The association between atrium electromechanical interval and pericardial fat
Pericardial fat (PCF) may induce local inflammation and subsequent structural remodeling of the left atrium (LA). However, the adverse effects of PCF on LA are difficult to be evaluated and quantified. The atrial electromechanical interval determined by transthoracic echocardiogram was shown to be a...
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| creator | Chao, Tze-Fan Lai, Yau-Huei Yun, Chun-Ho Yen, Chih-Hsuan Wang, Kang-Ling Lin, Yenn-Jiang Chang, Shih-Lin Lo, Li-Wei Hu, Yu-Feng Hung, Chung-Lieh Kuo, Jen-Yuan Yeh, Hung-I Chen, Shih-Ann |
| description | Pericardial fat (PCF) may induce local inflammation and subsequent structural remodeling of the left atrium (LA). However, the adverse effects of PCF on LA are difficult to be evaluated and quantified. The atrial electromechanical interval determined by transthoracic echocardiogram was shown to be a convenient parameter which can reflect the process of LA remodeling. The goal of the present study was to investigate the association between the electromechanical interval and PCF.
A total of 337 patients with mean age of 51.9 ± 9.0 years were enrolled. The electromechanical interval (PA-PDI) defined as the time interval from the initiation of the P wave deflection to the peak of the mitral inflow A wave on the pulse wave Doppler imaging was measured for every patient. The amount of PCF was determined by multi-detector computed tomography. The PA-PDI interval was significantly correlated with the amount of PCF (r = 0.641, p value |
| doi_str_mv | 10.1371/journal.pone.0097472 |
| format | Article |
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A total of 337 patients with mean age of 51.9 ± 9.0 years were enrolled. The electromechanical interval (PA-PDI) defined as the time interval from the initiation of the P wave deflection to the peak of the mitral inflow A wave on the pulse wave Doppler imaging was measured for every patient. The amount of PCF was determined by multi-detector computed tomography. The PA-PDI interval was significantly correlated with the amount of PCF (r = 0.641, p value <0.001). Graded prolongation of PA-PDI interval was observed across 3 groups of patients divided according to the tertile values of PCF. The AUC for the PA-PDI interval in predicting an increased amount of PCF (third tertile) was 0.796. At a cutoff value of 130 ms identified by the ROC curve, the sensitivity and specificity of PA-PDI interval in identifying patients with a highest tertile of PCF were 63.4% and 85.3%, respectively.
The PA-PDI intervals were longer in patients with an increased amount of PCF. It may be a useful parameter to represent the degree of PCF-related atrial remodeling.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0097472</identifier><identifier>PMID: 24841847</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Atherosclerosis ; Atrial Fibrillation - physiopathology ; Atrium ; Biology and Life Sciences ; Blood tests ; Cardiac arrhythmia ; Cardiology ; Cardiovascular disease ; Catheters ; Clinical medicine ; Computed tomography ; Doppler effect ; Echocardiography ; Echocardiography, Doppler ; Female ; Heart ; Heart Atria - physiopathology ; Heart Rate - physiology ; Hospitals ; Humans ; Inflow ; Internal medicine ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Nursing ; Parameters ; Patients ; Pericardium - metabolism ; Prolongation ; ROC Curve</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e97472-e97472</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Chao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Chao et al 2014 Chao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8cd1c5349ab0615006d7d8bb10ba1b3fcab264c6465bd9ebe754de1331c0dada3</citedby><cites>FETCH-LOGICAL-c692t-8cd1c5349ab0615006d7d8bb10ba1b3fcab264c6465bd9ebe754de1331c0dada3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026321/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026321/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79472,79473</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24841847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Calvert, John</contributor><creatorcontrib>Chao, Tze-Fan</creatorcontrib><creatorcontrib>Lai, Yau-Huei</creatorcontrib><creatorcontrib>Yun, Chun-Ho</creatorcontrib><creatorcontrib>Yen, Chih-Hsuan</creatorcontrib><creatorcontrib>Wang, Kang-Ling</creatorcontrib><creatorcontrib>Lin, Yenn-Jiang</creatorcontrib><creatorcontrib>Chang, Shih-Lin</creatorcontrib><creatorcontrib>Lo, Li-Wei</creatorcontrib><creatorcontrib>Hu, Yu-Feng</creatorcontrib><creatorcontrib>Hung, Chung-Lieh</creatorcontrib><creatorcontrib>Kuo, Jen-Yuan</creatorcontrib><creatorcontrib>Yeh, Hung-I</creatorcontrib><creatorcontrib>Chen, Shih-Ann</creatorcontrib><title>The association between atrium electromechanical interval and pericardial fat</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Pericardial fat (PCF) may induce local inflammation and subsequent structural remodeling of the left atrium (LA). However, the adverse effects of PCF on LA are difficult to be evaluated and quantified. The atrial electromechanical interval determined by transthoracic echocardiogram was shown to be a convenient parameter which can reflect the process of LA remodeling. The goal of the present study was to investigate the association between the electromechanical interval and PCF.
