HCC development is associated to peripheral insulin resistance in a mouse model of NASH

NAFLD is the most common liver disease worldwide but it is the potential evolution to NASH and eventually to hepatocellular carcinoma (HCC), even in the absence of cirrhosis, that makes NAFLD of such clinical importance. we aimed to create a mouse model reproducing the pathological spectrum of NAFLD...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97136
Hauptverfasser:	De Minicis, Samuele, Agostinelli, Laura, Rychlicki, Chiara, Sorice, Gian Pio, Saccomanno, Stefania, Candelaresi, Cinzia, Giaccari, Andrea, Trozzi, Luciano, Pierantonelli, Irene, Mingarelli, Eleonora, Marzioni, Marco, Muscogiuri, Giovanna, Gaggini, Melania, Benedetti, Antonio, Gastaldelli, Amalia, Guido, Maria, Svegliati-Baroni, Gianluca
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors AKT protein Amino acids Analysis Animals Biocompatibility Biology and Life Sciences Biomedical materials c-Myc protein Carbon tetrachloride Carcinogenesis Carcinogens Carcinoma, Hepatocellular - etiology Choline Choline Deficiency Cirrhosis Diabetes Diet Disease Models, Animal Endocrinology Fibrosis Food, Formulated Gastroenterology Growth factors Heparan sulfate proteoglycans Hepatocellular carcinoma Hepatology Inflammation Insulin Insulin resistance Insulin Resistance - physiology Insulin-Like Growth Factor II - metabolism Insulin-like growth factors Liver Liver cancer Liver cirrhosis Liver diseases Liver Neoplasms - etiology Medicine and Health Sciences Metabolic disorders Metabolic syndrome Mice Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - physiopathology Nutrient deficiency Obesity Osteopontin Osteopontin - metabolism Pathogenesis Physiology Proto-Oncogene Proteins c-myc - metabolism Research and Analysis Methods Rodents Steatosis Tumors
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