Targeting of the MYCN protein with small molecule c-MYC inhibitors

Members of the MYC family are the most frequently deregulated oncogenes in human cancer and are often correlated with aggressive disease and/or poorly differentiated tumors. Since patients with MYCN-amplified neuroblastoma have a poor prognosis, targeting MYCN using small molecule inhibitors could r...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97285-e97285
Hauptverfasser:	Müller, Inga, Larsson, Karin, Frenzel, Anna, Oliynyk, Ganna, Zirath, Hanna, Prochownik, Edward V, Westwood, Nicholas J, Henriksson, Marie Arsenian
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Amino Acid Sequence Amino acids Amplification Analogs Analysis Apoptosis Apoptosis - drug effects Axonogenesis Basic-Leucine Zipper Transcription Factors - metabolism Binding Binding sites Biology Biology and Life Sciences c-Myc protein Cancer Cancer genetics Cell cycle Cell Differentiation - drug effects Cell growth Cell Line, Tumor Cell Proliferation - drug effects Deregulation Dimerization Gene amplification Health aspects Humans Inhibition Inhibitors Lipid Metabolism - drug effects Medicine and Health Sciences Metabolites Mitochondria Molecular Sequence Data Mutation Myc protein N-Myc Proto-Oncogene Protein Neural networks Neuroblastoma Neuroblastoma - pathology Neuroblastoma cells Nuclear Proteins - chemistry Nuclear Proteins - metabolism Oncogene Proteins - chemistry Oncogene Proteins - metabolism Oxadiazoles - pharmacology Prognosis Protein Folding - drug effects Protein Structure, Tertiary Proteins Proteolysis - drug effects Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - chemistry Proto-Oncogene Proteins c-myc - metabolism Small Molecule Libraries - metabolism Small Molecule Libraries - pharmacology Surface plasmon resonance Tumors
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