Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes
Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube defects, these effects have not been elucidated in detail. We evaluated whether folic acid supplementation is associated with favorable maternal...
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| description | Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube defects, these effects have not been elucidated in detail. We evaluated whether folic acid supplementation is associated with favorable maternal and fetal outcomes. This was a secondary analysis of 215 pregnant women who were enrolled in our prior study. With additional data from telephone interviews regarding prenatal folic acid supplementation, existing demographic, maternal and fetal data were statistically analyzed. The concentration of folic acid in maternal blood was significantly higher following folic acid supplementation (24.6 ng/mL vs.11.8 ng/mL). In contrast, homocysteine level in maternal blood decreased with folic acid supplementation (5.5 µmol/mL vs. 6.8 µmol/mL). The rates of both preeclampsia (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.09-0.76) and small for gestational age (SGA; 9.2% vs. 20.0%; OR, 0.42; 95% CI, 0.18-0.99) were lower in the folic acid supplementation group than those in the control group. Other pregnancy outcomes had no association with folic acid supplementation. The findings indicate that folic acid supplementation may help to prevent preeclampsia and SGA. Further studies are warranted to elucidate the favorable effects of folic acid supplementation on pregnancy outcomes. |
| doi_str_mv | 10.1371/journal.pone.0097273 |
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We evaluated whether folic acid supplementation is associated with favorable maternal and fetal outcomes. This was a secondary analysis of 215 pregnant women who were enrolled in our prior study. With additional data from telephone interviews regarding prenatal folic acid supplementation, existing demographic, maternal and fetal data were statistically analyzed. The concentration of folic acid in maternal blood was significantly higher following folic acid supplementation (24.6 ng/mL vs.11.8 ng/mL). In contrast, homocysteine level in maternal blood decreased with folic acid supplementation (5.5 µmol/mL vs. 6.8 µmol/mL). The rates of both preeclampsia (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.09-0.76) and small for gestational age (SGA; 9.2% vs. 20.0%; OR, 0.42; 95% CI, 0.18-0.99) were lower in the folic acid supplementation group than those in the control group. Other pregnancy outcomes had no association with folic acid supplementation. The findings indicate that folic acid supplementation may help to prevent preeclampsia and SGA. Further studies are warranted to elucidate the favorable effects of folic acid supplementation on pregnancy outcomes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0097273</identifier><identifier>PMID: 24842467</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Adult ; Age ; Analysis ; Biology and Life Sciences ; Birth weight ; Blood ; Confidence intervals ; Data processing ; Demographics ; Diabetes ; Dietary Supplements ; DNA methylation ; Female ; Fetuses ; Folic acid ; Folic Acid - blood ; Folic Acid - therapeutic use ; Gestational age ; Gestational diabetes ; Gynecology ; Health risk assessment ; Homocysteine ; Hospitals ; Humans ; Infant, Small for Gestational Age ; Logistic Models ; Medicine ; Medicine and Health Sciences ; Metabolism ; Neural tube defects ; Obstetrics ; Placenta ; Population ; Pre-eclampsia ; Pre-Eclampsia - prevention & control ; Preeclampsia ; Pregnancy ; Pregnancy Outcome ; Pregnant women ; Premature birth ; Prenatal experience ; Research and Analysis Methods ; Secondary analysis ; Small for gestational age ; Supplementation ; Supplements ; Vitamin B ; Womens health</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e97273</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Kim et al 2014 