A central role for GRB10 in regulation of islet function in man

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mo...

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Veröffentlicht in:	PLoS genetics 2014-04, Vol.10 (4), p.e1004235-e1004235
Hauptverfasser:	Prokopenko, Inga, Poon, Wenny, Mägi, Reedik, Prasad B, Rashmi, Salehi, S Albert, Almgren, Peter, Osmark, Peter, Bouatia-Naji, Nabila, Wierup, Nils, Fall, Tove, Stančáková, Alena, Barker, Adam, Lagou, Vasiliki, Osmond, Clive, Xie, Weijia, Lahti, Jari, Jackson, Anne U, Cheng, Yu-Ching, Liu, Jie, O'Connell, Jeffrey R, Blomstedt, Paul A, Fadista, Joao, Alkayyali, Sami, Dayeh, Tasnim, Ahlqvist, Emma, Taneera, Jalal, Lecoeur, Cecile, Kumar, Ashish, Hansson, Ola, Hansson, Karin, Voight, Benjamin F, Kang, Hyun Min, Levy-Marchal, Claire, Vatin, Vincent, Palotie, Aarno, Syvänen, Ann-Christine, Mari, Andrea, Weedon, Michael N, Loos, Ruth J F, Ong, Ken K, Nilsson, Peter, Isomaa, Bo, Tuomi, Tiinamaija, Wareham, Nicholas J, Stumvoll, Michael, Widen, Elisabeth, Lakka, Timo A, Langenberg, Claudia, Tönjes, Anke, Rauramaa, Rainer, Kuusisto, Johanna, Frayling, Timothy M, Froguel, Philippe, Walker, Mark, Eriksson, Johan G, Ling, Charlotte, Kovacs, Peter, Ingelsson, Erik, McCarthy, Mark I, Shuldiner, Alan R, Silver, Kristi D, Laakso, Markku, Groop, Leif, Lyssenko, Valeriya
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biology and life sciences Clinical Medicine Diabetes Mellitus, Type 2 Endocrinology and Diabetes Endokrinologi och diabetes Fasting - metabolism Gene loci Genetic regulation Genetic research Genome-Wide Association Study - methods Glucose Glucose - genetics Glucose - metabolism GRB10 Adaptor Protein - genetics GRB10 Adaptor Protein - metabolism Growth factors Humans Insulin Insulin - genetics Insulin - metabolism Insulin Resistance - genetics Islets of Langerhans - metabolism Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicine and Health Sciences Middle Aged Pancreas Physiological aspects Polymorphism, Single Nucleotide - genetics Receptor, Insulin - genetics Receptor, Insulin - metabolism Rodents Signal Transduction - genetics
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