Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function
Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-...
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| creator | Kraitsy, Klaus Uecal, Muammer Grossauer, Stefan Bruckmann, Lukas Pfleger, Florentina Ropele, Stefan Fazekas, Franz Gruenbacher, Gerda Patz, Silke Absenger, Markus Porubsky, Christian Smolle-Juettner, Freyja Tezer, Irem Molcanyi, Marek Fasching, Ulrike Schaefer, Ute |
| description | Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function. |
| doi_str_mv | 10.1371/journal.pone.0097750 |
| format | Article |
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Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0097750</identifier><identifier>PMID: 24848795</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Apoptosis ; Biology and Life Sciences ; Brain ; Brain - pathology ; Brain - physiopathology ; Brain damage ; Brain Injuries - pathology ; Brain Injuries - physiopathology ; Brain Injuries - therapy ; Brain research ; Central nervous system ; Cortex (somatosensory) ; Deprivation ; Evoked Potentials ; Head injuries ; Hyperbaric oxygen therapy ; Hyperbaric Oxygenation ; Hypoxia ; Injuries ; Ischemia ; Isoforms ; Male ; Medicine and Health Sciences ; Metabolism ; Multiple sclerosis ; Myelin ; Myelin basic protein ; Myelin proteins ; Myelin proteolipid protein ; Myelin Sheath - physiology ; Myelination ; Nervous system ; Neurological complications ; Neurosurgery ; Oxygen ; Patient outcomes ; Patients ; Percussion ; Physiological aspects ; Proteins ; Psychomotor Performance ; Rats ; Rats, Sprague-Dawley ; Recovery ; Recovery (Medical) ; Recovery of Function ; Regression analysis ; Research and Analysis Methods ; Rodents ; Sensorimotor system ; Somatosensory evoked potentials ; Stroke ; Surgery ; Time Factors ; Traumatic brain injury</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e97750-e97750</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Kraitsy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Kraitsy et al 2014 Kraitsy et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-141a82d22320c21d913b1f0568aa93fa38982d875ce2d7013b4ab5ce078f6f4b3</citedby><cites>FETCH-LOGICAL-c692t-141a82d22320c21d913b1f0568aa93fa38982d875ce2d7013b4ab5ce078f6f4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029808/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029808/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24848795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraitsy, Klaus</creatorcontrib><creatorcontrib>Uecal, Muammer</creatorcontrib><creatorcontrib>Grossauer, Stefan</creatorcontrib><creatorcontrib>Bruckmann, Lukas</creatorcontrib><creatorcontrib>Pfleger, Florentina</creatorcontrib><creatorcontrib>Ropele, Stefan</creatorcontrib><creatorcontrib>Fazekas, Franz</creatorcontrib><creatorcontrib>Gruenbacher, Gerda</creatorcontrib><creatorcontrib>Patz, Silke</creatorcontrib><creatorcontrib>Absenger, Markus</creatorcontrib><creatorcontrib>Porubsky, Christian</creatorcontrib><creatorcontrib>Smolle-Juettner, Freyja</creatorcontrib><creatorcontrib>Tezer, Irem</creatorcontrib><creatorcontrib>Molcanyi, Marek</creatorcontrib><creatorcontrib>Fasching, Ulrike</creatorcontrib><creatorcontrib>Schaefer, Ute</creatorcontrib><title>Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain damage</subject><subject>Brain Injuries - pathology</subject><subject>Brain Injuries - physiopathology</subject><subject>Brain Injuries - therapy</subject><subject>Brain research</subject><subject>Central nervous system</subject><subject>Cortex (somatosensory)</subject><subject>Deprivation</subject><subject>Evoked Potentials</subject><subject>Head injuries</subject><subject>Hyperbaric oxygen therapy</subject><subject>Hyperbaric 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One</addtitle><date>2014-05-21</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e97750</spage><epage>e97750</epage><pages>e97750-e97750</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24848795</pmid><doi>10.1371/journal.pone.0097750</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-05, Vol.9 (5), p.e97750-e97750 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1526930155 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Animals Apoptosis Biology and Life Sciences Brain Brain - pathology Brain - physiopathology Brain damage Brain Injuries - pathology Brain Injuries - physiopathology Brain Injuries - therapy Brain research Central nervous system Cortex (somatosensory) Deprivation Evoked Potentials Head injuries Hyperbaric oxygen therapy Hyperbaric Oxygenation Hypoxia Injuries Ischemia Isoforms Male Medicine and Health Sciences Metabolism Multiple sclerosis Myelin Myelin basic protein Myelin proteins Myelin proteolipid protein Myelin Sheath - physiology Myelination Nervous system Neurological complications Neurosurgery Oxygen Patient outcomes Patients Percussion Physiological aspects Proteins Psychomotor Performance Rats Rats, Sprague-Dawley Recovery Recovery (Medical) Recovery of Function Regression analysis Research and Analysis Methods Rodents Sensorimotor system Somatosensory evoked potentials Stroke Surgery Time Factors Traumatic brain injury |
| title | Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T23%3A39%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Repetitive%20long-term%20hyperbaric%20oxygen%20treatment%20(HBOT)%20administered%20after%20experimental%20traumatic%20brain%20injury%20in%20rats%20induces%20significant%20remyelination%20and%20a%20recovery%20of%20sensorimotor%20function&rft.jtitle=PloS%20one&rft.au=Kraitsy,%20Klaus&rft.date=2014-05-21&rft.volume=9&rft.issue=5&rft.spage=e97750&rft.epage=e97750&rft.pages=e97750-e97750&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0097750&rft_dat=%3Cgale_plos_%3EA418139122%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1526930155&rft_id=info:pmid/24848795&rft_galeid=A418139122&rft_doaj_id=oai_doaj_org_article_43f23fc2642846d0ada9dc34691972a9&rfr_iscdi=true |