A conserved motif in the linker domain of STAT1 transcription factor is required for both recognition and release from high-affinity DNA-binding sites

Binding to specific palindromic sequences termed gamma-activated sites (GAS) is a hallmark of gene activation by members of the STAT (signal transducer and activator of transcription) family of cytokine-inducible transcription factors. However, the precise molecular mechanisms involved in the signal...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97633
Hauptverfasser:	Hüntelmann, Bettina, Staab, Julia, Herrmann-Lingen, Christoph, Meyer, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Acids Activation Active Transport, Cell Nucleus - drug effects Affinity Alanine Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution Amino acids Binding Sites Biology and Life Sciences Cell Nucleus - drug effects Cell Nucleus - metabolism Chemical properties Conserved Sequence Cytokines Deoxyribonucleic acid Dimers Dissociation DNA DNA - genetics DNA - metabolism Gene expression Gene Expression Regulation - drug effects Gene sequencing Genes Glutamate Glutamic acid Glycerol HeLa Cells Humans Interferon Interferon-gamma - pharmacology Inverted Repeat Sequences Kinases Kinetics Lysine Models, Molecular Molecular modelling Mutagenesis Mutation Nucleotide sequence Phosphorylation Phosphorylation - drug effects Plasmids Protein Binding Protein Structure, Tertiary Proteins Recognition Residues RNA polymerase Signal transduction Site-directed mutagenesis Stat1 protein STAT1 Transcription Factor - chemistry STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Transcription activation Transcription factors Transcription, Genetic - drug effects Tyrosine Tyrosine - metabolism γ-Interferon
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