Designing anti-influenza aptamers: novel quantitative structure activity relationship approach gives insights into aptamer-virus interaction

This study describes the development of aptamers as a therapy against influenza virus infection. Aptamers are oligonucleotides (like ssDNA or RNA) that are capable of binding to a variety of molecular targets with high affinity and specificity. We have studied the ssDNA aptamer BV02, which was desig...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97696-e97696
Hauptverfasser:	Musafia, Boaz, Oren-Banaroya, Rony, Noiman, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Analysis Animal models Animals Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Aptamers Aptamers, Nucleotide - chemical synthesis Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - pharmacology Binding Biology and Life Sciences Cell culture Computer applications Correlation Deoxyribonucleic acid DNA Dogs Drug Design Health aspects Hemagglutinins Immunoglobulins Infections Influenza Influenza A Virus, H1N1 Subtype - metabolism Influenza A Virus, H3N2 Subtype - metabolism Lead Lectins Madin Darby Canine Kidney Cells Mathematical models Medicine and Health Sciences Model testing Mutation Nucleotides Oligonucleotides Optimization Orthomyxoviridae Infections - drug therapy Physical Sciences Physicochemical properties Polymers Properties (attributes) Ribonucleic acid RNA Software Structure-Activity Relationship Structure-activity relationships Viral infections Viruses
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