Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency
The primary objectives of the present study are to determine the period of onset of ovarian insufficiency after surgery and to confirm potential risk factors for ovarian insufficiency after surgery for the removal of benign ovarian cysts. Data were obtained from 75 patients who underwent surgery for...
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| Veröffentlicht in: | PloS one 2014-05, Vol.9 (5), p.e98174-e98174 |
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| creator | Takae, Seido Kawamura, Kazuhiro Sato, Yorino Nishijima, Chie Yoshioka, Nobuhito Sugishita, Yodo Horage, Yuki Tanaka, Mamoru Ishizuka, Bunpei Suzuki, Nao |
| description | The primary objectives of the present study are to determine the period of onset of ovarian insufficiency after surgery and to confirm potential risk factors for ovarian insufficiency after surgery for the removal of benign ovarian cysts. Data were obtained from 75 patients who underwent surgery for benign ovarian cysts prior to the onset of ovarian insufficiency. Our analysis included 835 ovarian insufficiency patients who were referred to our institution from July 2003 to July 2013. Several epidemiological parameters of ovarian insufficiency after surgery (age at operation, period of onset of ovarian insufficiency, operation procedure, and pathological diagnosis) were investigated. Of the 835 patients who had ovarian insufficiency, 75 patients (9.0%) underwent ovarian surgery before the onset of ovarian insufficiency. Of those 75 patients, 66 patients (88.0%) underwent cystectomy. For the majority of the 75 patients the surgical indication was the presence of endometriotic cysts (57 patients; 76.0%). Twelve patients (16.0%) underwent multiple surgeries (all bilateral cystectomies). The mean age of the patients at the time of surgery was 27.8±5.5 years-old, and the mean period of onset of ovarian insufficiency was 5.8±3.8 years. In patients with cystectomy, the patient's age at the time of surgery and period of onset of ovarian insufficiency was well-correlated (coefficient of correlation; hemilateral endometriotic cystectomy: -0.64, bilateral endometriotic cystectomy: -0.61, and multiple endimetriotic cystectomy: -0.40). We found that cystectomy of endometriotic cysts is the potential risk factor for ovarian insufficiency after surgery, at times, the onset of ovarian insufficiency long after cystectomy. Therefore, it is important to monitor ovarian reserve for an extended period of time after ovarian surgery. It is particularly important to monitor ovarian reserve long-term for patients who wish to conceive in the future and to suggest a variety of infertility treatments appropriate for their ovarian reserve. |
| doi_str_mv | 10.1371/journal.pone.0098174 |
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Data were obtained from 75 patients who underwent surgery for benign ovarian cysts prior to the onset of ovarian insufficiency. Our analysis included 835 ovarian insufficiency patients who were referred to our institution from July 2003 to July 2013. Several epidemiological parameters of ovarian insufficiency after surgery (age at operation, period of onset of ovarian insufficiency, operation procedure, and pathological diagnosis) were investigated. Of the 835 patients who had ovarian insufficiency, 75 patients (9.0%) underwent ovarian surgery before the onset of ovarian insufficiency. Of those 75 patients, 66 patients (88.0%) underwent cystectomy. For the majority of the 75 patients the surgical indication was the presence of endometriotic cysts (57 patients; 76.0%). Twelve patients (16.0%) underwent multiple surgeries (all bilateral cystectomies). The mean age of the patients at the time of surgery was 27.8±5.5 years-old, and the mean period of onset of ovarian insufficiency was 5.8±3.8 years. In patients with cystectomy, the patient's age at the time of surgery and period of onset of ovarian insufficiency was well-correlated (coefficient of correlation; hemilateral endometriotic cystectomy: -0.64, bilateral endometriotic cystectomy: -0.61, and multiple endimetriotic cystectomy: -0.40). We found that cystectomy of endometriotic cysts is the potential risk factor for ovarian insufficiency after surgery, at times, the onset of ovarian insufficiency long after cystectomy. Therefore, it is important to monitor ovarian reserve for an extended period of time after ovarian surgery. It is particularly important to monitor ovarian reserve long-term for patients who wish to conceive in the future and to suggest a variety of infertility treatments appropriate for their ovarian reserve.