Genome-wide analysis of cold adaptation in indigenous Siberian populations

Following the dispersal out of Africa, where hominins evolved in warm environments for millions of years, our species has colonised different climate zones of the world, including high latitudes and cold environments. The extent to which human habitation in (sub-)Arctic regions has been enabled by c...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98076
Hauptverfasser:	Cardona, Alexia, Pagani, Luca, Antao, Tiago, Lawson, Daniel J, Eichstaedt, Christina A, Yngvadottir, Bryndis, Shwe, Ma Than Than, Wee, Joseph, Romero, Irene Gallego, Raj, Srilakshmi, Metspalu, Mait, Villems, Richard, Willerslev, Eske, Tyler-Smith, Chris, Malyarchuk, Boris A, Derenko, Miroslava V, Kivisild, Toomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization Acclimatization - genetics Adaptation Adaptations Analysis Archaeology Arctic zone Biological evolution Biology and Life Sciences Blood pressure Cancer Cardiovascular disease Cell cycle Chromosome 11 Climate Climatic extremes Clustering Cold Cold Climate Cold climates Cold pressing Dispersal Energy metabolism Evolution, Molecular Evolutionary biology Extreme cold Extreme low temperatures Gene expression Gene frequency Gene regulation Genes Genetics Genomes Genomics Haplotypes Heart rate Heat Homozygosity Humans Ice environments Kinases LRP5 protein Metabolic rate Metabolism Muscle contraction Muscles Physiological aspects Physiology Polar environments Polymorphism, Single Nucleotide Population Groups - ethnology Population Groups - genetics Populations Positive selection Selection, Genetic Siberia - ethnology Single nucleotide polymorphisms Single-nucleotide polymorphism Smooth muscle
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