Proteomic analysis of Trypanosoma cruzi response to ionizing radiation stress

Trypanosoma cruzi, the causative agent of Chagas disease, is extremely resistant to ionizing radiation, enduring up to 1.5 kGy of gamma rays. Ionizing radiation can damage the DNA molecule both directly, resulting in double-strand breaks, and indirectly, as a consequence of reactive oxygen species p...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97526-e97526
Hauptverfasser:	Vieira, Helaine Graziele Santos, Grynberg, Priscila, Bitar, Mainá, Pires, Simone da Fonseca, Hilário, Heron Oliveira, Macedo, Andrea Mara, Machado, Carlos Renato, de Andrade, Hélida Monteiro, Franco, Glória Regina
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antioxidants Biology and life sciences Chagas disease Chemotherapy Dehydrogenases Deinococcus radiodurans Deoxyribonucleic acid DNA DNA damage DNA repair Drug dosages Electrophoresis, Gel, Two-Dimensional Gamma radiation Gamma rays Gel electrophoresis Gene expression Genomes Genomics Ionizing radiation Irradiated Irradiation Isoforms Mass spectrometry Mass spectroscopy Medicine and Health Sciences Molecular biology Oxidative stress Oxygen Parasites Polypeptides Post-translation Proteins Proteomics Protozoa Protozoan Proteins - analysis Radiation Radiation damage Radiation tolerance Radiation, Ionizing Reactive oxygen species Scientific imaging Stresses Tropical diseases Trypanosoma cruzi Trypanosoma cruzi - metabolism Trypanosoma cruzi - radiation effects Vector-borne diseases γ Radiation
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