Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice

Perilipin 2 (Plin2) is a lipid droplet protein that has roles in both lipid and glucose homeostasis. An increase in Plin2 in liver is associated with the development of steatosis, glucose intolerance, and ceramide accumulation in alcoholic liver disease. We investigated the role of Plin2 on energy b...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e97118
Hauptverfasser:	Carr, Rotonya M, Peralta, Giselle, Yin, Xiaoyan, Ahima, Rexford S
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alcoholic beverages Alcoholism Analysis Animals Biology Blood glucose test Body Composition Body composition (biology) Body Weight Carbohydrates Carbon dioxide Ceramide Ceramides - metabolism Composition effects Diabetes Diet Down-Regulation Drug tolerance Energy balance Energy intake Enzymes Ethanol Ethanol - administration & dosage Fatty liver Fatty Liver - metabolism Feeding Gastroenterology Glucose Glucose intolerance Glucose Intolerance - metabolism Glucose tolerance Glucose Tolerance Test Hepatology Histology Homeostasis In vivo methods and tests Insulin resistance Intolerance Lipid Metabolism - physiology Lipids Lipogenesis Liver Liver - metabolism Liver cirrhosis Liver diseases Liver Diseases, Alcoholic - pathology Male Medicine Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - physiology Metabolism Mice Mice, Inbred C57BL Mice, Knockout Obesity Oxygen Oxygen Consumption Pathogenesis Perilipin-2 Physiological aspects Physiology Prevention Proteins Rodents Steatosis Studies Time Factors Triglycerides Triglycerides - metabolism
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