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4cbb3a9658fcabdf9ba19764d238ec7c54e5ee5808323195e9d1a6aedaa5e68f3</citedby><cites>FETCH-LOGICAL-c692t-4cbb3a9658fcabdf9ba19764d238ec7c54e5ee5808323195e9d1a6aedaa5e68f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026223/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026223/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24842467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dastgiri, Saeed</contributor><creatorcontrib>Kim, Min Woo</creatorcontrib><creatorcontrib>Ahn, Ki Hoon</creatorcontrib><creatorcontrib>Ryu, Ki-Jin</creatorcontrib><creatorcontrib>Hong, Soon-Cheol</creatorcontrib><creatorcontrib>Lee, Ji Sung</creatorcontrib><creatorcontrib>Nava-Ocampo, Alejandro A</creatorcontrib><creatorcontrib>Oh, Min-Jeong</creatorcontrib><creatorcontrib>Kim, Hai-Joong</creatorcontrib><title>Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube defects, these effects have not been elucidated in detail. We evaluated whether folic acid supplementation is associated with favorable maternal and fetal outcomes. This was a secondary analysis of 215 pregnant women who were enrolled in our prior study. With additional data from telephone interviews regarding prenatal folic acid supplementation, existing demographic, maternal and fetal data were statistically analyzed. The concentration of folic acid in maternal blood was significantly higher following folic acid supplementation (24.6 ng/mL vs.11.8 ng/mL). In contrast, homocysteine level in maternal blood decreased with folic acid supplementation (5.5 µmol/mL vs. 6.8 µmol/mL). The rates of both preeclampsia (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.09-0.76) and small for gestational age (SGA; 9.2% vs. 20.0%; OR, 0.42; 95% CI, 0.18-0.99) were lower in the folic acid supplementation group than those in the control group. Other pregnancy outcomes had no association with folic acid supplementation. The findings indicate that folic acid supplementation may help to prevent preeclampsia and SGA. Further studies are warranted to elucidate the favorable effects of folic acid supplementation on pregnancy outcomes.</description><subject>Acids</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Confidence intervals</subject><subject>Data processing</subject><subject>Demographics</subject><subject>Diabetes</subject><subject>Dietary Supplements</subject><subject>DNA methylation</subject><subject>Female</subject><subject>Fetuses</subject><subject>Folic acid</subject><subject>Folic Acid - blood</subject><subject>Folic Acid - therapeutic use</subject><subject>Gestational age</subject><subject>Gestational diabetes</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Homocysteine</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant, Small for Gestational Age</subject><subject>Logistic Models</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Neural tube defects</subject><subject>Obstetrics</subject><subject>Placenta</subject><subject>Population</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - prevention & control</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnant women</subject><subject>Premature birth</subject><subject>Prenatal experience</subject><subject>Research and Analysis Methods</subject><subject>Secondary analysis</subject><subject>Small for gestational age</subject><subject>Supplementation</subject><subject>Supplements</subject><subject>Vitamin B</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6D0QLguDFjE3StMmNsCx-DCys-HkZTpOTmQxtMzbpoP_ejNNdpqAgCSQkz3lzePNm2VNSLAmryeutH4ce2uXO97gsClnTmt3LzolkdFHRgt0_2Z9lj0LYFgVnoqoeZme0FCUtq_o8-_5xwD320e0xR2tRx5B7m1vfOp2DdiYP427XYpcYiM73eZpg9jgEzDuIeOghh97kFmPa-TFq32F4nD2w0AZ8Mq0X2dd3b79cfVhc37xfXV1eL3QlaVyUumkYyIoLq6ExVjZAZF2VhjKButa8RI7IRSEYZURylIZABWgAOFbCsovs-VF31_qgJk-CIpxyyXkSTsTqSBgPW7UbXAfDL-XBqT8HflgrGKLTLSoJghNLjdBClsY2wqCsQJZIqcZC6qT1ZnptbDo0OpkyQDsTnd_0bqPWfq_KglaUsiTwYhIY_I8RQ_xHyxO1htSV661PYrpzQavLkgjCRPrTRC3_QqVhsHM6pcK6dD4reDUrSEzEn3ENYwhq9fnT_7M33-bsyxN2g9DGTfDteIhLmIPlEdSDD2FAe-ccKdQh1LduqEOo1RTqVPbs1PW7otsUs997NPOr</recordid><startdate>20140519</startdate><enddate>20140519</enddate><creator>Kim, Min Woo</creator><creator>Ahn, Ki Hoon</creator><creator>Ryu, Ki-Jin</creator><creator>Hong, Soon-Cheol</creator><creator>Lee, Ji Sung</creator><creator>Nava-Ocampo, Alejandro A</creator><creator>Oh, Min-Jeong</creator><creator>Kim, Hai-Joong</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140519</creationdate><title>Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes</title><author>Kim, Min