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0098174</identifier><identifier>PMID: 24858999</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Amenorrhea ; Analysis ; Benign ; Biology and Life Sciences ; Cystectomy - adverse effects ; Cysts ; Epidemiology ; Female ; Fertility ; Gynecology ; Humans ; Infertility ; Laparoscopy ; Male ; Medical research ; Medicine ; Medicine and Health Sciences ; Menstruation ; Obstetrics ; Patients ; Postoperative Complications - epidemiology ; Primary Ovarian Insufficiency - epidemiology ; Primary Ovarian Insufficiency - etiology ; Reproductive health ; Retrospective Studies ; Risk analysis ; Risk factors ; Studies ; Surgery ; Surgical techniques</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e98174-e98174</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Takae et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Takae et al 2014 Takae et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4fb065712850212afd5c972793cdd3254d7d6969a1a7cde6a0b98615a65ddf0c3</citedby><cites>FETCH-LOGICAL-c692t-4fb065712850212afd5c972793cdd3254d7d6969a1a7cde6a0b98615a65ddf0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032277/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032277/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24858999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lo, Anthony W.I.</contributor><creatorcontrib>Takae, Seido</creatorcontrib><creatorcontrib>Kawamura, Kazuhiro</creatorcontrib><creatorcontrib>Sato, Yorino</creatorcontrib><creatorcontrib>Nishijima, Chie</creatorcontrib><creatorcontrib>Yoshioka, Nobuhito</creatorcontrib><creatorcontrib>Sugishita, Yodo</creatorcontrib><creatorcontrib>Horage, Yuki</creatorcontrib><creatorcontrib>Tanaka, Mamoru</creatorcontrib><creatorcontrib>Ishizuka, Bunpei</creatorcontrib><creatorcontrib>Suzuki, Nao</creatorcontrib><title>Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The primary objectives of the present study are to determine the period of onset of ovarian insufficiency after surgery and to confirm potential risk factors for ovarian insufficiency after surgery for the removal of benign ovarian cysts. 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The mean age of the patients at the time of surgery was 27.8±5.5 years-old, and the mean period of onset of ovarian insufficiency was 5.8±3.8 years. In patients with cystectomy, the patient's age at the time of surgery and period of onset of ovarian insufficiency was well-correlated (coefficient of correlation; hemilateral endometriotic cystectomy: -0.64, bilateral endometriotic cystectomy: -0.61, and multiple endimetriotic cystectomy: -0.40). We found that cystectomy of endometriotic cysts is the potential risk factor for ovarian insufficiency after surgery, at times, the onset of ovarian insufficiency long after cystectomy. Therefore, it is important to monitor ovarian reserve for an extended period of time after ovarian surgery. It is particularly important to monitor ovarian reserve long-term for patients who wish to conceive in the future and to suggest a variety of infertility treatments appropriate for their ovarian reserve.</description><subject>Adult</subject><subject>Age</subject><subject>Amenorrhea</subject><subject>Analysis</subject><subject>Benign</subject><subject>Biology and Life Sciences</subject><subject>Cystectomy - adverse effects</subject><subject>Cysts</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fertility</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Infertility</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Menstruation</subject><subject>Obstetrics</subject><subject>Patients</subject><subject>Postoperative Complications - epidemiology</subject><subject>Primary Ovarian Insufficiency - epidemiology</subject><subject>Primary Ovarian Insufficiency - etiology</subject><subject>Reproductive health</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Surgery</subject><subject>Surgical