Chemical, target, and bioactive properties of allosteric modulation

Allosteric modulators are ligands for proteins that exert their effects via a different binding site than the natural (orthosteric) ligand site and hence form a conceptually distinct class of ligands for a target of interest. Here, the physicochemical and structural features of a large set of allost...

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Veröffentlicht in:	PLoS computational biology 2014-04, Vol.10 (4), p.e1003559-e1003559
Hauptverfasser:	van Westen, Gerard J P, Gaulton, Anna, Overington, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Binding sites Biology and Life Sciences Competition Computer and Information Sciences Databases, Chemical Drug dosages Kinases Ligands Models, Chemical Molecular Weight Pharmaceutical sciences Phosphotransferases Physical Sciences Physiological aspects Proteases Protein research Protein-protein interactions Proteins
Online-Zugang:	Volltext
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