Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue
Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor...
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| description | Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks. |
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Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098156</identifier><identifier>PMID: 24858857</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activation ; Adult ; Apathy ; Basal ganglia ; Behavior ; Behavioral sciences ; Biology and Life Sciences ; Brain ; Caudate nucleus ; Caudate Nucleus - diagnostic imaging ; Caudate Nucleus - physiopathology ; Chronic fatigue syndrome ; Correlation analysis ; Cortex ; Cytokines ; Disease control ; Disease prevention ; Dopamine ; Family medical history ; Fatigue ; Fatigue Syndrome, Chronic - diagnostic imaging ; Fatigue Syndrome, Chronic - physiopathology ; Female ; Functional magnetic resonance imaging ; Gambling ; Ganglia ; Globus pallidus ; Globus Pallidus - diagnostic imaging ; Globus Pallidus - physiopathology ; Health aspects ; HIV ; Human immunodeficiency virus ; Humans ; Immune response ; Inflammation ; Interviews ; Laboratories ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medicine and Health Sciences ; Middle Aged ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Parkinson's disease ; Parkinsons disease ; Patients ; Psychiatry ; Psychomotor Performance ; Putamen ; Radiography ; Reinforcement ; Social Sciences ; Studies ; Thalamus ; Viral infections</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e98156-e98156</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 . This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ddecbcc9b134a8464dfbd3ddfe998ab08b277c5405aa4fa07877c6c883828e273</citedby><cites>FETCH-LOGICAL-c692t-ddecbcc9b134a8464dfbd3ddfe998ab08b277c5405aa4fa07877c6c883828e273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032274/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032274/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24858857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Andrew H</creatorcontrib><creatorcontrib>Jones, James F</creatorcontrib><creatorcontrib>Drake, Daniel F</creatorcontrib><creatorcontrib>Tian, Hao</creatorcontrib><creatorcontrib>Unger, Elizabeth R</creatorcontrib><creatorcontrib>Pagnoni, Giuseppe</creatorcontrib><title>Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks.</description><subject>Activation</subject><subject>Adult</subject><subject>Apathy</subject><subject>Basal ganglia</subject><subject>Behavior</subject><subject>Behavioral sciences</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Caudate nucleus</subject><subject>Caudate Nucleus - diagnostic imaging</subject><subject>Caudate Nucleus - physiopathology</subject><subject>Chronic fatigue syndrome</subject><subject>Correlation analysis</subject><subject>Cortex</subject><subject>Cytokines</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Dopamine</subject><subject>Family medical history</subject><subject>Fatigue</subject><subject>Fatigue Syndrome, Chronic - diagnostic imaging</subject><subject>Fatigue Syndrome, Chronic - physiopathology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Gambling</subject><subject>Ganglia</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - diagnostic imaging</subject><subject>Globus Pallidus - physiopathology</subject><subject>Health aspects</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Interviews</subject><subject>Laboratories</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Parkinson's disease</subject><subject>Parkinsons disease</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Psychomotor Performance</subject><subject>Putamen</subject><subject>Radiography</subject><subject>Reinforcement</subject><subject>Social Sciences</subject><subject>Studies</subject><subject>Thalamus</subject><subject>Viral 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basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue</title><author>Miller, Andrew H ; Jones, James F ; Drake, Daniel F ; Tian, Hao ; Unger, Elizabeth R ; Pagnoni, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ddecbcc9b134a8464dfbd3ddfe998ab08b277c5405aa4fa07877c6c883828e273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Activation</topic><topic>Adult</topic><topic>Apathy</topic><topic>Basal ganglia</topic><topic>Behavior</topic><topic>Behavioral sciences</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Caudate nucleus</topic><topic>Caudate Nucleus - diagnostic imaging</topic><topic>Caudate Nucleus - physiopathology</topic><topic>Chronic fatigue syndrome</topic><topic>Correlation analysis</topic><topic>Cortex</topic><topic>Cytokines</topic><topic>Disease control</topic><topic>Disease prevention</topic><topic>Dopamine</topic><topic>Family medical history</topic><topic>Fatigue</topic><topic>Fatigue Syndrome, Chronic - diagnostic imaging</topic><topic>Fatigue Syndrome, Chronic - physiopathology</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Gambling</topic><topic>Ganglia</topic><topic>Globus pallidus</topic><topic>Globus Pallidus - diagnostic imaging</topic><topic>Globus Pallidus - physiopathology</topic><topic>Health aspects</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune response</topic><topic>Inflammation</topic><topic>Interviews</topic><topic>Laboratories</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>NMR</topic><topic>Nuclear magnetic 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One</addtitle><date>2014-05-23</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e98156</spage><epage>e98156</epage><pages>e98156-e98156</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24858857</pmid><doi>10.1371/journal.pone.0098156</doi><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| subjects | Activation Adult Apathy Basal ganglia Behavior Behavioral sciences Biology and Life Sciences Brain Caudate nucleus Caudate Nucleus - diagnostic imaging Caudate Nucleus - physiopathology Chronic fatigue syndrome Correlation analysis Cortex Cytokines Disease control Disease prevention Dopamine Family medical history Fatigue Fatigue Syndrome, Chronic - diagnostic imaging Fatigue Syndrome, Chronic - physiopathology Female Functional magnetic resonance imaging Gambling Ganglia Globus pallidus Globus Pallidus - diagnostic imaging Globus Pallidus - physiopathology Health aspects HIV Human immunodeficiency virus Humans Immune response Inflammation Interviews Laboratories Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Medicine and Health Sciences Middle Aged Neurosciences NMR Nuclear magnetic resonance Parkinson's disease Parkinsons disease Patients Psychiatry Psychomotor Performance Putamen Radiography Reinforcement Social Sciences Studies Thalamus Viral infections |
| title | Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T09%3A37%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20basal%20ganglia%20activation%20in%20subjects%20with%20chronic%20fatigue%20syndrome:%20association%20with%20symptoms%20of%20fatigue&rft.jtitle=PloS%20one&rft.au=Miller,%20Andrew%20H&rft.date=2014-05-23&rft.volume=9&rft.issue=5&rft.spage=e98156&rft.epage=e98156&rft.pages=e98156-e98156&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0098156&rft_dat=%3Cgale_plos_%3EA418127547%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1528074840&rft_id=info:pmid/24858857&rft_galeid=A418127547&rft_doaj_id=oai_doaj_org_article_374df5be80d84084ab5b6744534806b8&rfr_iscdi=true |