Discovery of a "white-gray-opaque" tristable phenotypic switching system in candida albicans: roles of non-genetic diversity in host adaptation

Non-genetic phenotypic variations play a critical role in the adaption to environmental changes in microbial organisms. Candida albicans, a major human fungal pathogen, can switch between several morphological phenotypes. This ability is critical for its commensal lifestyle and for its ability to ca...

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Veröffentlicht in:	PLoS biology 2014-04, Vol.12 (4), p.e1001830-e1001830
Hauptverfasser:	Tao, Li, Du, Han, Guan, Guobo, Dai, Yu, Nobile, Clarissa J, Liang, Weihong, Cao, Chengjun, Zhang, Qiuyu, Zhong, Jin, Huang, Guanghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Adaptation, Physiological - physiology Animals Aspartic Acid Proteases - biosynthesis Aspartic Acid Proteases - genetics Biological diversity Biology and Life Sciences Candida albicans Candida albicans - genetics Candida albicans - pathogenicity Candida albicans - physiology Candidiasis - pathology Carbon Dioxide - metabolism Colonies & territories DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fungal Proteins - genetics Fungal Proteins - metabolism Gene expression Gene Expression Regulation, Fungal Genes, Mating Type, Fungal Genetic aspects Genetic diversity Genetic research Genetic Variation Genotype & phenotype Grants Host-Pathogen Interactions Infections Medicine and Health Sciences Mice Microbiological research Phenotype Scanning electron microscopy Transcription Factors - genetics Transcription Factors - metabolism
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