the appearance of a highly malignant phenotype. The aim of our study has been to investigate the mechanism by which the loss of CBX7 expressi...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98295
Hauptverfasser:	Pallante, Pierlorenzo, Sepe, Romina, Federico, Antonella, Forzati, Floriana, Bianco, Mimma, Fusco, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biology and life sciences Cancer Cancer genetics Carcinogenesis Carcinogens Cell cycle Cell Line, Tumor Colorectal cancer Correlation Deregulation Development and progression Disease Progression EGR-1 protein FosB protein Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockout Techniques Gene regulation Genes Genes, Neoplasm Genetic aspects Genotype & phenotype HEK293 Cells Humans Hybridization Lung cancer Lung carcinoma Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical prognosis Medicine and Health Sciences Metastasis Oligonucleotide Array Sequence Analysis Ovarian cancer Phenotypes Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Polymerase chain reaction Promoter Regions, Genetic Prostate Proteins Rats Restoration Rodents Thyroid Thyroid cancer Thyroid carcinoma Thyroid diseases Thyroid gland Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Tissues Transcription
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