Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers
It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed...
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| creator | Tho, Nguyen Van Trang, Le Thi Huyen Murakami, Yoshitaka Ogawa, Emiko Ryujin, Yasushi Kanda, Rie Nakagawa, Hiroaki Goto, Kenichi Fukunaga, Kentaro Higami, Yuichi Seto, Ruriko Nagao, Taishi Oguma, Tetsuya Yamaguchi, Masafumi Lan, Le Thi Tuyet Nakano, Yasutaka |
| description | It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed tomography (CT) analysis. We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.
Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensional CT analysis software. √Aaw at Pi10 of each lung lobe was estimated from all measurable bronchial segments of that lobe.
Using a mixed-effects model, √Aaw at Pi10 differed significantly among the five lung lobes (R(2) = 0.78, P |
| doi_str_mv | 10.1371/journal.pone.0098335 |
| format | Article |
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Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensional CT analysis software. √Aaw at Pi10 of each lung lobe was estimated from all measurable bronchial segments of that lobe.
Using a mixed-effects model, √Aaw at Pi10 differed significantly among the five lung lobes (R(2) = 0.78, P<0.0001). The Bland-Altman plots show that √Aaw at Pi10 derived from the right or left upper lobe had a high level of agreement with that derived from the whole lungs, while √Aaw at Pi10 derived from the right or left lower lobe did not.
In male smokers, CT-derived airway wall area differs among the five lung lobes, and airway wall area derived from the right or left upper lobe is representative of the whole lungs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098335</identifier><identifier>PMID: 24865661</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asthma ; Biology and Life Sciences ; Bronchi - pathology ; Bronchi - physiopathology ; CAT scans ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Computation ; Computed tomography ; Dimensional analysis ; Emphysema ; Four-Dimensional Computed Tomography - methods ; Humans ; Level (quantity) ; Levels ; Lobes ; Lung diseases ; Lungs ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Obstructive lung disease ; Patients ; Pulmonary Disease, Chronic Obstructive - chemically induced ; Pulmonary Disease, Chronic Obstructive - pathology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary functions ; Respiratory function ; Respiratory Function Tests - methods ; Respiratory tract ; Science ; Segments ; Smokers ; Smoking ; Smoking - adverse effects ; Studies ; Test procedures ; Values ; X rays</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e98335</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Tho et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Tho et al 2014 Tho et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c787t-d6176bd316e204a971a5744a4e8e7608bebff85a1f06612ed3db4ad34faf3d523</citedby><cites>FETCH-LOGICAL-c787t-d6176bd316e204a971a5744a4e8e7608bebff85a1f06612ed3db4ad34faf3d523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035347/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035347/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23847,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24865661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Munns, Suzanne</contributor><creatorcontrib>Tho, Nguyen Van</creatorcontrib><creatorcontrib>Trang, Le Thi Huyen</creatorcontrib><creatorcontrib>Murakami, Yoshitaka</creatorcontrib><creatorcontrib>Ogawa, Emiko</creatorcontrib><creatorcontrib>Ryujin, Yasushi</creatorcontrib><creatorcontrib>Kanda, Rie</creatorcontrib><creatorcontrib>Nakagawa, Hiroaki</creatorcontrib><creatorcontrib>Goto, Kenichi</creatorcontrib><creatorcontrib>Fukunaga, Kentaro</creatorcontrib><creatorcontrib>Higami, Yuichi</creatorcontrib><creatorcontrib>Seto, Ruriko</creatorcontrib><creatorcontrib>Nagao, Taishi</creatorcontrib><creatorcontrib>Oguma, Tetsuya</creatorcontrib><creatorcontrib>Yamaguchi, Masafumi</creatorcontrib><creatorcontrib>Lan, Le Thi Tuyet</creatorcontrib><creatorcontrib>Nakano, Yasutaka</creatorcontrib><title>Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional computed tomography (CT) analysis. We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.
Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensional CT analysis software. √Aaw at Pi10 of each lung lobe was estimated from all measurable bronchial segments of that lobe.
Using a mixed-effects model, √Aaw at Pi10 differed significantly among the five lung lobes (R(2) = 0.78, P<0.0001). The Bland-Altman plots show that √Aaw at Pi10 derived from the right or left upper lobe had a high level of agreement with that derived from the whole lungs, while √Aaw at Pi10 derived from the right or left lower lobe did not.