Woo ; Ahn, Ki Hoon ; Ryu, Ki-Jin ; Hong, Soon-Cheol ; Lee, Ji Sung ; Nava-Ocampo, Alejandro A ; Oh, Min-Jeong ; Kim, Hai-Joong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4cbb3a9658fcabdf9ba19764d238ec7c54e5ee5808323195e9d1a6aedaa5e68f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Age</topic><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Birth weight</topic><topic>Blood</topic><topic>Confidence intervals</topic><topic>Data processing</topic><topic>Demographics</topic><topic>Diabetes</topic><topic>Dietary Supplements</topic><topic>DNA methylation</topic><topic>Female</topic><topic>Fetuses</topic><topic>Folic acid</topic><topic>Folic Acid - blood</topic><topic>Folic Acid - therapeutic use</topic><topic>Gestational age</topic><topic>Gestational diabetes</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Homocysteine</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant, Small for Gestational Age</topic><topic>Logistic Models</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Neural tube defects</topic><topic>Obstetrics</topic><topic>Placenta</topic><topic>Population</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - prevention & control</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnant women</topic><topic>Premature birth</topic><topic>Prenatal experience</topic><topic>Research and Analysis Methods</topic><topic>Secondary analysis</topic><topic>Small for gestational age</topic><topic>Supplementation</topic><topic>Supplements</topic><topic>Vitamin B</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Min Woo</creatorcontrib><creatorcontrib>Ahn, Ki Hoon</creatorcontrib><creatorcontrib>Ryu, Ki-Jin</creatorcontrib><creatorcontrib>Hong, Soon-Cheol</creatorcontrib><creatorcontrib>Lee, Ji Sung</creatorcontrib><creatorcontrib>Nava-Ocampo, Alejandro A</creatorcontrib><creatorcontrib>Oh, Min-Jeong</creatorcontrib><creatorcontrib>Kim, Hai-Joong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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We evaluated whether folic acid supplementation is associated with favorable maternal and fetal outcomes. This was a secondary analysis of 215 pregnant women who were enrolled in our prior study. With additional data from telephone interviews regarding prenatal folic acid supplementation, existing demographic, maternal and fetal data were statistically analyzed. The concentration of folic acid in maternal blood was significantly higher following folic acid supplementation (24.6 ng/mL vs.11.8 ng/mL). In contrast, homocysteine level in maternal blood decreased with folic acid supplementation (5.5 µmol/mL vs. 6.8 µmol/mL). The rates of both preeclampsia (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.09-0.76) and small for gestational age (SGA; 9.2% vs. 20.0%; OR, 0.42; 95% CI, 0.18-0.99) were lower in the folic acid supplementation group than those in the control group. Other pregnancy outcomes had no association with folic acid supplementation. The findings indicate that folic acid supplementation may help to prevent preeclampsia and SGA. Further studies are warranted to elucidate the favorable effects of folic acid supplementation on pregnancy outcomes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24842467</pmid><doi>10.1371/journal.pone.0097273</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Adult Age Analysis Biology and Life Sciences Birth weight Blood Confidence intervals Data processing Demographics Diabetes Dietary Supplements DNA methylation Female Fetuses Folic acid Folic Acid - blood Folic Acid - therapeutic use Gestational age Gestational diabetes Gynecology Health risk assessment Homocysteine Hospitals Humans Infant, Small for Gestational Age Logistic Models Medicine Medicine and Health Sciences Metabolism Neural tube defects Obstetrics Placenta Population Pre-eclampsia Pre-Eclampsia - prevention & control Preeclampsia Pregnancy Pregnancy Outcome Pregnant women Premature birth Prenatal experience Research and Analysis Methods Secondary analysis Small for gestational age Supplementation Supplements Vitamin B Womens health |
| title | Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes |
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