Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's thyroiditis subjects from Sardinia: a common target with type 1 diabetes?
Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection has been previously linked to Type 1 diabetes (T1D) and Multiple Sclerosis. An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate...
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| description | Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection has been previously linked to Type 1 diabetes (T1D) and Multiple Sclerosis. An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate the robustness of the latter association, testing a large cohort of HT and healthy control (HCs) subjects, all from Sardinia. Prevalence of anti-MAP3865c Abs was assessed by indirect enzyme-linked immunosorbent assay (ELISA). Moreover, given that human ZnT8 is specifically expressed in the pancreatic β-cells, in the follicle epithelial cells and in the parafollicular cells of the thyroid gland, we also tested ZnT8 epitopes homologues to the MAP3865c immunodominant peptides previously identified. Indeed, Abs targeting MAP3865c and ZnT8 homologous regions display similar frequencies in patients and controls, thus suggesting that Abs recognizing these epitopes could be cross-reactive. A statistically significant difference was found between HT patients and HCs when analyzing the humoral response mounted against MAP3865c/ZnT8 homologues epitopes. To our knowledge, this is the first report, which provides statistically significant evidence sustaining the existence of an association between MAP sero-reactivity and HT. Further studies are required to investigate the relevance of MAP to HT, aimed at deciphering if this pathogen can be at play in triggering this autoimmune disease. Likewise, genetic polymorphism of the host, and other environmental factors need to be investigated. |
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An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate the robustness of the latter association, testing a large cohort of HT and healthy control (HCs) subjects, all from Sardinia. Prevalence of anti-MAP3865c Abs was assessed by indirect enzyme-linked immunosorbent assay (ELISA). Moreover, given that human ZnT8 is specifically expressed in the pancreatic β-cells, in the follicle epithelial cells and in the parafollicular cells of the thyroid gland, we also tested ZnT8 epitopes homologues to the MAP3865c immunodominant peptides previously identified. Indeed, Abs targeting MAP3865c and ZnT8 homologous regions display similar frequencies in patients and controls, thus suggesting that Abs recognizing these epitopes could be cross-reactive. A statistically significant difference was found between HT patients and HCs when analyzing the humoral response mounted against MAP3865c/ZnT8 homologues epitopes. To our knowledge, this is the first report, which provides statistically significant evidence sustaining the existence of an association between MAP sero-reactivity and HT. Further studies are required to investigate the relevance of MAP to HT, aimed at deciphering if this pathogen can be at play in triggering this autoimmune disease. Likewise, genetic polymorphism of the host, and other environmental factors need to be investigated.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0097621</identifier><identifier>PMID: 24830306</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Antibodies, Monoclonal - immunology ; Antigenic determinants ; Antigens, Bacterial - immunology ; Area Under Curve ; Asymptomatic infection ; Bacterial Proteins - immunology ; Biology and Life Sciences ; C cells ; Case-Control Studies ; Cation Transport Proteins - immunology ; Cattle ; Cohort Studies ; Crohn's disease ; Crohns disease ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - ethnology ; Diabetes Mellitus, Type 1 - immunology ; Diet therapy ; Endocrinology ; Environmental factors ; Enzyme-Linked Immunosorbent Assay ; Enzymes ; Epithelial cells ; Epithelial Cells - cytology ; Epitopes ; Epitopes - immunology ; Female ; Gene expression ; Gene polymorphism ; Genetic polymorphisms ; Hashimoto Disease - ethnology ; Hashimoto Disease - immunology ; Hashimoto's thyroiditis ; Homology ; Humans ; Immune response (humoral) ; Immunity, Humoral ; Immunoglobulin G - immunology ; Immunoglobulins ; Infection ; Infections ; Insulin-Secreting Cells - cytology ; Italy ; Male ; Medicine and Health Sciences ; Middle Aged ; Multiple sclerosis ; Mycobacterium avium ; Pancreas ; Pancreatic beta cells ; Paratuberculosis ; Patients ; Peptides ; Polymorphism ; Polymorphism, Genetic ; Research