In male smokers, CT-derived airway wall area differs among the five lung lobes, and airway wall area derived from the right or left upper lobe is representative of the whole lungs.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asthma</subject><subject>Biology and Life Sciences</subject><subject>Bronchi - pathology</subject><subject>Bronchi - physiopathology</subject><subject>CAT scans</subject><subject>Chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Dimensional analysis</subject><subject>Emphysema</subject><subject>Four-Dimensional Computed Tomography - methods</subject><subject>Humans</subject><subject>Level (quantity)</subject><subject>Levels</subject><subject>Lobes</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Obstructive lung disease</subject><subject>Patients</subject><subject>Pulmonary Disease, Chronic Obstructive - chemically induced</subject><subject>Pulmonary Disease, Chronic Obstructive - pathology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary functions</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests - methods</subject><subject>Respiratory tract</subject><subject>Science</subject><subject>Segments</subject><subject>Smokers</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Studies</subject><subject>Test procedures</subject><subject>Values</subject><subject>X rays</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluL2zAQhU1p6W7T_oPSCgqFPiSVLNmyXxbC0ktgYaG3VzG2RolS28pK9m7z76s03iWGForAMjPfnLEPJ0leMrpgXLL3Wzf4DprFznW4oLQsOM8eJees5Ok8Tyl_fPJ-ljwLYUtpxos8f5qcpaLIszxn58nN0vo72JM7aBoCHoFo9PYWNTHetYTPtW2xC9bFVaR27W7oY693rVt72G32BGJjH2wg2hqDPhBoXbcmzXB4uAoDsR1poUESWvczAs-TJwaagC_Ge5Z8__jh2-Xn-dX1p9Xl8mpey0L2c50zmVeasxxTKqCUDDIpBAgsUOa0qLAypsiAGRp_JEXNdSVAc2HAcJ2lfJa8PuruGhfU6FZQLEuLskh59GuWrI6EdrBVO29b8HvlwKo_BefXCnxv6wZVnTKAUvC4GQTTugItSlNRLI2UrIaodTFuG6oWdY1d76GZiE47nd2otbtVgvKMCxkF3owC3t0MGPp_fPJIraOjynbGRbG6taFWS8GkLHlRlpFa_IWKR2Nr65gXY2N9MvBuMhCZHn_1axhCUKuvX_6fvf4xZd-esBuEpt8E1wx9zFOYguII1t6F4NE8OMeoOsT93g11iLsa4x7HXp26_jB0n2_-G--F_Rw</recordid><startdate>20140527</startdate><enddate>20140527</enddate><creator>Tho, Nguyen Van</creator><creator>Trang, Le Thi Huyen</creator><creator>Murakami, Yoshitaka</creator><creator>Ogawa, Emiko</creator><creator>Ryujin, Yasushi</creator><creator>Kanda, Rie</creator><creator>Nakagawa, Hiroaki</creator><creator>Goto, Kenichi</creator><creator>Fukunaga, Kentaro</creator><creator>Higami, Yuichi</creator><creator>Seto, Ruriko</creator><creator>Nagao, Taishi</creator><creator>Oguma, Tetsuya</creator><creator>Yamaguchi, Masafumi</creator><creator>Lan, Le Thi Tuyet</creator><creator>Nakano, Yasutaka</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140527</creationdate><title>Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers</title><author>Tho, Nguyen Van ; Trang, Le Thi Huyen ; Murakami, Yoshitaka ; Ogawa, Emiko ; Ryujin, Yasushi ; Kanda, Rie ; Nakagawa, Hiroaki ; Goto, Kenichi ; Fukunaga, Kentaro ; Higami, Yuichi ; Seto, Ruriko ; Nagao, Taishi ; Oguma, Tetsuya ; Yamaguchi, Masafumi ; Lan, Le Thi Tuyet ; Nakano, Yasutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c787t-d6176bd316e204a971a5744a4e8e7608bebff85a1f06612ed3db4ad34faf3d523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asthma</topic><topic>Biology and Life Sciences</topic><topic>Bronchi - pathology</topic><topic>Bronchi - physiopathology</topic><topic>CAT scans</topic><topic>Chronic obstructive lung disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Dimensional analysis</topic><topic>Emphysema</topic><topic>Four-Dimensional Computed Tomography - methods</topic><topic>Humans</topic><topic>Level (quantity)</topic><topic>Levels</topic><topic>Lobes</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Obstructive lung disease</topic><topic>Patients</topic><topic>Pulmonary Disease, Chronic Obstructive - chemically induced</topic><topic>Pulmonary Disease, Chronic Obstructive - pathology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary functions</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests - 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We hypothesized that √Aaw at Pi10 differs among the five lung lobes and √Aaw at Pi10 derived from one certain lung lobe has a high level of agreement with that derived from the whole lungs in smokers.
Pulmonary function tests and chest volumetric CTs were performed in 157 male smokers (102 COPD, 55 non-COPD). All visible bronchial segments from the 3rd to 5th generations were segmented and measured using commercially available 3-dimensional CT analysis software. √Aaw at Pi10 of each lung lobe was estimated from all measurable bronchial segments of that lobe.
Using a mixed-effects model, √Aaw at Pi10 differed significantly among the five lung lobes (R(2) = 0.78, P<0.0001). The Bland-Altman plots show that √Aaw at Pi10 derived from the right or left upper lobe had a high level of agreement with that derived from the whole lungs, while √Aaw at Pi10 derived from the right or left lower lobe did not.
In male smokers, CT-derived airway wall area differs among the five lung lobes, and airway wall area derived from the right or left upper lobe is representative of the whole lungs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24865661</pmid><doi>10.1371/journal.pone.0098335</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1528982398 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Aged Aged, 80 and over Asthma Biology and Life Sciences Bronchi - pathology Bronchi - physiopathology CAT scans Chronic obstructive lung disease Chronic obstructive pulmonary disease Computation Computed tomography Dimensional analysis Emphysema Four-Dimensional Computed Tomography - methods Humans Level (quantity) Levels Lobes Lung diseases Lungs Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Obstructive lung disease Patients Pulmonary Disease, Chronic Obstructive - chemically induced Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary functions Respiratory function Respiratory Function Tests - methods Respiratory tract Science Segments Smokers Smoking Smoking - adverse effects Studies Test procedures Values X rays |
| title | Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A16%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Airway%20wall%20area%20derived%20from%203-dimensional%20computed%20tomography%20analysis%20differs%20among%20lung%20lobes%20in%20male%20smokers&rft.jtitle=PloS%20one&rft.au=Tho,%20Nguyen%20Van&rft.date=2014-05-27&rft.volume=9&rft.issue=5&rft.spage=e98335&rft.pages=e98335-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0098335&rft_dat=%3Cgale_plos_%3EA417793899%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1528982398&rft_id=info:pmid/24865661&rft_galeid=A417793899&rft_doaj_id=oai_doaj_org_article_c21aa943760a41ddbad49fb0e9f771ca&rfr_iscdi=true |