techniques</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12PEyEUhidG466r_8DoJCZGL1qBAWbwwqTZ-NFkk038uiWnwLQ006ELTLW_wr8sbWebjumF4QICz_seOJyTZc8xGuOixO-WrvMtNOO1a80YIVHhkj7ILrEoyIgTVDw8WV9kT0JYIsSKivPH2QWhFauEEJfZn0ny2AYbclfnDUQzcm0wMXcb8Bba3Lahq2urrGnVNoc6Gn88C52fG799n3sTvQtro6LdmDzETm_zXzYu8pLla4hJG_f-axfiaKeyCprzIZ5mj2pognnWz1fZj08fv19_Gd3cfp5eT25GigsSR7SeIc5KTCqGCCZQa6ZESUpRKK0LwqguNRdcAIZSacMBzUTFMQPOtK6RKq6ylwffdeOC7HMZJGakQiXFDCdieiC0g6Vce7sCv5UOrNxvOD-X4KNVjZFiRtiMcgqMVxQVDBAFo0VNhREaUZK8PvTRutnKaJUS4qEZmA5PWruQc7eRyY2QskwGb3oD7-46E6Jc2aBM00BrXLe_t6goJ5gm9NU_6PnX9dQc0gNsW7sUV-1M5YTiCpOSsSpR4zNUGtqsrEqFV9u0PxC8HQgSE83vOIcuBDn99vX_2dufQ_b1Cbsw0MRFcE0XbSrXIUgPoEoVGbypj0nGSO765j4bctc3su-bJHtx-kFH0X2jFH8BuEgVdQ</recordid><startdate>20140523</startdate><enddate>20140523</enddate><creator>Takae, Seido</creator><creator>Kawamura, Kazuhiro</creator><creator>Sato, Yorino</creator><creator>Nishijima, Chie</creator><creator>Yoshioka, Nobuhito</creator><creator>Sugishita, Yodo</creator><creator>Horage, Yuki</creator><creator>Tanaka, Mamoru</creator><creator>Ishizuka, Bunpei</creator><creator>Suzuki, Nao</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140523</creationdate><title>Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency</title><author>Takae, Seido ; Kawamura, Kazuhiro ; Sato, Yorino ; Nishijima, Chie ; Yoshioka, Nobuhito ; Sugishita, Yodo ; Horage, Yuki ; Tanaka, Mamoru ; Ishizuka, Bunpei ; Suzuki, Nao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4fb065712850212afd5c972793cdd3254d7d6969a1a7cde6a0b98615a65ddf0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age</topic><topic>Amenorrhea</topic><topic>Analysis</topic><topic>Benign</topic><topic>Biology and Life Sciences</topic><topic>Cystectomy - 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Data were obtained from 75 patients who underwent surgery for benign ovarian cysts prior to the onset of ovarian insufficiency. Our analysis included 835 ovarian insufficiency patients who were referred to our institution from July 2003 to July 2013. Several epidemiological parameters of ovarian insufficiency after surgery (age at operation, period of onset of ovarian insufficiency, operation procedure, and pathological diagnosis) were investigated. Of the 835 patients who had ovarian insufficiency, 75 patients (9.0%) underwent ovarian surgery before the onset of ovarian insufficiency. Of those 75 patients, 66 patients (88.0%) underwent cystectomy. For the majority of the 75 patients the surgical indication was the presence of endometriotic cysts (57 patients; 76.0%). Twelve patients (16.0%) underwent multiple surgeries (all bilateral cystectomies). The mean age of the patients at the time of surgery was 27.8±5.5 years-old, and the mean period of onset of ovarian insufficiency was 5.8±3.8 years. In patients with cystectomy, the patient's age at the time of surgery and period of onset of ovarian insufficiency was well-correlated (coefficient of correlation; hemilateral endometriotic cystectomy: -0.64, bilateral endometriotic cystectomy: -0.61, and multiple endimetriotic cystectomy: -0.40). We found that cystectomy of endometriotic cysts is the potential risk factor for ovarian insufficiency after surgery, at times, the onset of ovarian insufficiency long after cystectomy. Therefore, it is important to monitor ovarian reserve for an extended period of time after ovarian surgery. It is particularly important to monitor ovarian reserve long-term for patients who wish to conceive in the future and to suggest a variety of infertility treatments appropriate for their ovarian reserve.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24858999</pmid><doi>10.1371/journal.pone.0098174</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-05, Vol.9 (5), p.e98174-e98174 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Amenorrhea Analysis Benign Biology and Life Sciences Cystectomy - adverse effects Cysts Epidemiology Female Fertility Gynecology Humans Infertility Laparoscopy Male Medical research Medicine Medicine and Health Sciences Menstruation Obstetrics Patients Postoperative Complications - epidemiology Primary Ovarian Insufficiency - epidemiology Primary Ovarian Insufficiency - etiology Reproductive health Retrospective Studies Risk analysis Risk factors Studies Surgery Surgical techniques |
| title | Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T03%3A51%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20late-onset%20ovarian%20insufficiency%20after%20ovarian%20surgery:%20retrospective%20study%20with%2075%20patients%20of%20post-surgical%20ovarian%20insufficiency&rft.jtitle=PloS%20one&rft.au=Takae,%20Seido&rft.date=2014-05-23&rft.volume=9&rft.issue=5&rft.spage=e98174&rft.epage=e98174&rft.pages=e98174-e98174&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0098174&rft_dat=%3Cgale_plos_%3EA418127558%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1528074151&rft_id=info:pmid/24858999&rft_galeid=A418127558&rft_doaj_id=oai_doaj_org_article_9b25b464a5684035a04aed9f49e9d042&rfr_iscdi=true |