and Analysis Methods ; Somatotropin ; Statistical analysis ; Statistical significance ; Studies ; Thyroid ; Thyroid gland ; Thyroiditis ; Type 1 diabetes ; Values ; Zinc ; Zinc transporter ; Zinc Transporter 8</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e97621</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Masala et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Masala et al 2014 Masala et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a69fe1187af9963812c0a8ab6ceac34a912a2ab53800f9851187e4edb78e7e7c3</citedby><cites>FETCH-LOGICAL-c692t-a69fe1187af9963812c0a8ab6ceac34a912a2ab53800f9851187e4edb78e7e7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022723/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022723/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23853,27911,27912,53778,53780,79357,79358</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24830306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dotta, Francesco</contributor><creatorcontrib>Masala, Speranza</creatorcontrib><creatorcontrib>Cossu, Davide</creatorcontrib><creatorcontrib>Palermo, Mario</creatorcontrib><creatorcontrib>Sechi, Leonardo Antonio</creatorcontrib><title>Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's thyroiditis subjects from Sardinia: a common target with type 1 diabetes?</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection has been previously linked to Type 1 diabetes (T1D) and Multiple Sclerosis. An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate the robustness of the latter association, testing a large cohort of HT and healthy control (HCs) subjects, all from Sardinia. Prevalence of anti-MAP3865c Abs was assessed by indirect enzyme-linked immunosorbent assay (ELISA). Moreover, given that human ZnT8 is specifically expressed in the pancreatic β-cells, in the follicle epithelial cells and in the parafollicular cells of the thyroid gland, we also tested ZnT8 epitopes homologues to the MAP3865c immunodominant peptides previously identified. Indeed, Abs targeting MAP3865c and ZnT8 homologous regions display similar frequencies in patients and controls, thus suggesting that Abs recognizing these epitopes could be cross-reactive. A statistically significant difference was found between HT patients and HCs when analyzing the humoral response mounted against MAP3865c/ZnT8 homologues epitopes. To our knowledge, this is the first report, which provides statistically significant evidence sustaining the existence of an association between MAP sero-reactivity and HT. Further studies are required to investigate the relevance of MAP to HT, aimed at deciphering if this pathogen can be at play in triggering this autoimmune disease. Likewise, genetic polymorphism of the host, and other environmental factors need to be investigated.</description><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigenic determinants</subject><subject>Antigens, Bacterial - immunology</subject><subject>Area Under Curve</subject><subject>Asymptomatic infection</subject><subject>Bacterial Proteins - immunology</subject><subject>Biology and Life Sciences</subject><subject>C cells</subject><subject>Case-Control Studies</subject><subject>Cation Transport Proteins - immunology</subject><subject>Cattle</subject><subject>Cohort Studies</subject><subject>Crohn's disease</subject><subject>Crohns disease</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - ethnology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diet therapy</subject><subject>Endocrinology</subject><subject>Environmental factors</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Enzymes</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - cytology</subject><subject>Epitopes</subject><subject>Epitopes - immunology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene polymorphism</subject><subject>Genetic polymorphisms</subject><subject>Hashimoto Disease - ethnology</subject><subject>Hashimoto Disease - immunology</subject><subject>Hashimoto's thyroiditis</subject><subject>Homology</subject><subject>Humans</subject><subject>Immune response (humoral)</subject><subject>Immunity, Humoral</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins</subject><subject>Infection</subject><subject>Infections</subject><subject>Insulin-Secreting Cells - cytology</subject><subject>Italy</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Mycobacterium avium</subject><subject>Pancreas</subject><subject>Pancreatic beta cells</subject><subject>Paratuberculosis</subject><subject>Patients</subject><subject>Peptides</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Research and Analysis Methods</subject><subject>Somatotropin</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><subject>Studies</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroiditis</subject><subject>Type 1 diabetes</subject><subject>Values</subject><subject>Zinc</subject><subject>Zinc transporter</subject><subject>Zinc Transporter 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Antonio</au><au>Dotta, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's thyroiditis subjects from Sardinia: a common target with type 1 diabetes?