β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice

Recent nutritional epidemiological surveys showed that serum β-cryptoxanthin inversely associates with the risks for insulin resistance and liver dysfunction. Consumption of β-cryptoxanthin possibly prevents nonalcoholic steatohepatitis (NASH), which is suggested to be caused by insulin resistance a...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98294
Hauptverfasser:	Kobori, Masuko, Ni, Yinhua, Takahashi, Yumiko, Watanabe, Natsumi, Sugiura, Minoru, Ogawa, Kazunori, Nagashimada, Mayumi, Kaneko, Shuichi, Naito, Shigehiro, Ota, Tsuguhito
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Animals Antigens, Differentiation - biosynthesis Biology and Life Sciences Brain research Cell activation Cell death Cholesterol Cholesterol - adverse effects Cholesterol - pharmacology Citrus unshiu Cryptoxanthins - pharmacology Cytotoxicity Diabetes Diet Dietary Fats - adverse effects Dietary Fats - pharmacology Disease control Epidemiology Ethanol Fatty liver Fibrosis Food Free radicals Gene expression Gene Expression Regulation - drug effects Genes Helper cells Hepatology High cholesterol diet High fat diet Homeostasis Immune system Infiltration Inflammation Inflammation - chemically induced Inflammation - drug therapy Insulin Insulin Resistance Laboratory animals Leukocytes Lipid metabolism Lipids Lipopolysaccharides Liver Liver diseases Lymphocytes Lymphocytes T Macrophages Macrophages - metabolism Macrophages - pathology Male Medicine and Health Sciences Metabolic syndrome Metabolism Metabolites Mice Non-alcoholic Fatty Liver Disease - chemically induced Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Nutrition research Obesity Oxidation resistance Oxidative stress Research and Analysis Methods Rodents Science Steatosis Stellate cells T-Lymphocytes - metabolism T-Lymphocytes - pathology Thiobarbituric acid Tumor necrosis factor-α University graduates Weight control
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