A total of 337 patients with mean age of 51.9 ± 9.0 years were enrolled. The electromechanical interval (PA-PDI) defined as the time interval from the initiation of the P wave deflection to the peak of the mitral inflow A wave on the pulse wave Doppler imaging was measured for every patient. The amount of PCF was determined by multi-detector computed tomography. The PA-PDI interval was significantly correlated with the amount of PCF (r = 0.641, p value <0.001). Graded prolongation of PA-PDI interval was observed across 3 groups of patients divided according to the tertile values of PCF. The AUC for the PA-PDI interval in predicting an increased amount of PCF (third tertile) was 0.796. At a cutoff value of 130 ms identified by the ROC curve, the sensitivity and specificity of PA-PDI interval in identifying patients with a highest tertile of PCF were 63.4% and 85.3%, respectively.
The PA-PDI intervals were longer in patients with an increased amount of PCF. It may be a useful parameter to represent the degree of PCF-related atrial remodeling.</description><subject>Atherosclerosis</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrium</subject><subject>Biology and Life Sciences</subject><subject>Blood tests</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Catheters</subject><subject>Clinical medicine</subject><subject>Computed tomography</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Atria - physiopathology</subject><subject>Heart Rate - physiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Inflow</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nursing</subject><subject>Parameters</subject><subject>Patients</subject><subject>Pericardium - metabolism</subject><subject>Prolongation</subject><subject>ROC Curve</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwDxBEQkJw2MWOP5JckKqKj5WKKkHhak3sya6rJF5sp8C_x9tNqw3qAflge_zMO_b4zbLnlCwpK-m7Kzf6Abrl1g24JKQueVk8yI5pzYqFLAh7eLA-yp6EcEWIYJWUj7OjglecVrw8zr5cbjCHEJy2EK0b8gbjL8Qhh-jt2OfYoY7e9ag3MFgNXW6HiP46LWAw-RZ9Cnpj076F-DR71EIX8Nk0n2TfP364PPu8OL_4tDo7PV9oWRdxUWlDtWC8hoZIKgiRpjRV01DSAG1Yq6EpJNeSS9GYGhssBTdIGaOaGDDATrKXe91t54KaOhEUFYWohah5mYjVnjAOrtTW2x78H-XAqpuA82sFPlrdoSJGCNqKwnAJXPMGTCvblhNhjC5FVSet91O1senRaByih24mOj8Z7Eat3bXipJCsoEngzSTg3c8RQ1S9DRq7DgZ04829Zclo6k1CX_2D3v-6iVpDeoAdWpfq6p2oOk0fS1lVyF3Z5T1UGgZ7q5NtWpvis4S3s4TERPwd1zCGoFbfvv4_e_Fjzr4-YDcIXdwE1407w4U5yPeg9i4Ej-1dkylRO9ffdkPtXK8m16e0F4cfdJd0a3P2Fy6j_ZY</recordid><startdate>20140519</startdate><enddate>20140519</enddate><creator>Chao, Tze-Fan</creator><creator>Lai, Yau-Huei</creator><creator>Yun, Chun-Ho</creator><creator>Yen, Chih-Hsuan</creator><creator>Wang, Kang-Ling</creator><creator>Lin, Yenn-Jiang</creator><creator>Chang, Shih-Lin</creator><creator>Lo, Li-Wei</creator><creator>Hu, Yu-Feng</creator><creator>Hung, Chung-Lieh</creator><creator>Kuo, Jen-Yuan</creator><creator>Yeh, Hung-I</creator><creator>Chen, Shih-Ann</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140519</creationdate><title>The association between atrium electromechanical interval and pericardial fat</title><author>Chao, Tze-Fan ; Lai, Yau-Huei ; Yun, Chun-Ho ; Yen, Chih-Hsuan ; Wang, Kang-Ling ; Lin, Yenn-Jiang ; Chang, Shih-Lin ; Lo, Li-Wei ; Hu, Yu-Feng ; Hung, Chung-Lieh ; Kuo, Jen-Yuan ; Yeh, Hung-I ; Chen, Shih-Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8cd1c5349ab0615006d7d8bb10ba1b3fcab264c6465bd9ebe754de1331c0dada3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Atherosclerosis</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrium</topic><topic>Biology and Life Sciences</topic><topic>Blood tests</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Catheters</topic><topic>Clinical medicine</topic><topic>Computed tomography</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Atria - physiopathology</topic><topic>Heart Rate - physiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Inflow</topic><topic>Internal medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nursing</topic><topic>Parameters</topic><topic>Patients</topic><topic>Pericardium - metabolism</topic><topic>Prolongation</topic><topic>ROC Curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chao, Tze-Fan</creatorcontrib><creatorcontrib>Lai, Yau-Huei</creatorcontrib><creatorcontrib>Yun, Chun-Ho</creatorcontrib><creatorcontrib>Yen, Chih-Hsuan</creatorcontrib><creatorcontrib>Wang, Kang-Ling</creatorcontrib><creatorcontrib>Lin, Yenn-Jiang</creatorcontrib><creatorcontrib>Chang, Shih-Lin</creatorcontrib><creatorcontrib>Lo, Li-Wei</creatorcontrib><creatorcontrib>Hu, Yu-Feng</creatorcontrib><creatorcontrib>Hung, Chung-Lieh</creatorcontrib><creatorcontrib>Kuo, Jen-Yuan</creatorcontrib><creatorcontrib>Yeh, Hung-I</creatorcontrib><creatorcontrib>Chen, Shih-Ann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chao, Tze-Fan</au><au>Lai, Yau-Huei</au><au>Yun, Chun-Ho</au><au>Yen, Chih-Hsuan</au><au>Wang, Kang-Ling</au><au>Lin, Yenn-Jiang</au><au>Chang, Shih-Lin</au><au>Lo, Li-Wei</au><au>Hu, Yu-Feng</au><au>Hung, Chung-Lieh</au><au>Kuo, Jen-Yuan</au><au>Yeh, Hung-I</au><au>Chen, Shih-Ann</au><au>Calvert, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between atrium electromechanical interval and pericardial fat</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-05-19</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e97472</spage><epage>e97472</epage><pages>e97472-e97472</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Pericardial fat (PCF) may induce local inflammation and subsequent structural remodeling of the left atrium (LA). However, the adverse effects of PCF on LA are difficult to be evaluated and quantified. The atrial electromechanical interval determined by transthoracic echocardiogram was shown to be a convenient parameter which can reflect the process of LA remodeling. The goal of the present study was to investigate the association between the electromechanical interval and PCF.
A total of 337 patients with mean age of 51.9 ± 9.0 years were enrolled. The electromechanical interval (PA-PDI) defined as the time interval from the initiation of the P wave deflection to the peak of the mitral inflow A wave on the pulse wave Doppler imaging was measured for every patient. The amount of PCF was determined by multi-detector computed tomography. The PA-PDI interval was significantly correlated with the amount of PCF (r = 0.641, p value <0.001). Graded prolongation of PA-PDI interval was observed across 3 groups of patients divided according to the tertile values of PCF. The AUC for the PA-PDI interval in predicting an increased amount of PCF (third tertile) was 0.796. At a cutoff value of 130 ms identified by the ROC curve, the sensitivity and specificity of PA-PDI interval in identifying patients with a highest tertile of PCF were 63.4% and 85.3%, respectively.
The PA-PDI intervals were longer in patients with an increased amount of PCF. It may be a useful parameter to represent the degree of PCF-related atrial remodeling.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24841847</pmid><doi>10.1371/journal.pone.0097472</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-05, Vol.9 (5), p.e97472-e97472 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Atherosclerosis Atrial Fibrillation - physiopathology Atrium Biology and Life Sciences Blood tests Cardiac arrhythmia Cardiology Cardiovascular disease Catheters Clinical medicine Computed tomography Doppler effect Echocardiography Echocardiography, Doppler Female Heart Heart Atria - physiopathology Heart Rate - physiology Hospitals Humans Inflow Internal medicine Male Medicine Medicine and Health Sciences Middle Aged Nursing Parameters Patients Pericardium - metabolism Prolongation ROC Curve |
| title | The association between atrium electromechanical interval and pericardial fat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T00%3A05%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20between%20atrium%20electromechanical%20interval%20and%20pericardial%20fat&rft.jtitle=PloS%20one&rft.au=Chao,%20Tze-Fan&rft.date=2014-05-19&rft.volume=9&rft.issue=5&rft.spage=e97472&rft.epage=e97472&rft.pages=e97472-e97472&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0097472&rft_dat=%3Cgale_plos_%3EA418138261%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1525955947&rft_id=info:pmid/24841847&rft_galeid=A418138261&rft_doaj_id=oai_doaj_org_article_0d551f52d46a4c4badf6ff405ddc7589&rfr_iscdi=true |