</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-05-15</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e97621</spage><pages>e97621-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection has been previously linked to Type 1 diabetes (T1D) and Multiple Sclerosis. An association between MAP infection and Hashimoto's thyroiditis (HT) was also proposed only in a case report. This study aimed to investigate the robustness of the latter association, testing a large cohort of HT and healthy control (HCs) subjects, all from Sardinia. Prevalence of anti-MAP3865c Abs was assessed by indirect enzyme-linked immunosorbent assay (ELISA). Moreover, given that human ZnT8 is specifically expressed in the pancreatic β-cells, in the follicle epithelial cells and in the parafollicular cells of the thyroid gland, we also tested ZnT8 epitopes homologues to the MAP3865c immunodominant peptides previously identified. Indeed, Abs targeting MAP3865c and ZnT8 homologous regions display similar frequencies in patients and controls, thus suggesting that Abs recognizing these epitopes could be cross-reactive. A statistically significant difference was found between HT patients and HCs when analyzing the humoral response mounted against MAP3865c/ZnT8 homologues epitopes. To our knowledge, this is the first report, which provides statistically significant evidence sustaining the existence of an association between MAP sero-reactivity and HT. Further studies are required to investigate the relevance of MAP to HT, aimed at deciphering if this pathogen can be at play in triggering this autoimmune disease. Likewise, genetic polymorphism of the host, and other environmental factors need to be investigated.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24830306</pmid><doi>10.1371/journal.pone.0097621</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1524876213 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Antibodies, Monoclonal - immunology Antigenic determinants Antigens, Bacterial - immunology Area Under Curve Asymptomatic infection Bacterial Proteins - immunology Biology and Life Sciences C cells Case-Control Studies Cation Transport Proteins - immunology Cattle Cohort Studies Crohn's disease Crohns disease Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - ethnology Diabetes Mellitus, Type 1 - immunology Diet therapy Endocrinology Environmental factors Enzyme-Linked Immunosorbent Assay Enzymes Epithelial cells Epithelial Cells - cytology Epitopes Epitopes - immunology Female Gene expression Gene polymorphism Genetic polymorphisms Hashimoto Disease - ethnology Hashimoto Disease - immunology Hashimoto's thyroiditis Homology Humans Immune response (humoral) Immunity, Humoral Immunoglobulin G - immunology Immunoglobulins Infection Infections Insulin-Secreting Cells - cytology Italy Male Medicine and Health Sciences Middle Aged Multiple sclerosis Mycobacterium avium Pancreas Pancreatic beta cells Paratuberculosis Patients Peptides Polymorphism Polymorphism, Genetic Research and Analysis Methods Somatotropin Statistical analysis Statistical significance Studies Thyroid Thyroid gland Thyroiditis Type 1 diabetes Values Zinc Zinc transporter Zinc Transporter 8 |
| title | Recognition of zinc transporter 8 and MAP3865c homologous epitopes by Hashimoto's thyroiditis subjects from Sardinia: a common target with type 1 diabetes? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T11%3A56%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recognition%20of%20zinc%20transporter%208%20and%20MAP3865c%20homologous%20epitopes%20by%20Hashimoto's%20thyroiditis%20subjects%20from%20Sardinia:%20a%20common%20target%20with%20type%201%20diabetes?&rft.jtitle=PloS%20one&rft.au=Masala,%20Speranza&rft.date=2014-05-15&rft.volume=9&rft.issue=5&rft.spage=e97621&rft.pages=e97621-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0097621&rft_dat=%3Cgale_plos_%3EA418529295%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1524876213&rft_id=info:pmid/24830306&rft_galeid=A418529295&rft_doaj_id=oai_doaj_org_article_6a8b4f7bfba84957968691413987fa75&rfr_iscdi=true |